O:9:"MagpieRSS":24:{s:6:"parser";i:0;s:12:"current_item";a:0:{}s:5:"items";a:10:{i:0;a:11:{s:5:"title";s:68:"Corona ?dead vaccine? Novavax: Vaccination skeptics face bitter news";s:4:"link";s:90:"http://happynewbaby.com/corona-dead-vaccine-novavax-vaccination-skeptics-face-bitter-news/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 02:56:18 +0000";s:8:"category";s:61:"NewsbitterCoronadeadfacenewsNovavaxskepticsvaccinationvaccine";s:4:"guid";s:32:"http://happynewbaby.com/?p=15164";s:11:"description";s:674:"Home page world Created: December 24th, 2021, 7:22 pm From: Johannes Nuß divide The inactivated vaccine Novavax against the coronavirus could soon receive approval in the EU and Germany. But there are serious problems with the US authorities. Update from December 20th: The European Medicines Agency (EMA) today recommended the approval of Novavax’s vaccine. After ... Read more";s:7:"content";a:1:{s:7:"encoded";s:13804:"
The inactivated vaccine Novavax against the coronavirus could soon receive approval in the EU and Germany. But there are serious problems with the US authorities.
Update from December 20th: The European Medicines Agency (EMA) today recommended the approval of Novavax’s vaccine. After approval by the EU Commission, it will be the fifth vaccine to be approved in the EU.
Update from December 13th: Is it going much faster than expected? The so-called corona dead vaccine Nuraxovid from Novavax could be recommended for approval by the European Medicines Agency (EMA) before the turn of the year. That was loud Pharmaceutical newspaper (PZ) the director of vaccination strategy, Dr. Marco Cavaleri, known.
Approval could take place this year, he said. With the corona vaccine, which is one of the protein vaccines, five vaccines would so far be available in the European Union (EU) and in Germany. The manufacturer from the USA applied for approval in the EU on November 17th. But: The EMA has been checking preclinical and clinical data on the vaccine in a so-called rolling review process since February, reports Pharmaceutical Newspaper further.
Corona dead vaccines: The vaccine Nuraxovid from Novavax is about to be approved in the EU
The Paul Ehrlich Institute, as the Federal Institute for Vaccines and Biomedical Medicines, describes such a ?rolling review? as follows: Vaccine candidate is started before all the necessary data for a marketing authorization application have been collected. The formal application for approval can be submitted as soon as all the necessary data are available. “
In contrast to the Novavax vaccine, the products from Biontech / Pfizer and Moderna are mRNA vaccines and the vaccines from Astra-Zeneca and Janssen (Johnson & Johnson) are so-called vector vaccines. The weekly magazine TIME recently explained in a simplified manner. In the case of classic live vaccines, for example, live pathogens are used, “whose disease-causing effects have been bred away in the laboratory, so to speak”. It is then a matter of “pathogens that have been rendered harmless”. In the case of dead vaccines, on the other hand, ?only? structures, for example proteins from the pathogen surface, are used that are loud TIME recognized by antibodies and cells of the immune system. Sometimes pathogens are bred and then killed so that they can be administered as a whole ?dead? virus. Then there is a so-called dead vaccine.
An alleged dead vaccine is about to be approved in the EU: the corona vaccine from Novavax. But is the vaccine really a dead vaccine?
First report: Gaithersburg – The corona virus is keeping Germany and the rest of the world in suspense. The vaccination campaign is in full swing, but the second vaccinations are not really making any headway. Up until now, 71.1 percent of the population in Lower Saxony had been vaccinated twice; 21.2 percent of the population received a booster vaccination by Saturday afternoon, December 11, 2021. This still seems too little for the much-cited herd immunity.
US pharmaceutical companies:
Novavax
Founding:
1987
Headquarters:
Gaithersburg, Maryland
Management:
Stanley C. Erck, managing director
Employees:
791
Sales volume:
$ 476 million (FY 2020)
Inactivated vaccine Novavax: solution for vaccine skeptics – vaccine approval is difficult
The problem is vaccination skeptics and opponents. Many of them wanted to rely on the dead vaccine from the US manufacturer Novavax, but there are now problems with the approval of the vaccine. The manufacturer is working feverishly on a solution to the existing problem. Without a solution, approval could be long delayed and the pandemic could spiral out of control. Lower Saxony’s Prime Minister Stephan Weil (SPD) has already declared warning level 3 for his state over Christmas. There were currently more than 500 corona deaths across Germany on Saturday, December 11, 2021. The situation is extremely critical.
