O:9:"MagpieRSS":24:{s:6:"parser";i:0;s:12:"current_item";a:0:{}s:5:"items";a:10:{i:0;a:11:{s:5:"title";s:42:"Mysteries of the aging Down syndrome brain";s:4:"link";s:76:"https://wikileaksisdemocracy.org/mysteries-of-the-aging-down-syndrome-brain/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 21 Nov 2021 02:09:28 +0000";s:8:"category";s:45:"Health And Scienceagingbrainmysteriessyndrome";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3598";s:11:"description";s:625:"Journal Reference: Carter R. Palmer, Christine S. Liu, William J. Romanow, Ming-Hsiang Lee, Jerold Chun. Altered cell and RNA isoform diversity in aging Down syndrome brains. Proceedings of the National Academy of Sciences, 2021; 118 (47): e2114326118 DOI: 10.1073/pnas.2114326118 ?A stunningly high level of molecular and cellular diversity was found affecting single brain cells, which ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6060:"
Journal Reference:
Carter R. Palmer, Christine S. Liu, William J. Romanow, Ming-Hsiang Lee, Jerold Chun. Altered cell and RNA isoform diversity in aging Down syndrome brains. Proceedings of the National Academy of Sciences, 2021; 118 (47): e2114326118 DOI: 10.1073/pnas.2114326118
?A stunningly high level of molecular and cellular diversity was found affecting single brain cells, which provides new avenues for understanding both Down syndrome and Alzheimer?s disease,? says senior author Jerold Chun, M.D., Ph.D., professor and senior vice president of Neuroscience Drug Discovery at Sanford Burnham Prebys.
An old question requires new techniques
Down syndrome, also known as trisomy 21, occurs when the body has an extra copy of human chromosome 21, resulting in three copies instead of the usual two. Occurring in about one in 700 births, it is the most common chromosomal disorder. In addition to their lifelong cognitive challenges, all people with Down syndrome are exceptionally vulnerable to neurodegeneration later in life.
?By the time they?re in their 40s, every single person with Down syndrome will experience some Alzheimer?s pathology,? Chun says. ?We asked what happens in the brain before Alzheimer?s disease takes hold.?
While some of the genes and biochemical pathways involved in the development of Alzheimer?s in people with Down syndrome have been identified, the bigger picture ? the cellular and molecular changes that are responsible for triggering these pathways ? remains a mystery.
To investigate this question, Chun and his team analyzed 29 post-mortem Down syndrome brains using a method called single-nucleus transcriptomics, which looks at the RNA molecules within single cells. Because RNA encodes for proteins, knowing the RNA sequence reveals which proteins are likely being produced. And while this technique is being used widely in many fields, it has never been used in the Down syndrome brain. In addition, the paper represents the first published use of long-read sequencing in the human brain, a more accurate and less error-prone gene sequencing method.
?Our study revealed unappreciated changes in brain cell types involving hundreds of thousands of never-before-seen RNAs that can?t be seen using standard techniques,? says Chun. ?These can now be considered toward understanding the brain.?
The Down syndrome brain is a rich molecular landscape
The team found several unique aspects of the Down syndrome brain that could help pinpoint the origin of Down syndrome cognitive challenges and Alzheimer?s. First, they found that in Down syndrome, there are more inhibitory than excitatory neurons in the brain overall, meaning that there are more neurons that block the brain?s electrical signals than those that trigger them. They also found early and sustained increases in activated microglia, a type of brain cell that is an emerging target for treating common forms of Alzheimer?s disease.
?We could see these microglial features in young brains, well before Alzheimer?s occurs,? says Chun. ?This finding identifies microglia as a prominent and early player in the Down syndrome brain.?
The team also found special signatures in thousands of RNAs called intra-exonic junctions, where protein-coding sections of genetic material join together to form new molecules. These junctions had only been previously seen in one gene, called APP, alterations of which are thought to cause Alzheimer?s.
The presence of these junctions is consistent with a phenomenon in the brain called somatic gene recombination: when DNA becomes shuffled around into new gene combinations. Somatic gene recombination has previously been proposed by the researchers to operate in Alzheimer?s disease, and these new findings bolster this hypothesis.
?It will take more studies to confirm whether these novel RNAs reflect somatic gene recombination or come from some other source,? Chun says. ?But given what we?ve found before in Alzheimer?s brains, this new Down syndrome evidence points in that direction, and we are excited to investigate it further.?
The best may be yet to come
Although the work is far from over, the research is an unprecedented step forward in looking at the neurobiology of Down syndrome across the lifespan, creating new avenues of research.
?It?s wonderful that people with Down syndrome are living longer now than at any point in history, and we hope our research ultimately contributes to their improved quality of life at all ages,? says Chun. ?We are grateful to the brain donors, as well as their families, for helping our team and other researchers continue to shape our understanding of both Down syndrome and Alzheimer?s disease.?
Additional authors on the study include Carter R. Palmer, Christine S. Liu, William J. Romanow and Ming-Hsiang Lee, all from Chun?s lab at Sanford Burnham Prebys; Palmer and Liu are also students at the University of California, San Diego Biomedical Sciences Program.
The research was supported by funding from the National Institute on Aging, the National Institute of General Medical Sciences (NIH grants R56AG073965, R01AG065541, R01AG071465, and T32GM007752), the Shaffer Family Foundation and the Bruce Ford & Anne Smith Bundy Foundation.
We would love to give thanks to the author of this article for this awesome web content
";}s:7:"summary";s:625:"Journal Reference: Carter R. Palmer, Christine S. Liu, William J. Romanow, Ming-Hsiang Lee, Jerold Chun. Altered cell and RNA isoform diversity in aging Down syndrome brains. Proceedings of the National Academy of Sciences, 2021; 118 (47): e2114326118 DOI: 10.1073/pnas.2114326118 ?A stunningly high level of molecular and cellular diversity was found affecting single brain cells, which ... Read more";s:12:"atom_content";s:6060:"
Journal Reference:
Carter R. Palmer, Christine S. Liu, William J. Romanow, Ming-Hsiang Lee, Jerold Chun. Altered cell and RNA isoform diversity in aging Down syndrome brains. Proceedings of the National Academy of Sciences, 2021; 118 (47): e2114326118 DOI: 10.1073/pnas.2114326118
?A stunningly high level of molecular and cellular diversity was found affecting single brain cells, which provides new avenues for understanding both Down syndrome and Alzheimer?s disease,? says senior author Jerold Chun, M.D., Ph.D., professor and senior vice president of Neuroscience Drug Discovery at Sanford Burnham Prebys.
An old question requires new techniques
Down syndrome, also known as trisomy 21, occurs when the body has an extra copy of human chromosome 21, resulting in three copies instead of the usual two. Occurring in about one in 700 births, it is the most common chromosomal disorder. In addition to their lifelong cognitive challenges, all people with Down syndrome are exceptionally vulnerable to neurodegeneration later in life.
?By the time they?re in their 40s, every single person with Down syndrome will experience some Alzheimer?s pathology,? Chun says. ?We asked what happens in the brain before Alzheimer?s disease takes hold.?
While some of the genes and biochemical pathways involved in the development of Alzheimer?s in people with Down syndrome have been identified, the bigger picture ? the cellular and molecular changes that are responsible for triggering these pathways ? remains a mystery.
To investigate this question, Chun and his team analyzed 29 post-mortem Down syndrome brains using a method called single-nucleus transcriptomics, which looks at the RNA molecules within single cells. Because RNA encodes for proteins, knowing the RNA sequence reveals which proteins are likely being produced. And while this technique is being used widely in many fields, it has never been used in the Down syndrome brain. In addition, the paper represents the first published use of long-read sequencing in the human brain, a more accurate and less error-prone gene sequencing method.
?Our study revealed unappreciated changes in brain cell types involving hundreds of thousands of never-before-seen RNAs that can?t be seen using standard techniques,? says Chun. ?These can now be considered toward understanding the brain.?
The Down syndrome brain is a rich molecular landscape
The team found several unique aspects of the Down syndrome brain that could help pinpoint the origin of Down syndrome cognitive challenges and Alzheimer?s. First, they found that in Down syndrome, there are more inhibitory than excitatory neurons in the brain overall, meaning that there are more neurons that block the brain?s electrical signals than those that trigger them. They also found early and sustained increases in activated microglia, a type of brain cell that is an emerging target for treating common forms of Alzheimer?s disease.
?We could see these microglial features in young brains, well before Alzheimer?s occurs,? says Chun. ?This finding identifies microglia as a prominent and early player in the Down syndrome brain.?
The team also found special signatures in thousands of RNAs called intra-exonic junctions, where protein-coding sections of genetic material join together to form new molecules. These junctions had only been previously seen in one gene, called APP, alterations of which are thought to cause Alzheimer?s.
The presence of these junctions is consistent with a phenomenon in the brain called somatic gene recombination: when DNA becomes shuffled around into new gene combinations. Somatic gene recombination has previously been proposed by the researchers to operate in Alzheimer?s disease, and these new findings bolster this hypothesis.
?It will take more studies to confirm whether these novel RNAs reflect somatic gene recombination or come from some other source,? Chun says. ?But given what we?ve found before in Alzheimer?s brains, this new Down syndrome evidence points in that direction, and we are excited to investigate it further.?
The best may be yet to come
Although the work is far from over, the research is an unprecedented step forward in looking at the neurobiology of Down syndrome across the lifespan, creating new avenues of research.
?It?s wonderful that people with Down syndrome are living longer now than at any point in history, and we hope our research ultimately contributes to their improved quality of life at all ages,? says Chun. ?We are grateful to the brain donors, as well as their families, for helping our team and other researchers continue to shape our understanding of both Down syndrome and Alzheimer?s disease.?
Additional authors on the study include Carter R. Palmer, Christine S. Liu, William J. Romanow and Ming-Hsiang Lee, all from Chun?s lab at Sanford Burnham Prebys; Palmer and Liu are also students at the University of California, San Diego Biomedical Sciences Program.
The research was supported by funding from the National Institute on Aging, the National Institute of General Medical Sciences (NIH grants R56AG073965, R01AG065541, R01AG071465, and T32GM007752), the Shaffer Family Foundation and the Bruce Ford & Anne Smith Bundy Foundation.