Corona inactivated vaccine Novavax: conventional vaccine could change opinion against vaccination opponents
In Lower Saxony, the corona regulations have just been tightened due to the Omikron variant of the corona virus and delta. Even over Christmas and New Year, stricter corona rules should determine social interaction in Lower Saxony. And the 2G rule that has been introduced in retail is also making it more and more difficult for unvaccinated people, when the news that there are problems with the approval of the inactivated vaccine from Novavax comes at an inopportune time.
Because many of the lateral thinkers, corona opponents, vaccination opponents or vaccination skeptics had hidden behind the statement that they only wanted to be vaccinated with the dead vaccine. The fact that these people can hardly be dealt with with facts and conclusive arguments is shown again and again in discussions. Therefore, many hope that the dead vaccine Novavax could be the savior.
Novavax corona vaccine: dead vaccine the panacea for opponents of vector or mRNA vaccines such as Biontech or Moderna
Because the Novavax corona vaccine is a so-called dead vaccine, the principle of which is also used in many other vaccinations. Opponents of the mRNA vaccines or vector vaccines, such as those from Biontech or Moderna, claim that these are much more researched.
As a result, many people who oppose these vaccines are more open to an inactivated vaccine. The fact that the inactivated vaccine Novavax, unlike Biontech’s vaccine, can be stored in the refrigerator, had nourished hopes that it would be able to supply poorer countries with it.
Corona inactivated vaccine Novavax is 90 percent effective and provides 100 percent protection against moderate or severe disease
For example, Indonesia approved the vaccine in the summer, followed shortly after by the island nation of the Philippines in Southeast Asia. Applications have been made for approval at the European Medicines Agency of the European Union, EMA, since mid-November. According to the manufacturer, the Novavax inactivated corona vaccine should be 90 percent effective and protect 100 percent against moderate and severe disease. The EU Commission had already ordered 100 million doses of the vaccine in August. Further deliveries are to follow in 2021, 2022 and 2023.
But now there are problems with the delivery of the vaccine and that could also threaten or at least delay the approval on the American market by the FDA – which also affects the EU. In addition, quality standards are said to have not been met, reported Forbes magazine in its US edition. The cracks in global supply chains due to the corona pandemic and the acute shortage of raw materials are contributing to this.
Delivery problems in the USA threaten the approval of corona vaccine Novavax in the European Union – Corona dead vaccine Novavax actually not a dead vaccine at all
The problem, why the delivery problems threaten the approval of the corona vaccine Novavax and why the EU has to wait further, is that there is a vaccine approval only if the manufacturer can deliver without restrictions. As soon as this has been remedied, according to Novavax boss Stanley C. Erck, the first 100 million cans will be sent to the European Union. As it is said, the company wants to produce at least two billion vaccine doses in 2022 alone. To solve the delivery problem, Novavax recently announced that it would enter into a cooperation with the world’s largest vaccine manufacturer Serum Institut of India.
What is the difference between vector, dead or live and mRNA vaccines?
Vector-based vaccines (e.g. AstraZeneca) consist of viruses that are harmless to humans and that have been genetically modified in such a way that their genome contains the genetic sequence with the blueprint for one or more components of the pathogen (antigen) against which the vaccine is directed. The Covid-19 vector vaccine candidates contain harmless, well-studied carrier viruses, into whose genome a gene has been incorporated that contains the blueprint for the SARS-CoV-2 surface protein, the spike protein.
the Dead or living Covid-19 vaccines do not contain any viruses that can replicate. In this respect, they can be equated with dead vaccines. Such dead vaccines are inactivated; they contain killed pathogens or pathogen components that can neither multiply nor trigger a disease.
mRNA vaccines contain gene segments of the SARS-CoV-2 virus in the form of messenger RNA (mRNA for short), which is also known as messenger RNA. Starting from the mRNA, proteins are produced in body cells after inoculation, which then stimulate the immune system to generate specific antibodies against SARS-CoV-2 and a cellular defense against SARS-CoV-2-infected cells, thus generating an immune reaction. Proteins that stimulate an immune response are called antigens. (Source: Robert Koch Institute)
Although the Novavax vaccine is widely criticized as a dead vaccine, if you take it very seriously, that’s not true. Federal Health Minister Karl Lauterbach (SPD) wrote on Twitter that it is much more about a protein vaccine. Novavax also presents this on its own company website. * kreiszeitung.de and merkur.de are offers from IPPEN.MEDIA.