We would love to give thanks to the author of this article for this awesome web content
";s:14:"date_timestamp";i:1637460568;}i:1;a:11:{s:5:"title";s:74:"MSXXI. The best phrases of Anthony Hopkins in Mexico XXI Century | VIDEO";s:4:"link";s:103:"https://wikileaksisdemocracy.org/msxxi-the-best-phrases-of-anthony-hopkins-in-mexico-xxi-century-video/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Sun, 21 Nov 2021 00:54:15 +0000";s:8:"category";s:56:"CelebrityAnthonyCenturyHopkinsMexicoMSXXIphrasesVideoXXI";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3592";s:11:"description";s:677:"Anthony Hopkins was one of the participants of Mexico XXI century, annual meeting of TELMEX Telcel Foundation with his fellows. Although his best known facet is that of an actor, Anthony Hopkins is also a composer, painter and pianist. Throughout his talk with journalist Pamela Cerdeira, the Oscar winner on two occasions shared with the ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4477:"
Anthony Hopkins was one of the participants of Mexico XXI century, annual meeting of TELMEX Telcel Foundation with his fellows.
Although his best known facet is that of an actor, Anthony Hopkins is also a composer, painter and pianist.
Throughout his talk with journalist Pamela Cerdeira, the Oscar winner on two occasions shared with the fellows some reflections and anecdotes about
Here we share some of the Anthony Hopkins Featured Quotes and MXXI.
“Humility really is a powerful ingredient because once you have it, then you can find true confidence to do whatever you want to do.”
“It is not the darkness that scares us, but our own greatness in the light.”
?The power is in being able to pull the reins of the ego. There are people who could not pull the reins and they became monsters because they thought they were God. So try to have a good balance between confidence, ego and excess. “
?I keep a photograph as a child. I see it and I say to that fearful child: we did it well boy, we did it well, we survived ?.
“Life is too short. We all have insecurities otherwise we would not be human, we would be sociopaths or automatons ?.
?It is none of my business what people say or think of me, I am what I am and I do what I do for fun, freely because I love doing it. There is nothing to gain, nothing to prove, nothing to lose. What makes me happy is just being alive. “
“Time is an illusion. When we look back, how can we prove that anything really happened? I am getting into metaphysics now but it is so wonderful. “
?I believe that you must have discipline, self-discipline. You also need confidence and know exactly what you are doing. Once you are disciplined and you know that you are trapped, then you are free. It’s totally amazing. “
?Doubt is the foundation of all belief. All I do is believe, believe and believe. Believe everything you want to believe ?.
?The whole universe is a mystery. We are made of the substance of the universe. I call it my higher consciousness. Living without some kind of fundamental belief in the mystery of life would be like living in a dark room with no windows.
?When you are an actor and you are young you believe the great thing. But I realized an inverse paradox: that I was insignificant. And with that you gain enormous freedom. It gave me space to do things for myself and do the things that I had been afraid to do. “
?There is a power within you that you don’t even begin to understand. Find the key, ask for it to be granted to you ?.
?I don’t know why I’m an actor, I have no idea. I don’t know where I come from. I don’t know what I’m doing here. I do not fight with the power that is within me. It is a great passion for me, not an escape. It is my affirmation of myself ?.
?I am not a psychologist, nor a philosopher, nor a neurosurgeon; But when I was a student, I told all my insecurities leave me alone. What I did was turn on the switch or put the key to the engine of my life ?.
?The immeasurable wonder of life itself along with its terrible beauty has kept me going. Life is a battle, a fight. It is a tough game. We have to fight and accept responsibility for our place in the scheme of things. “
“These are hard times. As we move through the challenges, we recover and survive. I think we’ll get out of this. Just believe that you can and you will. Believe in yourself ?.
We want to give thanks to the author of this post for this awesome content
";}s:7:"summary";s:677:"Anthony Hopkins was one of the participants of Mexico XXI century, annual meeting of TELMEX Telcel Foundation with his fellows. Although his best known facet is that of an actor, Anthony Hopkins is also a composer, painter and pianist. Throughout his talk with journalist Pamela Cerdeira, the Oscar winner on two occasions shared with the ... Read more";s:12:"atom_content";s:4477:"
Anthony Hopkins was one of the participants of Mexico XXI century, annual meeting of TELMEX Telcel Foundation with his fellows.
Although his best known facet is that of an actor, Anthony Hopkins is also a composer, painter and pianist.
Throughout his talk with journalist Pamela Cerdeira, the Oscar winner on two occasions shared with the fellows some reflections and anecdotes about
Here we share some of the Anthony Hopkins Featured Quotes and MXXI.
“Humility really is a powerful ingredient because once you have it, then you can find true confidence to do whatever you want to do.”
“It is not the darkness that scares us, but our own greatness in the light.”
?The power is in being able to pull the reins of the ego. There are people who could not pull the reins and they became monsters because they thought they were God. So try to have a good balance between confidence, ego and excess. “
?I keep a photograph as a child. I see it and I say to that fearful child: we did it well boy, we did it well, we survived ?.
“Life is too short. We all have insecurities otherwise we would not be human, we would be sociopaths or automatons ?.
?It is none of my business what people say or think of me, I am what I am and I do what I do for fun, freely because I love doing it. There is nothing to gain, nothing to prove, nothing to lose. What makes me happy is just being alive. “
“Time is an illusion. When we look back, how can we prove that anything really happened? I am getting into metaphysics now but it is so wonderful. “
?I believe that you must have discipline, self-discipline. You also need confidence and know exactly what you are doing. Once you are disciplined and you know that you are trapped, then you are free. It’s totally amazing. “
?Doubt is the foundation of all belief. All I do is believe, believe and believe. Believe everything you want to believe ?.
?The whole universe is a mystery. We are made of the substance of the universe. I call it my higher consciousness. Living without some kind of fundamental belief in the mystery of life would be like living in a dark room with no windows.
?When you are an actor and you are young you believe the great thing. But I realized an inverse paradox: that I was insignificant. And with that you gain enormous freedom. It gave me space to do things for myself and do the things that I had been afraid to do. “
?There is a power within you that you don’t even begin to understand. Find the key, ask for it to be granted to you ?.
?I don’t know why I’m an actor, I have no idea. I don’t know where I come from. I don’t know what I’m doing here. I do not fight with the power that is within me. It is a great passion for me, not an escape. It is my affirmation of myself ?.
?I am not a psychologist, nor a philosopher, nor a neurosurgeon; But when I was a student, I told all my insecurities leave me alone. What I did was turn on the switch or put the key to the engine of my life ?.
?The immeasurable wonder of life itself along with its terrible beauty has kept me going. Life is a battle, a fight. It is a tough game. We have to fight and accept responsibility for our place in the scheme of things. “
“These are hard times. As we move through the challenges, we recover and survive. I think we’ll get out of this. Just believe that you can and you will. Believe in yourself ?.
We want to give thanks to the author of this post for this awesome content
";s:14:"date_timestamp";i:1637456055;}i:2;a:11:{s:5:"title";s:48:"How ultracold, superdense atoms become invisible";s:4:"link";s:81:"https://wikileaksisdemocracy.org/how-ultracold-superdense-atoms-become-invisible/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 21 Nov 2021 00:52:49 +0000";s:8:"category";s:51:"Health And Scienceatomsinvisiblesuperdenseultracold";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3587";s:11:"description";s:628:"Journal Reference: Yair Margalit, Yu-Kun Lu, Furkan Ça?r? Top, Wolfgang Ketterle. Pauli blocking of light scattering in degenerate fermions. Science, 2021; 374 (6570): 976 DOI: 10.1126/science.abi6153 Now, MIT physicists have observed the Pauli exclusion principle, or Pauli blocking, in a completely new way: They?ve found that the effect can suppress how a cloud of atoms ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6721:"
Journal Reference:
Yair Margalit, Yu-Kun Lu, Furkan Ça?r? Top, Wolfgang Ketterle. Pauli blocking of light scattering in degenerate fermions. Science, 2021; 374 (6570): 976 DOI: 10.1126/science.abi6153
Now, MIT physicists have observed the Pauli exclusion principle, or Pauli blocking, in a completely new way: They?ve found that the effect can suppress how a cloud of atoms scatters light.
Normally, when photons of light penetrate a cloud of atoms, the particles can ping off each other like billiard balls, scattering photons in every direction to radiate light, and thus make the cloud visible. However, the MIT team observed that when atoms are supercooled and ultrasqueezed, the Pauli effect kicks in and the particles effectively have less room to scatter light. The photons instead stream through, without being scattered.
In their experiments, the physicists observed this effect in a cloud of lithium atoms. As they were made colder and more dense, the atoms scattered less light and became progressively dimmer. The researchers suspect that if they could push the conditions further, to temperatures of absolute zero, the cloud would become entirely invisible.
The team?s results, reported in Science, represent the first observation of Pauli blocking?s effect on light-scattering by atoms. This effect was predicted 30 years ago but not observed until now.
?Pauli blocking in general has been proven, and is absolutely essential for the stability of the world around us,? says Wolfgang Ketterle, the John D. Arthur Professor of Physics at MIT. ?What we?ve observed is one very special and simple form of Pauli blocking, which is that it prevents an atom from what all atoms would naturally do: scatter light. This is the first clear observation that this effect exists, and it shows a new phenomenon in physics.?
Ketterle?s co-authors are lead author and former MIT postdoc Yair Margalit, graduate student Yukun Lu, and Furkan Top PhD ?20. The team is affiliated with the MIT Physics Department, the MIT-Harvard Center for Ultracold Atoms, and MIT?s Research Laboratory of Electronics (RLE).
A light kick
When Ketterle came to MIT as a postdoc 30 years ago, his mentor, David Pritchard, the Cecil and Ida Green Professor of Physics, made a prediction that Pauli blocking would suppress the way certain atoms known as fermions scatter light.
His idea, broadly speaking, was that if atoms were frozen to a near standstill and squeezed into a tight enough space, the atoms would behave like electrons in packed energy shells, with no room to shift their velocity, or position. If photons of light were to stream in, they wouldn?t be able to scatter off and illuminate the atoms.
?An atom can only scatter a photon if it can absorb the force of its kick, by moving to another chair,? explains Ketterle, invoking the arena seating analogy. ?If all other chairs are occupied, it no longer has the ability to absorb the kick and scatter the photon. So, the atom becomes transparent.?
?This phenomenon had never been observed before, because people were not able to generate clouds that were cold and dense enough,? Ketterle adds.
?Controlling the atomic world?
In recent years, physicists including those in Ketterle?s group have developed magnetic and laser-based techniques to bring atoms down to ultracold temperatures. The limiting factor, he says, was density.
?If the density is not high enough, an atom can still scatter light by jumping over a few chairs until it finds some room,? Ketterle says. ?That was the bottleneck.?
In their new study, he and his colleagues used techniques they developed previously to first freeze a cloud of fermions ? in this case, a special isotope of lithium atom, which has three electrons, three protons, and three neutrons. They froze a cloud of lithium atoms down to 20 microkelvins, which is about 1/100,000 the temperature of interstellar space.
?We then used a tightly focused laser to squeeze the ultracold atoms to record densities, which reached about a quadrillion atoms per cubic centimeter,? Lu explains.
The researchers then shone another laser beam into the cloud, which they carefully calibrated so that its photons would not heat up the ultracold atoms or alter their density as the light passed through. Finally, they used a lens and camera to capture and count the photons that managed to scatter away.
?We?re actually counting a few hundred photons, which is really amazing,? Margalit says. ?A photon is such a little amount of light, but our equipment is so sensitive that we can see them as a small blob of light on the camera.?
At progressively colder temperatures and higher densities, the atoms scattered less and less light, just as Pritchard?s theory predicted. At their coldest, at around 20 microkelvin, the atoms were 38 percent dimmer, meaning they scattered 38 percent less light than less cold, less dense atoms.
?This regime of ultracold and very dense clouds has other effects that could possibly deceive us,? Margalit says. ?So, we spent a few good months sifting through and putting aside these effects, to get the clearest measurement.?
Now that the team has observed Pauli blocking can indeed affect an atom?s ability to scatter light, Ketterle says this fundamental knowledge may be used to develop light-suppressing materials, for instance to preserve data in quantum computers.
?Whenever we control the quantum world, like in quantum computers, light scattering is a problem, and means that information is leaking out of your quantum computer,? he muses. ?This is one way to suppress light scattering, and we are contributing to the general theme of controlling the atomic world.?
This research was funded, in part, by the National Science Foundation and the Department of Defense. Related work by a team from the University of Colorado appears in the same issue of Science.
We want to say thanks to the author of this write-up for this incredible web content
";}s:7:"summary";s:628:"Journal Reference: Yair Margalit, Yu-Kun Lu, Furkan Ça?r? Top, Wolfgang Ketterle. Pauli blocking of light scattering in degenerate fermions. Science, 2021; 374 (6570): 976 DOI: 10.1126/science.abi6153 Now, MIT physicists have observed the Pauli exclusion principle, or Pauli blocking, in a completely new way: They?ve found that the effect can suppress how a cloud of atoms ... Read more";s:12:"atom_content";s:6721:"
Journal Reference:
Yair Margalit, Yu-Kun Lu, Furkan Ça?r? Top, Wolfgang Ketterle. Pauli blocking of light scattering in degenerate fermions. Science, 2021; 374 (6570): 976 DOI: 10.1126/science.abi6153
Now, MIT physicists have observed the Pauli exclusion principle, or Pauli blocking, in a completely new way: They?ve found that the effect can suppress how a cloud of atoms scatters light.
Normally, when photons of light penetrate a cloud of atoms, the particles can ping off each other like billiard balls, scattering photons in every direction to radiate light, and thus make the cloud visible. However, the MIT team observed that when atoms are supercooled and ultrasqueezed, the Pauli effect kicks in and the particles effectively have less room to scatter light. The photons instead stream through, without being scattered.
In their experiments, the physicists observed this effect in a cloud of lithium atoms. As they were made colder and more dense, the atoms scattered less light and became progressively dimmer. The researchers suspect that if they could push the conditions further, to temperatures of absolute zero, the cloud would become entirely invisible.
The team?s results, reported in Science, represent the first observation of Pauli blocking?s effect on light-scattering by atoms. This effect was predicted 30 years ago but not observed until now.
?Pauli blocking in general has been proven, and is absolutely essential for the stability of the world around us,? says Wolfgang Ketterle, the John D. Arthur Professor of Physics at MIT. ?What we?ve observed is one very special and simple form of Pauli blocking, which is that it prevents an atom from what all atoms would naturally do: scatter light. This is the first clear observation that this effect exists, and it shows a new phenomenon in physics.?
Ketterle?s co-authors are lead author and former MIT postdoc Yair Margalit, graduate student Yukun Lu, and Furkan Top PhD ?20. The team is affiliated with the MIT Physics Department, the MIT-Harvard Center for Ultracold Atoms, and MIT?s Research Laboratory of Electronics (RLE).
A light kick
When Ketterle came to MIT as a postdoc 30 years ago, his mentor, David Pritchard, the Cecil and Ida Green Professor of Physics, made a prediction that Pauli blocking would suppress the way certain atoms known as fermions scatter light.
His idea, broadly speaking, was that if atoms were frozen to a near standstill and squeezed into a tight enough space, the atoms would behave like electrons in packed energy shells, with no room to shift their velocity, or position. If photons of light were to stream in, they wouldn?t be able to scatter off and illuminate the atoms.
?An atom can only scatter a photon if it can absorb the force of its kick, by moving to another chair,? explains Ketterle, invoking the arena seating analogy. ?If all other chairs are occupied, it no longer has the ability to absorb the kick and scatter the photon. So, the atom becomes transparent.?
?This phenomenon had never been observed before, because people were not able to generate clouds that were cold and dense enough,? Ketterle adds.
?Controlling the atomic world?
In recent years, physicists including those in Ketterle?s group have developed magnetic and laser-based techniques to bring atoms down to ultracold temperatures. The limiting factor, he says, was density.
?If the density is not high enough, an atom can still scatter light by jumping over a few chairs until it finds some room,? Ketterle says. ?That was the bottleneck.?
In their new study, he and his colleagues used techniques they developed previously to first freeze a cloud of fermions ? in this case, a special isotope of lithium atom, which has three electrons, three protons, and three neutrons. They froze a cloud of lithium atoms down to 20 microkelvins, which is about 1/100,000 the temperature of interstellar space.
?We then used a tightly focused laser to squeeze the ultracold atoms to record densities, which reached about a quadrillion atoms per cubic centimeter,? Lu explains.
The researchers then shone another laser beam into the cloud, which they carefully calibrated so that its photons would not heat up the ultracold atoms or alter their density as the light passed through. Finally, they used a lens and camera to capture and count the photons that managed to scatter away.
?We?re actually counting a few hundred photons, which is really amazing,? Margalit says. ?A photon is such a little amount of light, but our equipment is so sensitive that we can see them as a small blob of light on the camera.?
At progressively colder temperatures and higher densities, the atoms scattered less and less light, just as Pritchard?s theory predicted. At their coldest, at around 20 microkelvin, the atoms were 38 percent dimmer, meaning they scattered 38 percent less light than less cold, less dense atoms.
?This regime of ultracold and very dense clouds has other effects that could possibly deceive us,? Margalit says. ?So, we spent a few good months sifting through and putting aside these effects, to get the clearest measurement.?
Now that the team has observed Pauli blocking can indeed affect an atom?s ability to scatter light, Ketterle says this fundamental knowledge may be used to develop light-suppressing materials, for instance to preserve data in quantum computers.
?Whenever we control the quantum world, like in quantum computers, light scattering is a problem, and means that information is leaking out of your quantum computer,? he muses. ?This is one way to suppress light scattering, and we are contributing to the general theme of controlling the atomic world.?
This research was funded, in part, by the National Science Foundation and the Department of Defense. Related work by a team from the University of Colorado appears in the same issue of Science.
We want to say thanks to the author of this write-up for this incredible web content
";s:14:"date_timestamp";i:1637455969;}i:3;a:11:{s:5:"title";s:61:"ADI 2021 Best Video Clip Judging is Fierce: Okezone Celebrity";s:4:"link";s:94:"https://wikileaksisdemocracy.org/adi-2021-best-video-clip-judging-is-fierce-okezone-celebrity/";s:2:"dc";a:1:{s:7:"creator";s:11:"David Lonit";}s:7:"pubdate";s:31:"Sun, 21 Nov 2021 00:47:05 +0000";s:8:"category";s:46:"ShowsADICelebrityClipFierceJudgingOkezoneVideo";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3581";s:11:"description";s:626:"JAKARTA – Being chosen to be the best in a prestigious event like the Anugerah Dangdut Indonesia (ADI) is the dream of every nominee in the nomination. There are 94 nominations at ADI 2021 for 12 award categories, consisting of 7 most popular categories, 4 best categories chosen by judges and 1 lifetime achievement category. ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5235:"
JAKARTA – Being chosen to be the best in a prestigious event like the Anugerah Dangdut Indonesia (ADI) is the dream of every nominee in the nomination.
There are 94 nominations at ADI 2021 for 12 award categories, consisting of 7 most popular categories, 4 best categories chosen by judges and 1 lifetime achievement category. The nominees were selected from music charts from dozens of radios throughout Indonesia and Youtube viewers during the period
A few days ago (17/11) the judges were judged directly by the judges, namely Koko Thole, Ine Shyntia, Endah Hari Utari as MNCTV Programming Director and John Fair as MNCTV’s VP Special Program & Awarding for the 4 categories. It takes quite a long time to assess and determine who and which one will be chosen to be the best.
There was a debate between the judges in determining who was the best, the debate lasted quite a long time in determining the best video category. However, it can be handled well by the jury.
Meanwhile, the nominations for other categories are also filled with big names who are ready to be horrendous at the 2021 Indonesian Dangdut Award later. The following is the complete list of nominees for the 2021 Indonesian Dangdut Award (ADI):
Best Dangdut Song Category
Past Wind ? Danang, Creator – Danang
Take Me to the Penghulu ? Lesti Kejora, Creator – Adibal Sahrul
When Will Separate ? Wahid KDI, Creator – Muhammad Roma
Sorry I’m Gone ? Evi Masamba, Creator – Michael Widyatmaka & Vivie Chang
As Beautiful as the Rainbow ? Inul Daratista, Creator – Adibal Sharul
No Return ? Ikke Nurjanah, Creator ? Fauzi Bima
Tatitut – Ayu Ting Ting, Creator of Yogi RPH
Best Male Dangdut Singer Category
Adibal Sahrul
Danang
Denny Caknan
Fildan
Nassar
Ndarboy Genk
Wandra
Best Female Dangdut Singer Category
Ayu Ting Ting |
Evi Masamba
Happy Romance
Not Nurjanah
Inul Daratista
Ready Kejora
Via Vallen
Best Dangdut Video Clip Category
Adibalmusic Production, Lesti Kejor – Bawa aku Penghul
Arya Teja, Risa KDI – Stage Princess
Krisnkros, Denny Caknan Ft. Cak Percil – Angel
Official Music Video Nagaswara X Ronyrom Production, Sandrina – After Drinking What
Henry Habayahan, Inul Daratista – As Beautiful as the Rainbow
In addition, the 7 most popular categories are “Male Dangdut Singer Most In Heart”, “Most Female Dangdut Singer in Heart”, “Most Dangdut Newcomer Singer in Heart”, “Duo/Trio/Group Dangdut Apling in Heart”, “Most Popular Dangdut Collaboration” Heart”, “Most Dangdut Song in the Heart” and “Most Popdut in the Heart”. Support your favorite dangdut singer through the RCTI+ application, then comment on Instagram @officialmnctv by typing #VOTEADI2021(SPACE)NOMINATION CODE in the category photo that has been uploaded to the MNCTV official account. Voting has been open since November 8 and voting is valid until November 23, 2021.
Watch the 2021 Indonesian Dangdut Award which will be broadcast LIVE on Wednesday, November 24 at 19.30 WIB at Studio RCTI+ MNC Studios, Kebon Jeruk, West Jakarta. Only on MNCTV, Always in the heart.
We wish to thank the author of this article for this incredible web content
";}s:7:"summary";s:626:"JAKARTA – Being chosen to be the best in a prestigious event like the Anugerah Dangdut Indonesia (ADI) is the dream of every nominee in the nomination. There are 94 nominations at ADI 2021 for 12 award categories, consisting of 7 most popular categories, 4 best categories chosen by judges and 1 lifetime achievement category. ... Read more";s:12:"atom_content";s:5235:"
JAKARTA – Being chosen to be the best in a prestigious event like the Anugerah Dangdut Indonesia (ADI) is the dream of every nominee in the nomination.
There are 94 nominations at ADI 2021 for 12 award categories, consisting of 7 most popular categories, 4 best categories chosen by judges and 1 lifetime achievement category. The nominees were selected from music charts from dozens of radios throughout Indonesia and Youtube viewers during the period
A few days ago (17/11) the judges were judged directly by the judges, namely Koko Thole, Ine Shyntia, Endah Hari Utari as MNCTV Programming Director and John Fair as MNCTV’s VP Special Program & Awarding for the 4 categories. It takes quite a long time to assess and determine who and which one will be chosen to be the best.
There was a debate between the judges in determining who was the best, the debate lasted quite a long time in determining the best video category. However, it can be handled well by the jury.
Meanwhile, the nominations for other categories are also filled with big names who are ready to be horrendous at the 2021 Indonesian Dangdut Award later. The following is the complete list of nominees for the 2021 Indonesian Dangdut Award (ADI):
Best Dangdut Song Category
Past Wind ? Danang, Creator – Danang
Take Me to the Penghulu ? Lesti Kejora, Creator – Adibal Sahrul
When Will Separate ? Wahid KDI, Creator – Muhammad Roma
Sorry I’m Gone ? Evi Masamba, Creator – Michael Widyatmaka & Vivie Chang
As Beautiful as the Rainbow ? Inul Daratista, Creator – Adibal Sharul
No Return ? Ikke Nurjanah, Creator ? Fauzi Bima
Tatitut – Ayu Ting Ting, Creator of Yogi RPH
Best Male Dangdut Singer Category
Adibal Sahrul
Danang
Denny Caknan
Fildan
Nassar
Ndarboy Genk
Wandra
Best Female Dangdut Singer Category
Ayu Ting Ting |
Evi Masamba
Happy Romance
Not Nurjanah
Inul Daratista
Ready Kejora
Via Vallen
Best Dangdut Video Clip Category
Adibalmusic Production, Lesti Kejor – Bawa aku Penghul
Arya Teja, Risa KDI – Stage Princess
Krisnkros, Denny Caknan Ft. Cak Percil – Angel
Official Music Video Nagaswara X Ronyrom Production, Sandrina – After Drinking What
Henry Habayahan, Inul Daratista – As Beautiful as the Rainbow
In addition, the 7 most popular categories are “Male Dangdut Singer Most In Heart”, “Most Female Dangdut Singer in Heart”, “Most Dangdut Newcomer Singer in Heart”, “Duo/Trio/Group Dangdut Apling in Heart”, “Most Popular Dangdut Collaboration” Heart”, “Most Dangdut Song in the Heart” and “Most Popdut in the Heart”. Support your favorite dangdut singer through the RCTI+ application, then comment on Instagram @officialmnctv by typing #VOTEADI2021(SPACE)NOMINATION CODE in the category photo that has been uploaded to the MNCTV official account. Voting has been open since November 8 and voting is valid until November 23, 2021.
Watch the 2021 Indonesian Dangdut Award which will be broadcast LIVE on Wednesday, November 24 at 19.30 WIB at Studio RCTI+ MNC Studios, Kebon Jeruk, West Jakarta. Only on MNCTV, Always in the heart.
We wish to thank the author of this article for this incredible web content
";s:14:"date_timestamp";i:1637455625;}i:4;a:11:{s:5:"title";s:88:"Chet Baker: jazz, magic and mysteries in a film. Pieranunzi: ?He was a magnetic genius?";s:4:"link";s:115:"https://wikileaksisdemocracy.org/chet-baker-jazz-magic-and-mysteries-in-a-film-pieranunzi-he-was-a-magnetic-genius/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Sun, 21 Nov 2021 00:41:04 +0000";s:8:"category";s:60:"ShowsBakerChetfilmgeniusJAZZmagicmagneticmysteriesPieranunzi";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3577";s:11:"description";s:757:"“Jazz Noir – Investigation into the mysterious death of the legendary Chet” (Wanted Cinema), the film about Chet Baker premiered yesterday in Milan which from 22 to 24 November will be screened for the first time in Italian cinemas (on wantedcinema.eu l ‘list of participating cities). Drug addiction, demons, women: a noir that starts from ... Read more";s:7:"content";a:1:{s:7:"encoded";s:8775:"
“Jazz Noir – Investigation into the mysterious death of the legendary Chet” (Wanted Cinema), the film about Chet Baker premiered yesterday in Milan which from 22 to 24 November will be screened for the first time in Italian cinemas (on wantedcinema.eu l ‘list of participating cities). Drug addiction, demons, women: a noir that starts from the death of one of the most important exponents of cool jazz, which occurred when he fell from the window of a room in the Prins Hendrik Hotel, in the red light district of Amsterdam, on 13 May 1988. A suicide or a fatal cocktail that made him mistake a window for a door? The music is taken from original recordings, while the direction is by the Dutch Rolf van Eijk. To play Chet, actor Steve Wall (?Vikings?, ?The Witcher?), frontman of the band The Walls and The Stunning. The screenings in Milan (Anteo, Multisala Eliseo and Wanted Clan) are included in the program of the Milan Music Week 2021 (from 22 to 28 November).
The biopic dedicated to Chet Baker “JAZZ NOIR – Investigation into the mysterious death of the legendary Chet” arrives in Italy
Chet Baker, Pieranunzi: “A magnetic genius forced you to play better”
Chet Baker, Pietropaoli: “He was both sweet and cynical”
Chet Baker, Roberto Gatto: “At 200 per hour by car in the snow”
THE DOUBLE BASS PLAYER PIETROPAOLI: “IT WAS TOGETHER SWEET AND CYNIC”
?Unfortunately, it is often remembered first of all for drugs. But until the end, Chet Baker was one of the greatest trumpet players in the history of jazz ». It is Enzo Pietropaoli who tells. The famous double bass player with Baker recorded “Chet on Poetry” and “Little girl Blue”, the last work in the studio two months after his death.
First image that comes to mind? “His face. His expression. His efforts, especially in recent years, to look for the notes on the trumpet. With effort and suffering he produced unforgettable moments of pure art ».
When did you start working with him? “In the 80s. They called me to replace the double bass player. For me it was the realization of a dream ».
Suicide or something? ?I don’t think he felt like committing suicide. Maybe he had a sense of suffocation due to drug addiction problems. Why do you do it? I asked him once. Because I like it, he replied. He was someone who had dignity, even when he asked for money. And when he was well, he was kind. ‘
What do you remember outside of music? ?His ability to drive, to repair cars. It made practical sense. He often turned with his daughter Missy: towards her, love and detachment. Sweetness and cynicism. As was he ».
A phrase? «Enzo, remember that what matters about a solo is how it begins and how it ends. He was right”.
THE GATTO DRUMMER: “WITH HIM IN THE CAR AT 200 KM PER HOUR UNDER THE SNOW”
“He had the virtue of listening to the others on stage.” Drummer Roberto Gatto is among the musicians who have collaborated most with Chet Baker. Concerts throughout the European period, recording “Soft Journey” and “Chet on Poetry”. “I started working with him when I was 18”.
Is it true that you didn’t like drummers? “True. I had entered into his sympathies. I played with him until the concert in Turin, a few days before he died. He was stopped at the border, methadone was found. He arrived very late. He punched me on the back and said “I have no problem playing with you.” It was the last time I saw him. Hate was a question of dynamics: the drummers play strong, he had the problem of pushing the sound (he lost his teeth due to the aggression he received, ed) ».
Anecdotes? ?He loved cars. One day he picked me up in Bonn. We charged the battery and set off under a blizzard. He was going 200km per hour, smoking joint and listening to Weather Report. I made the sign of the cross. And when after the concerts he had to pay us, he would show up with a bundle of dollars, if you were distracted for a moment he would fool you (laughs, ed) ».
You played in the prison of Lucca in the cell where you were imprisoned. ?During a tribute. It was exciting. He was well-liked there too. He was a genius. ”
PIERANUNZI: “HE WAS A MAGNETIC GENIUS, PUSHED YOU TO PLAY BETTER”
«An extraordinary genius. The meeting with him. It changed my life. I learned minimalism from him ». Pianist Enrico Pieranunzi has vivid images when he talks about Chet Baker: music, prison, drug addiction, debts, and women, Diane, to whom he dedicates the famous album, and singer Ruth Young. «I started to know him in the 50s, when I listened to his records with Gerry Mulligan, the songs Carioca and Line for Lyons».
What person was he? “Magnetic. With that lyrical and inexorably right phrasing, he forced you to play better ».
When did you meet him? «In ’79, after the” crime “of the teeth. It was a miracle for a trumpet player to play at that level with dentures. They called me for a live in the Marche with Roberto Gatto and Riccardo del Fra. I brazenly asked him to make a record. Thus was born “Soft Journey”, an album written for him and now unobtainable. ?Soft?, for the softness of its sound. He was called the best of those he recorded in Europe. The song “Night Bird” took him all over the world. Paul, one of his sons, forcefully claimed the rights. But the original contract exists ».
The record boasts the liner notes. ?I wanted him to write to you. He had never done this before. He made me find them with a note in the handwriting of impressive regularity at the Anglo Americano Hotel in Rome. The date is January 10, 1980, a few days after having recorded as a duo, ?My Funny Valentine?. For me, a relic ».
A false legend? ?Just that he couldn’t read the notes. Instead he knew them well. The peculiarity of Chet was his incredible ear: a single note was enough for him to play the entire score ».
The other album together is “Silence”. «By Charlie Haden, for some of the 100 jazz records to be saved. Chet there was bad. He couldn’t stand up. Diane was in the studio. It was difficult to record it ».
Was it suicide? “I do not believe. Drug addiction seeks addiction, which is a reason for living. He was very good both in dosages and in the choice of suppliers ».
It is said that he asked anyone for money. «He also asked me for them. The day Bill Evans died. It was he who revealed to me that the cause of death was cocaine and not the ulcer, as was then written. I gave him 400 thousand lire. He then returned 200 to my father. Unlike Evans, Chet did not hide the addiction. Music saved his life. He sounded like that despite the drugs. In America they remember him as a “druggy” (drug addict). In Europe, like a talent ».
“The Heart of the Ballad” and “Little Girl Blue” were the last records. And you recorded them together. ?A day away. I last saw him at Ray Bryant’s concert at the Big Mama in Rome where he said he had just finished making a good record. He called me master, embarrassing me. With him, a very strong and silent relationship ».
";}s:7:"summary";s:757:"“Jazz Noir – Investigation into the mysterious death of the legendary Chet” (Wanted Cinema), the film about Chet Baker premiered yesterday in Milan which from 22 to 24 November will be screened for the first time in Italian cinemas (on wantedcinema.eu l ‘list of participating cities). Drug addiction, demons, women: a noir that starts from ... Read more";s:12:"atom_content";s:8775:"
“Jazz Noir – Investigation into the mysterious death of the legendary Chet” (Wanted Cinema), the film about Chet Baker premiered yesterday in Milan which from 22 to 24 November will be screened for the first time in Italian cinemas (on wantedcinema.eu l ‘list of participating cities). Drug addiction, demons, women: a noir that starts from the death of one of the most important exponents of cool jazz, which occurred when he fell from the window of a room in the Prins Hendrik Hotel, in the red light district of Amsterdam, on 13 May 1988. A suicide or a fatal cocktail that made him mistake a window for a door? The music is taken from original recordings, while the direction is by the Dutch Rolf van Eijk. To play Chet, actor Steve Wall (?Vikings?, ?The Witcher?), frontman of the band The Walls and The Stunning. The screenings in Milan (Anteo, Multisala Eliseo and Wanted Clan) are included in the program of the Milan Music Week 2021 (from 22 to 28 November).
The biopic dedicated to Chet Baker “JAZZ NOIR – Investigation into the mysterious death of the legendary Chet” arrives in Italy
Chet Baker, Pieranunzi: “A magnetic genius forced you to play better”
Chet Baker, Pietropaoli: “He was both sweet and cynical”
Chet Baker, Roberto Gatto: “At 200 per hour by car in the snow”
THE DOUBLE BASS PLAYER PIETROPAOLI: “IT WAS TOGETHER SWEET AND CYNIC”
?Unfortunately, it is often remembered first of all for drugs. But until the end, Chet Baker was one of the greatest trumpet players in the history of jazz ». It is Enzo Pietropaoli who tells. The famous double bass player with Baker recorded “Chet on Poetry” and “Little girl Blue”, the last work in the studio two months after his death.
First image that comes to mind? “His face. His expression. His efforts, especially in recent years, to look for the notes on the trumpet. With effort and suffering he produced unforgettable moments of pure art ».
When did you start working with him? “In the 80s. They called me to replace the double bass player. For me it was the realization of a dream ».
Suicide or something? ?I don’t think he felt like committing suicide. Maybe he had a sense of suffocation due to drug addiction problems. Why do you do it? I asked him once. Because I like it, he replied. He was someone who had dignity, even when he asked for money. And when he was well, he was kind. ‘
What do you remember outside of music? ?His ability to drive, to repair cars. It made practical sense. He often turned with his daughter Missy: towards her, love and detachment. Sweetness and cynicism. As was he ».
A phrase? «Enzo, remember that what matters about a solo is how it begins and how it ends. He was right”.
THE GATTO DRUMMER: “WITH HIM IN THE CAR AT 200 KM PER HOUR UNDER THE SNOW”
“He had the virtue of listening to the others on stage.” Drummer Roberto Gatto is among the musicians who have collaborated most with Chet Baker. Concerts throughout the European period, recording “Soft Journey” and “Chet on Poetry”. “I started working with him when I was 18”.
Is it true that you didn’t like drummers? “True. I had entered into his sympathies. I played with him until the concert in Turin, a few days before he died. He was stopped at the border, methadone was found. He arrived very late. He punched me on the back and said “I have no problem playing with you.” It was the last time I saw him. Hate was a question of dynamics: the drummers play strong, he had the problem of pushing the sound (he lost his teeth due to the aggression he received, ed) ».
Anecdotes? ?He loved cars. One day he picked me up in Bonn. We charged the battery and set off under a blizzard. He was going 200km per hour, smoking joint and listening to Weather Report. I made the sign of the cross. And when after the concerts he had to pay us, he would show up with a bundle of dollars, if you were distracted for a moment he would fool you (laughs, ed) ».
You played in the prison of Lucca in the cell where you were imprisoned. ?During a tribute. It was exciting. He was well-liked there too. He was a genius. ”
PIERANUNZI: “HE WAS A MAGNETIC GENIUS, PUSHED YOU TO PLAY BETTER”
«An extraordinary genius. The meeting with him. It changed my life. I learned minimalism from him ». Pianist Enrico Pieranunzi has vivid images when he talks about Chet Baker: music, prison, drug addiction, debts, and women, Diane, to whom he dedicates the famous album, and singer Ruth Young. «I started to know him in the 50s, when I listened to his records with Gerry Mulligan, the songs Carioca and Line for Lyons».
What person was he? “Magnetic. With that lyrical and inexorably right phrasing, he forced you to play better ».
When did you meet him? «In ’79, after the” crime “of the teeth. It was a miracle for a trumpet player to play at that level with dentures. They called me for a live in the Marche with Roberto Gatto and Riccardo del Fra. I brazenly asked him to make a record. Thus was born “Soft Journey”, an album written for him and now unobtainable. ?Soft?, for the softness of its sound. He was called the best of those he recorded in Europe. The song “Night Bird” took him all over the world. Paul, one of his sons, forcefully claimed the rights. But the original contract exists ».
The record boasts the liner notes. ?I wanted him to write to you. He had never done this before. He made me find them with a note in the handwriting of impressive regularity at the Anglo Americano Hotel in Rome. The date is January 10, 1980, a few days after having recorded as a duo, ?My Funny Valentine?. For me, a relic ».
A false legend? ?Just that he couldn’t read the notes. Instead he knew them well. The peculiarity of Chet was his incredible ear: a single note was enough for him to play the entire score ».
The other album together is “Silence”. «By Charlie Haden, for some of the 100 jazz records to be saved. Chet there was bad. He couldn’t stand up. Diane was in the studio. It was difficult to record it ».
Was it suicide? “I do not believe. Drug addiction seeks addiction, which is a reason for living. He was very good both in dosages and in the choice of suppliers ».
It is said that he asked anyone for money. «He also asked me for them. The day Bill Evans died. It was he who revealed to me that the cause of death was cocaine and not the ulcer, as was then written. I gave him 400 thousand lire. He then returned 200 to my father. Unlike Evans, Chet did not hide the addiction. Music saved his life. He sounded like that despite the drugs. In America they remember him as a “druggy” (drug addict). In Europe, like a talent ».
“The Heart of the Ballad” and “Little Girl Blue” were the last records. And you recorded them together. ?A day away. I last saw him at Ray Bryant’s concert at the Big Mama in Rome where he said he had just finished making a good record. He called me master, embarrassing me. With him, a very strong and silent relationship ».
";s:14:"date_timestamp";i:1637455264;}i:5;a:11:{s:5:"title";s:48:"Food scientists create zinc index for human body";s:4:"link";s:82:"https://wikileaksisdemocracy.org/food-scientists-create-zinc-index-for-human-body/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 20 Nov 2021 23:36:05 +0000";s:8:"category";s:51:"Health And SciencebodycreateFoodhumanScientistszinc";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3572";s:11:"description";s:635:"Journal Reference: Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status. Nutrients, 2021; 13 (10): 3399 DOI: 10.3390/nu13103399 To accurately calculate from biomarkers the physiological status of a subject, Cornell food scientists have developed a new evaluation method: the Zinc Status Index. The human body needs zinc to ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4160:"
Journal Reference:
Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status. Nutrients, 2021; 13 (10): 3399 DOI: 10.3390/nu13103399
To accurately calculate from biomarkers the physiological status of a subject, Cornell food scientists have developed a new evaluation method: the Zinc Status Index.
The human body needs zinc to boost immunity, regulate metabolism and to help heal wounds, but more than 1 billion people ? or about 17% of the global population ? suffer from dietary zinc deficiency. The World Health Organization asked the world?s scientists to create such a robust test to determine ? accurately ? if someone is zinc deficient.
?With global food insecurity and increasing domestic obesity rates, malnutrition is hitting vulnerable and low-income populations. These issues are a major concern, as they can lead to dietary zinc deficiency,? said Elad Tako, associate professor of food science in the College of Agriculture and Life Sciences, who developed the index with first author Jacquelyn Cheng ?15, doctoral student in food science, and Haim Bar M.S. ?10, Ph.D. ?12, associate professor, University of Connecticut. ?Because of the complexity and sophistication of zinc metabolism, it is very difficult to accurately measure zinc status.?
The paper, ?Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status,? is reported in the Sept. 27 journal Nutrients.
?This research presents a significant advancement in the field of zinc nutrition and the associated physiological status,? Cheng said. ?Using the Zinc Status Index will provide a better understanding of the challenges that are linked to poor zinc nutrition, and improve the ability to quantify the impact of dietary interventions aimed at alleviating zinc deficiency.?
The Zinc Status Index incorporates a statistical model and hinges on three pillars:
The ratio of linolenic acid, a fatty acid, to dihomo-gamma-linolenic acid ratio, another fatty acid ? known as the LA:DGLA ratio, a Cornell-developed biomarker reported in 2014 by the Tako lab team (Spenser Reed ?14, first author) ? indicating the subject?s physiological status;
Gene expression of zinc dependent proteins, that are affected by zinc status; and
The gut microbiome as an additional tool to reflect zinc physiological status.
Further, Tako?s group showed that mild zinc deficiency could alter gene expression in the body, and that the intestine?s microbial environment is crucial for zinc metabolism. A lack of zinc adversely affects the composition of intestinal microbial populations.
It is possible to detect severe zinc deficiency, Tako said. ?However, it is difficult to differentiate between mild and moderate cases of zinc deficiency,? he said. ?Therefore, relying on only one biomarker may sometimes be an issue, which has led us to think how we could develop an accurate zinc status index, based on a panel of predictive biomarkers.?
Tako is concerned about undernourishment around the world and over nourishment in the United States. Undernourishment can bring about zinc deficiency globally, particularly among vulnerable populations, including children. ?Malnutrition is something that is becoming more of an issue in the U.S.,? he said, ?particularly the double burden of malnutrition that basically connects obesity and mineral deficiencies, which means zinc and iron.?
We wish to give thanks to the writer of this post for this remarkable web content
";}s:7:"summary";s:635:"Journal Reference: Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status. Nutrients, 2021; 13 (10): 3399 DOI: 10.3390/nu13103399 To accurately calculate from biomarkers the physiological status of a subject, Cornell food scientists have developed a new evaluation method: the Zinc Status Index. The human body needs zinc to ... Read more";s:12:"atom_content";s:4160:"
Journal Reference:
Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status. Nutrients, 2021; 13 (10): 3399 DOI: 10.3390/nu13103399
To accurately calculate from biomarkers the physiological status of a subject, Cornell food scientists have developed a new evaluation method: the Zinc Status Index.
The human body needs zinc to boost immunity, regulate metabolism and to help heal wounds, but more than 1 billion people ? or about 17% of the global population ? suffer from dietary zinc deficiency. The World Health Organization asked the world?s scientists to create such a robust test to determine ? accurately ? if someone is zinc deficient.
?With global food insecurity and increasing domestic obesity rates, malnutrition is hitting vulnerable and low-income populations. These issues are a major concern, as they can lead to dietary zinc deficiency,? said Elad Tako, associate professor of food science in the College of Agriculture and Life Sciences, who developed the index with first author Jacquelyn Cheng ?15, doctoral student in food science, and Haim Bar M.S. ?10, Ph.D. ?12, associate professor, University of Connecticut. ?Because of the complexity and sophistication of zinc metabolism, it is very difficult to accurately measure zinc status.?
The paper, ?Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status,? is reported in the Sept. 27 journal Nutrients.
?This research presents a significant advancement in the field of zinc nutrition and the associated physiological status,? Cheng said. ?Using the Zinc Status Index will provide a better understanding of the challenges that are linked to poor zinc nutrition, and improve the ability to quantify the impact of dietary interventions aimed at alleviating zinc deficiency.?
The Zinc Status Index incorporates a statistical model and hinges on three pillars:
The ratio of linolenic acid, a fatty acid, to dihomo-gamma-linolenic acid ratio, another fatty acid ? known as the LA:DGLA ratio, a Cornell-developed biomarker reported in 2014 by the Tako lab team (Spenser Reed ?14, first author) ? indicating the subject?s physiological status;
Gene expression of zinc dependent proteins, that are affected by zinc status; and
The gut microbiome as an additional tool to reflect zinc physiological status.
Further, Tako?s group showed that mild zinc deficiency could alter gene expression in the body, and that the intestine?s microbial environment is crucial for zinc metabolism. A lack of zinc adversely affects the composition of intestinal microbial populations.
It is possible to detect severe zinc deficiency, Tako said. ?However, it is difficult to differentiate between mild and moderate cases of zinc deficiency,? he said. ?Therefore, relying on only one biomarker may sometimes be an issue, which has led us to think how we could develop an accurate zinc status index, based on a panel of predictive biomarkers.?
Tako is concerned about undernourishment around the world and over nourishment in the United States. Undernourishment can bring about zinc deficiency globally, particularly among vulnerable populations, including children. ?Malnutrition is something that is becoming more of an issue in the U.S.,? he said, ?particularly the double burden of malnutrition that basically connects obesity and mineral deficiencies, which means zinc and iron.?
We wish to give thanks to the writer of this post for this remarkable web content
";s:14:"date_timestamp";i:1637451365;}i:6;a:11:{s:5:"title";s:77:"Qatar, Hamilton?s pole! Beaten Verstappen and Bottas. Ferrari: Sainz is 7th";s:4:"link";s:104:"https://wikileaksisdemocracy.org/qatar-hamiltons-pole-beaten-verstappen-and-bottas-ferrari-sainz-is-7th/";s:2:"dc";a:1:{s:7:"creator";s:8:"Tim Hall";}s:7:"pubdate";s:31:"Sat, 20 Nov 2021 22:55:12 +0000";s:8:"category";s:60:"Sport7thBeatenBottasFerrariHamiltonspoleQatarSainzVerstappen";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3566";s:11:"description";s:665:"In qualifying at Losail, the best time of the Mercedes world champion ahead of the Dutch Red Bull and the Finnish. Fourth Gasly who punctures in the final Mercedes and Lewis Hamilton unleashed in Qatar. The magical moment continues for the Englishman who took pole number 102 of his career in Losail and tomorrow will ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4278:"
In qualifying at Losail, the best time of the Mercedes world champion ahead of the Dutch Red Bull and the Finnish. Fourth Gasly who punctures in the final
Mercedes and Lewis Hamilton unleashed in Qatar. The magical moment continues for the Englishman who took pole number 102 of his career in Losail and tomorrow will start ahead of Max Verstappen, second with the Red Bull appearing less fast than the W12. The Dutchman put behind the other Mercedes of Valtteri Bottas, which however can be a factor in tomorrow’s GP, given that Verstappen will not be able to count on the close support of Sergio Perez, who was unexpectedly eliminated in Q2. Fourth time for Pierre Gasly, who punctured in the final and caused a yellow flag on the checkered flag and in fact froze everyone’s times.
The yellow of the double yellow
?
However, it is not certain that this session does not have an extra-track queue, because Verstappen was still very fast under the double yellow flag, with Gasly proceeding slowly on the finish straight: yellow flags on the left and green light (free track) to the right on the straight, a rather confusing situation which could lead to an investigation into the Dutchman anyway. And we already know that Red Bull has asked for new checks on the rear wing of the Mercedes. In short, in such a tight season finale, surprises are always to be taken into account.
So are Q1 and Q2
?
Q1 was very tight, with Hamilton’s best time ahead of Verstappen by 95 thousandths, Bottas and Sainz’s Ferrari. Then Perez, Alonso, Tsunoda and Gasly. The two Alfa Romeos of Kimi Raikkonen and Antonio Giovinazzi, the Williams of Nicholas Latifi and the two Haas of Mick Schumacher and Nikita Mazepin did not pass the cut. In Q2 bad news for Ferrari, which lost Leclerc eliminated with the 13th fastest time: the chassis of the Monegasque must be replaced, which was probably due to a passage on the curbs in Q1. The Cavallino was saved with Carlos Sainz, who managed to qualify for Q3 with the tenth time, the last useful. A small miracle if we consider that Sergio Perez with Red Bull (11th) and Daniel Ricciardo with McLaren (14th) also ended up among the excluded. Also eliminated Lance Stroll (12th) and George Russell (15th).
";}s:7:"summary";s:665:"In qualifying at Losail, the best time of the Mercedes world champion ahead of the Dutch Red Bull and the Finnish. Fourth Gasly who punctures in the final Mercedes and Lewis Hamilton unleashed in Qatar. The magical moment continues for the Englishman who took pole number 102 of his career in Losail and tomorrow will ... Read more";s:12:"atom_content";s:4278:"
In qualifying at Losail, the best time of the Mercedes world champion ahead of the Dutch Red Bull and the Finnish. Fourth Gasly who punctures in the final
Mercedes and Lewis Hamilton unleashed in Qatar. The magical moment continues for the Englishman who took pole number 102 of his career in Losail and tomorrow will start ahead of Max Verstappen, second with the Red Bull appearing less fast than the W12. The Dutchman put behind the other Mercedes of Valtteri Bottas, which however can be a factor in tomorrow’s GP, given that Verstappen will not be able to count on the close support of Sergio Perez, who was unexpectedly eliminated in Q2. Fourth time for Pierre Gasly, who punctured in the final and caused a yellow flag on the checkered flag and in fact froze everyone’s times.
The yellow of the double yellow
?
However, it is not certain that this session does not have an extra-track queue, because Verstappen was still very fast under the double yellow flag, with Gasly proceeding slowly on the finish straight: yellow flags on the left and green light (free track) to the right on the straight, a rather confusing situation which could lead to an investigation into the Dutchman anyway. And we already know that Red Bull has asked for new checks on the rear wing of the Mercedes. In short, in such a tight season finale, surprises are always to be taken into account.
So are Q1 and Q2
?
Q1 was very tight, with Hamilton’s best time ahead of Verstappen by 95 thousandths, Bottas and Sainz’s Ferrari. Then Perez, Alonso, Tsunoda and Gasly. The two Alfa Romeos of Kimi Raikkonen and Antonio Giovinazzi, the Williams of Nicholas Latifi and the two Haas of Mick Schumacher and Nikita Mazepin did not pass the cut. In Q2 bad news for Ferrari, which lost Leclerc eliminated with the 13th fastest time: the chassis of the Monegasque must be replaced, which was probably due to a passage on the curbs in Q1. The Cavallino was saved with Carlos Sainz, who managed to qualify for Q3 with the tenth time, the last useful. A small miracle if we consider that Sergio Perez with Red Bull (11th) and Daniel Ricciardo with McLaren (14th) also ended up among the excluded. Also eliminated Lance Stroll (12th) and George Russell (15th).
";s:14:"date_timestamp";i:1637448912;}i:7;a:11:{s:5:"title";s:67:"Valeria Marini to Verissimo: ?I risked losing my eye, I was afraid?";s:4:"link";s:97:"https://wikileaksisdemocracy.org/valeria-marini-to-verissimo-i-risked-losing-my-eye-i-was-afraid/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Center";}s:7:"pubdate";s:31:"Sat, 20 Nov 2021 22:45:10 +0000";s:8:"category";s:48:"ShowsafraideyelosingMariniriskedValeriaVerissimo";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3562";s:11:"description";s:637:"Valeria Marini guest a very true tells what happened to her in the last few months talking about the severe eye disease for which it is due operate urgently. The showgirl explains what happened to her and how she gets upthe pathology led her to re-evaluate many things in her life. Read also> Nicola Pisu ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4264:"
Valeria Marini guest a very true tells what happened to her in the last few months talking about the severe eye disease for which it is due operate urgently. The showgirl explains what happened to her and how she gets upthe pathology led her to re-evaluate many things in her life.
Read also> Nicola Pisu against Miriana to Verissimo: “It made me feel bad”
Valeria tells Silvia toffanin his ordeal “I had a fairly severe macular hole, I risked losing my left eye and I was very afraid, first because I am very apprehensive and then because I had several checkups and I did well because the surgeon urgently operated on the Sant’Eugenio. The surgery lasted two hours, it was an anomalous situation, but luckily everything seems to have gone well ».
Read also> Gene Gnocchi to Verissimo: “With Covid I lost dear friends, but this hasn’t stopped me from wanting to laugh and make people laugh”
When Silvia Toffanin he asks her how she noticed that something was wrong she explains: “When I left Superviventes, the doctor found a small thing in my eye and told me to let the ophthalmologist see me when I returned to Italy and my doctor told me it was serious and I had to operate. Even there at the beginning I tried to escape the problem but day after day I saw worse and I took courage and I have an operation.“. However, the path to recovery is long and it will not be easy: “Keeping my eye covered makes me feel better because I have to exercise my eyesight. Now I have a glass lens and I have to do some exercises. Getting back to normal will depend on me, from exercises to rehabilitation“. This experience made a mark Valeria who admits that it hasn’t been an easy time, but has always faced everything with optimism.
Then the showgirl talks about her participation in Superviventese, explaining that she was very well received by Spanish TV: “I enjoyed it a lot, even if it cost me the eye, but it was a good experience“. Even earlier he had made the Isola dei Famosi in Italy, Toffanin recalls: “Yes but it’s different, at Superviventes I was the Italian star and I was always nominated, but for me it was a way to disconnect from the tense situation I was experiencing, but I repeat it was a good experience».
There was no lack of memory of Rossano Rubicondi: «I was very sorry, we felt when he came to Italy, we loved each other very much and to know of his death in such a sudden way I was really very sorry».
When Silvia asks her about love: “I’m single, but I’m recovering. I am scared of love, I am always looking for it but in the end I am disappointed. I admit to having had many disappointments, but I don’t stop believing in love. I don’t lack suitors, but I’m scared precisely because I’m fragile and I’m afraid of being disappointed. I honestly think I deserve it, I have always given a lot of love, I like to give lightness and happiness».
";}s:7:"summary";s:637:"Valeria Marini guest a very true tells what happened to her in the last few months talking about the severe eye disease for which it is due operate urgently. The showgirl explains what happened to her and how she gets upthe pathology led her to re-evaluate many things in her life. Read also> Nicola Pisu ... Read more";s:12:"atom_content";s:4264:"
Valeria Marini guest a very true tells what happened to her in the last few months talking about the severe eye disease for which it is due operate urgently. The showgirl explains what happened to her and how she gets upthe pathology led her to re-evaluate many things in her life.
Read also> Nicola Pisu against Miriana to Verissimo: “It made me feel bad”
Valeria tells Silvia toffanin his ordeal “I had a fairly severe macular hole, I risked losing my left eye and I was very afraid, first because I am very apprehensive and then because I had several checkups and I did well because the surgeon urgently operated on the Sant’Eugenio. The surgery lasted two hours, it was an anomalous situation, but luckily everything seems to have gone well ».
Read also> Gene Gnocchi to Verissimo: “With Covid I lost dear friends, but this hasn’t stopped me from wanting to laugh and make people laugh”
When Silvia Toffanin he asks her how she noticed that something was wrong she explains: “When I left Superviventes, the doctor found a small thing in my eye and told me to let the ophthalmologist see me when I returned to Italy and my doctor told me it was serious and I had to operate. Even there at the beginning I tried to escape the problem but day after day I saw worse and I took courage and I have an operation.“. However, the path to recovery is long and it will not be easy: “Keeping my eye covered makes me feel better because I have to exercise my eyesight. Now I have a glass lens and I have to do some exercises. Getting back to normal will depend on me, from exercises to rehabilitation“. This experience made a mark Valeria who admits that it hasn’t been an easy time, but has always faced everything with optimism.
Then the showgirl talks about her participation in Superviventese, explaining that she was very well received by Spanish TV: “I enjoyed it a lot, even if it cost me the eye, but it was a good experience“. Even earlier he had made the Isola dei Famosi in Italy, Toffanin recalls: “Yes but it’s different, at Superviventes I was the Italian star and I was always nominated, but for me it was a way to disconnect from the tense situation I was experiencing, but I repeat it was a good experience».
There was no lack of memory of Rossano Rubicondi: «I was very sorry, we felt when he came to Italy, we loved each other very much and to know of his death in such a sudden way I was really very sorry».
When Silvia asks her about love: “I’m single, but I’m recovering. I am scared of love, I am always looking for it but in the end I am disappointed. I admit to having had many disappointments, but I don’t stop believing in love. I don’t lack suitors, but I’m scared precisely because I’m fragile and I’m afraid of being disappointed. I honestly think I deserve it, I have always given a lot of love, I like to give lightness and happiness».
";s:14:"date_timestamp";i:1637448310;}i:8;a:11:{s:5:"title";s:51:"Role of psychotherapists in treatment effectiveness";s:4:"link";s:85:"https://wikileaksisdemocracy.org/role-of-psychotherapists-in-treatment-effectiveness/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 20 Nov 2021 22:19:17 +0000";s:8:"category";s:60:"Health And ScienceeffectivenesspsychotherapistsroleTreatment";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3557";s:11:"description";s:695:"Journal Reference: Alice E. Coyne, Michael J. Constantino, James F. Boswell, David R. Kraus. Therapist-level moderation of within- and between-therapist process?outcome associations.. Journal of Consulting and Clinical Psychology, 2021; DOI: 10.1037/ccp0000676 The findings, published in the Journal of Consulting and Clinical Psychology, ultimately may lead to more personalized clinical practices and trainings for therapists to ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4535:"
Journal Reference:
Alice E. Coyne, Michael J. Constantino, James F. Boswell, David R. Kraus. Therapist-level moderation of within- and between-therapist process?outcome associations.. Journal of Consulting and Clinical Psychology, 2021; DOI: 10.1037/ccp0000676
The findings, published in the Journal of Consulting and Clinical Psychology, ultimately may lead to more personalized clinical practices and trainings for therapists to help maximize their therapeutic impact and improve patient outcomes.
?Research has tended to focus on the contributions of the patient or treatment type to therapy outcomes, which makes sense in a lot of ways, but unfortunately the therapist contribution has been somewhat neglected,? says lead author Alice Coyne, now a post-doctoral researcher at Case Western Reserve University and a Ph.D. graduate of UMass Amherst. ?Our current trainings, which are often standardized across therapists, tend not to promote consistent improvements in patient outcomes. Instead, we believe that personalizing training to therapists? unique strengths and weaknesses could enhance training outcomes down the line.?
Working with co-author Michael Constantino, professor of clinical psychology and director of the Psychotherapy Research Lab at UMass Amherst, Coyne initially conducted the research as part of her Ph.D. dissertation, which received the 2020 dissertation award from the Society for the Exploration of Psychotherapy Integration.
?Her work is the first of its kind, and it will blaze a trail in our field,? Constantino predicts.
As her dissertation?s first aim, Coyne was interested in testing the prediction that patients experience more symptomatic and functional improvement in psychotherapy when a higher-quality patient-therapist alliance exists, as well as when the patient has a more positive expectation for change.
For the second aim, Coyne was interested in seeing if these associations differed based on who the therapist is. ?A given technique in the hands of one therapist may look very different than that same technique in the hands of another therapist,? Coyne says. ?To put it simply, one therapist may use their relationship with their patients as a key means to facilitate improvement; whereas for another therapist, their relationships with patients may be less important for patient improvement than their use of other strategies, such as cultivating positive expectations for change.?
Finally, for the third aim, Coyne looked at whether certain therapist characteristics predict which therapists tend to use relationship and belief processes to more therapeutic benefit across their caseloads.
To test these questions, the researchers analyzed data from 212 adults who were treated by 42 psychotherapists as part of a randomized trial that compared case-assignment methods in community-based mental health care. Throughout treatment, which varied in length and type, patients repeatedly completed surveys that measured their alliance quality with the therapist and their expectations for improvement.
Coyne and Constantino correctly hypothesized that, in general, better alliance quality and more positive outcome expectation associated with better treatment outcomes. Also, as predicted, therapists exhibited different strengths and weaknesses in their use of relationship and belief processes.
Finally, there was preliminary support that the therapists who used the alliance most effectively to promote patient improvement are the ones ?? who are humbler in assessing their own alliance-fostering abilities,? the paper states.
Humbly know thyself may be one helpful takeaway from the research. ?If you learn the things that you do particularly well as a therapist, then you can tailor your practice and play to your strengths,? Coyne says.
We wish to thank the author of this short article for this outstanding material
";}s:7:"summary";s:695:"Journal Reference: Alice E. Coyne, Michael J. Constantino, James F. Boswell, David R. Kraus. Therapist-level moderation of within- and between-therapist process?outcome associations.. Journal of Consulting and Clinical Psychology, 2021; DOI: 10.1037/ccp0000676 The findings, published in the Journal of Consulting and Clinical Psychology, ultimately may lead to more personalized clinical practices and trainings for therapists to ... Read more";s:12:"atom_content";s:4535:"
Journal Reference:
Alice E. Coyne, Michael J. Constantino, James F. Boswell, David R. Kraus. Therapist-level moderation of within- and between-therapist process?outcome associations.. Journal of Consulting and Clinical Psychology, 2021; DOI: 10.1037/ccp0000676
The findings, published in the Journal of Consulting and Clinical Psychology, ultimately may lead to more personalized clinical practices and trainings for therapists to help maximize their therapeutic impact and improve patient outcomes.
?Research has tended to focus on the contributions of the patient or treatment type to therapy outcomes, which makes sense in a lot of ways, but unfortunately the therapist contribution has been somewhat neglected,? says lead author Alice Coyne, now a post-doctoral researcher at Case Western Reserve University and a Ph.D. graduate of UMass Amherst. ?Our current trainings, which are often standardized across therapists, tend not to promote consistent improvements in patient outcomes. Instead, we believe that personalizing training to therapists? unique strengths and weaknesses could enhance training outcomes down the line.?
Working with co-author Michael Constantino, professor of clinical psychology and director of the Psychotherapy Research Lab at UMass Amherst, Coyne initially conducted the research as part of her Ph.D. dissertation, which received the 2020 dissertation award from the Society for the Exploration of Psychotherapy Integration.
?Her work is the first of its kind, and it will blaze a trail in our field,? Constantino predicts.
As her dissertation?s first aim, Coyne was interested in testing the prediction that patients experience more symptomatic and functional improvement in psychotherapy when a higher-quality patient-therapist alliance exists, as well as when the patient has a more positive expectation for change.
For the second aim, Coyne was interested in seeing if these associations differed based on who the therapist is. ?A given technique in the hands of one therapist may look very different than that same technique in the hands of another therapist,? Coyne says. ?To put it simply, one therapist may use their relationship with their patients as a key means to facilitate improvement; whereas for another therapist, their relationships with patients may be less important for patient improvement than their use of other strategies, such as cultivating positive expectations for change.?
Finally, for the third aim, Coyne looked at whether certain therapist characteristics predict which therapists tend to use relationship and belief processes to more therapeutic benefit across their caseloads.
To test these questions, the researchers analyzed data from 212 adults who were treated by 42 psychotherapists as part of a randomized trial that compared case-assignment methods in community-based mental health care. Throughout treatment, which varied in length and type, patients repeatedly completed surveys that measured their alliance quality with the therapist and their expectations for improvement.
Coyne and Constantino correctly hypothesized that, in general, better alliance quality and more positive outcome expectation associated with better treatment outcomes. Also, as predicted, therapists exhibited different strengths and weaknesses in their use of relationship and belief processes.
Finally, there was preliminary support that the therapists who used the alliance most effectively to promote patient improvement are the ones ?? who are humbler in assessing their own alliance-fostering abilities,? the paper states.
Humbly know thyself may be one helpful takeaway from the research. ?If you learn the things that you do particularly well as a therapist, then you can tailor your practice and play to your strengths,? Coyne says.
We wish to thank the author of this short article for this outstanding material
";s:14:"date_timestamp";i:1637446757;}i:9;a:11:{s:5:"title";s:80:"Study challenges standard ideas about piezoelectricity in ferroelectric crystals";s:4:"link";s:114:"https://wikileaksisdemocracy.org/study-challenges-standard-ideas-about-piezoelectricity-in-ferroelectric-crystals/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 20 Nov 2021 21:02:06 +0000";s:8:"category";s:83:"Health And Sciencechallengescrystalsferroelectricideaspiezoelectricitystandardstudy";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=3552";s:11:"description";s:769:"Journal Reference: Bo Wang, Fei Li, Long?Qing Chen. Inverse Domain?Size Dependence of Piezoelectricity in Ferroelectric Crystals. Advanced Materials, 2021; 2105071 DOI: 10.1002/adma.202105071 Ferroelectric materials possess spontaneous electric dipole moments that can be reversibly flipped by applying an electric field. Domains are areas in the ferroelectric crystal that have the dipole moments aligned in the same ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5293:"
Journal Reference:
Bo Wang, Fei Li, Long?Qing Chen. Inverse Domain?Size Dependence of Piezoelectricity in Ferroelectric Crystals. Advanced Materials, 2021; 2105071 DOI: 10.1002/adma.202105071
Ferroelectric materials possess spontaneous electric dipole moments that can be reversibly flipped by applying an electric field. Domains are areas in the ferroelectric crystal that have the dipole moments aligned in the same direction. Piezoelectricity is a material property where the crystal generates electrical charge under an applied mechanical force. This capability enables piezoelectrics to be used in electronics, sensors and actuators.
?So many devices in our daily life utilize the ability of a material to convert electrical signals to mechanical signals and vice versa,? said Bo Wang, postdoctoral scholar in materials science and engineering. ?In most of these applications, the piezoelectric material plays a key role. And the most advanced piezoelectric materials are the ferroelectric materials.?
At a microscopic scale, ferroelectric materials consist of many domains, and these domains range in size from a few nanometers to as much as millimeters. Each domain consists of uniform or nearly uniform distribution of dipole moments, which occur when there is a separation of charge. The regions between adjacent domains are known as domain walls.
?The domain walls in ferroelectric crystals are interfaces with a very small thickness over which the dipole moments change their directions. It?s well known in the research community of ferroelectric materials that these domain walls have a strong influence on piezoelectricity,? Wang said. ?There is a general belief in the community that the smaller the domain size or higher the domain wall density, the larger the piezoelectric coefficient.?
However, the recent work by Wang and his co-workers, published in Advanced Materials, challenges this conventional wisdom.
?Our theory and computation demonstrated that such a conventional view is actually not often correct,? Wang said.
The researchers found that the idea that smaller domains lead to higher piezoelectricity is based on very limited existing data without a solid theoretical foundation.
?Based on this conventional wisdom, many in the research community have tried to find ways to make all these domains smaller to enhance the piezoelectricity, and often when they see some improvement in the piezoelectric performance, one of the first things that comes to mind is maybe due to the smaller domains,? said Long-Qing Chen, Hamer Professor of Materials Science and Engineering, professor of engineering science and mechanics, and professor of mathematics at Penn State. ?Our work provides a theoretical foundation for correlating the piezoelectricity to crystal symmetry, crystal orientation, and domain configuration.?
In that paper, they referred to findings by other researchers that an AC electric field can improve the piezoelectric response of the crystal by 20% to 40% compared with the crystal treated by a DC electric field. But the team discovered that inside the crystal during AC switching cycles, the domain sizes actually got bigger, not smaller as would be expected.
?We proposed a theoretical model of domain change under electric fields, we use computation to confirm it, and because of our simulation, we have shown that researchers in the future will have to look inside the crystal,? Chen said. ?The previous researchers showed that higher piezoelectric response is due to smaller domains, but they only looked at the surface. We showed computationally that actually, the domains became bigger with higher piezoelectricity, and that was found by examining under the crystal?s surface.?
According to Wang, this new understanding of the relationship between ferroelectric crystal domain size and piezoelectricity can provide guidance to improve piezoelectric performance of materials.
?We hope that this study allows people to rethink the design principles for piezoelectric materials, perhaps creating better piezoelectric materials in ways that were not thought possible before,? Wang said. ?This may enable better piezoelectrics made from lower-cost materials, or from materials that are more environmentally friendly.?
Along with Wang and Chen, the other author on the study was Fei Li, a previous postdoctoral researcher in materials science and engineering at Penn State and now a full professor at Xi?an Jiaotong University in China.
The National Science Foundation supported this research.
We want to give thanks to the author of this short article for this outstanding material
";}s:7:"summary";s:769:"Journal Reference: Bo Wang, Fei Li, Long?Qing Chen. Inverse Domain?Size Dependence of Piezoelectricity in Ferroelectric Crystals. Advanced Materials, 2021; 2105071 DOI: 10.1002/adma.202105071 Ferroelectric materials possess spontaneous electric dipole moments that can be reversibly flipped by applying an electric field. Domains are areas in the ferroelectric crystal that have the dipole moments aligned in the same ... Read more";s:12:"atom_content";s:5293:"
Journal Reference:
Bo Wang, Fei Li, Long?Qing Chen. Inverse Domain?Size Dependence of Piezoelectricity in Ferroelectric Crystals. Advanced Materials, 2021; 2105071 DOI: 10.1002/adma.202105071
Ferroelectric materials possess spontaneous electric dipole moments that can be reversibly flipped by applying an electric field. Domains are areas in the ferroelectric crystal that have the dipole moments aligned in the same direction. Piezoelectricity is a material property where the crystal generates electrical charge under an applied mechanical force. This capability enables piezoelectrics to be used in electronics, sensors and actuators.
?So many devices in our daily life utilize the ability of a material to convert electrical signals to mechanical signals and vice versa,? said Bo Wang, postdoctoral scholar in materials science and engineering. ?In most of these applications, the piezoelectric material plays a key role. And the most advanced piezoelectric materials are the ferroelectric materials.?
At a microscopic scale, ferroelectric materials consist of many domains, and these domains range in size from a few nanometers to as much as millimeters. Each domain consists of uniform or nearly uniform distribution of dipole moments, which occur when there is a separation of charge. The regions between adjacent domains are known as domain walls.
?The domain walls in ferroelectric crystals are interfaces with a very small thickness over which the dipole moments change their directions. It?s well known in the research community of ferroelectric materials that these domain walls have a strong influence on piezoelectricity,? Wang said. ?There is a general belief in the community that the smaller the domain size or higher the domain wall density, the larger the piezoelectric coefficient.?
However, the recent work by Wang and his co-workers, published in Advanced Materials, challenges this conventional wisdom.
?Our theory and computation demonstrated that such a conventional view is actually not often correct,? Wang said.
The researchers found that the idea that smaller domains lead to higher piezoelectricity is based on very limited existing data without a solid theoretical foundation.
?Based on this conventional wisdom, many in the research community have tried to find ways to make all these domains smaller to enhance the piezoelectricity, and often when they see some improvement in the piezoelectric performance, one of the first things that comes to mind is maybe due to the smaller domains,? said Long-Qing Chen, Hamer Professor of Materials Science and Engineering, professor of engineering science and mechanics, and professor of mathematics at Penn State. ?Our work provides a theoretical foundation for correlating the piezoelectricity to crystal symmetry, crystal orientation, and domain configuration.?
In that paper, they referred to findings by other researchers that an AC electric field can improve the piezoelectric response of the crystal by 20% to 40% compared with the crystal treated by a DC electric field. But the team discovered that inside the crystal during AC switching cycles, the domain sizes actually got bigger, not smaller as would be expected.
?We proposed a theoretical model of domain change under electric fields, we use computation to confirm it, and because of our simulation, we have shown that researchers in the future will have to look inside the crystal,? Chen said. ?The previous researchers showed that higher piezoelectric response is due to smaller domains, but they only looked at the surface. We showed computationally that actually, the domains became bigger with higher piezoelectricity, and that was found by examining under the crystal?s surface.?
According to Wang, this new understanding of the relationship between ferroelectric crystal domain size and piezoelectricity can provide guidance to improve piezoelectric performance of materials.
?We hope that this study allows people to rethink the design principles for piezoelectric materials, perhaps creating better piezoelectric materials in ways that were not thought possible before,? Wang said. ?This may enable better piezoelectrics made from lower-cost materials, or from materials that are more environmentally friendly.?
Along with Wang and Chen, the other author on the study was Fei Li, a previous postdoctoral researcher in materials science and engineering at Penn State and now a full professor at Xi?an Jiaotong University in China.
The National Science Foundation supported this research.
We want to give thanks to the author of this short article for this outstanding material