We would like to thank the author of this article for this awesome content
";}s:7:"summary";s:674:"Home page world Created: December 24th, 2021, 7:22 pm From: Johannes Nuß divide The inactivated vaccine Novavax against the coronavirus could soon receive approval in the EU and Germany. But there are serious problems with the US authorities. Update from December 20th: The European Medicines Agency (EMA) today recommended the approval of Novavax’s vaccine. After ... Read more";s:12:"atom_content";s:13804:"
The inactivated vaccine Novavax against the coronavirus could soon receive approval in the EU and Germany. But there are serious problems with the US authorities.
Update from December 20th: The European Medicines Agency (EMA) today recommended the approval of Novavax’s vaccine. After approval by the EU Commission, it will be the fifth vaccine to be approved in the EU.
Update from December 13th: Is it going much faster than expected? The so-called corona dead vaccine Nuraxovid from Novavax could be recommended for approval by the European Medicines Agency (EMA) before the turn of the year. That was loud Pharmaceutical newspaper (PZ) the director of vaccination strategy, Dr. Marco Cavaleri, known.
Approval could take place this year, he said. With the corona vaccine, which is one of the protein vaccines, five vaccines would so far be available in the European Union (EU) and in Germany. The manufacturer from the USA applied for approval in the EU on November 17th. But: The EMA has been checking preclinical and clinical data on the vaccine in a so-called rolling review process since February, reports Pharmaceutical Newspaper further.
Corona dead vaccines: The vaccine Nuraxovid from Novavax is about to be approved in the EU
The Paul Ehrlich Institute, as the Federal Institute for Vaccines and Biomedical Medicines, describes such a ?rolling review? as follows: Vaccine candidate is started before all the necessary data for a marketing authorization application have been collected. The formal application for approval can be submitted as soon as all the necessary data are available. “
In contrast to the Novavax vaccine, the products from Biontech / Pfizer and Moderna are mRNA vaccines and the vaccines from Astra-Zeneca and Janssen (Johnson & Johnson) are so-called vector vaccines. The weekly magazine TIME recently explained in a simplified manner. In the case of classic live vaccines, for example, live pathogens are used, “whose disease-causing effects have been bred away in the laboratory, so to speak”. It is then a matter of “pathogens that have been rendered harmless”. In the case of dead vaccines, on the other hand, ?only? structures, for example proteins from the pathogen surface, are used that are loud TIME recognized by antibodies and cells of the immune system. Sometimes pathogens are bred and then killed so that they can be administered as a whole ?dead? virus. Then there is a so-called dead vaccine.
An alleged dead vaccine is about to be approved in the EU: the corona vaccine from Novavax. But is the vaccine really a dead vaccine?
First report: Gaithersburg – The corona virus is keeping Germany and the rest of the world in suspense. The vaccination campaign is in full swing, but the second vaccinations are not really making any headway. Up until now, 71.1 percent of the population in Lower Saxony had been vaccinated twice; 21.2 percent of the population received a booster vaccination by Saturday afternoon, December 11, 2021. This still seems too little for the much-cited herd immunity.
US pharmaceutical companies:
Novavax
Founding:
1987
Headquarters:
Gaithersburg, Maryland
Management:
Stanley C. Erck, managing director
Employees:
791
Sales volume:
$ 476 million (FY 2020)
Inactivated vaccine Novavax: solution for vaccine skeptics – vaccine approval is difficult
The problem is vaccination skeptics and opponents. Many of them wanted to rely on the dead vaccine from the US manufacturer Novavax, but there are now problems with the approval of the vaccine. The manufacturer is working feverishly on a solution to the existing problem. Without a solution, approval could be long delayed and the pandemic could spiral out of control. Lower Saxony’s Prime Minister Stephan Weil (SPD) has already declared warning level 3 for his state over Christmas. There were currently more than 500 corona deaths across Germany on Saturday, December 11, 2021. The situation is extremely critical.
Corona inactivated vaccine Novavax: conventional vaccine could change opinion against vaccination opponents
In Lower Saxony, the corona regulations have just been tightened due to the Omikron variant of the corona virus and delta. Even over Christmas and New Year, stricter corona rules should determine social interaction in Lower Saxony. And the 2G rule that has been introduced in retail is also making it more and more difficult for unvaccinated people, when the news that there are problems with the approval of the inactivated vaccine from Novavax comes at an inopportune time.
Because many of the lateral thinkers, corona opponents, vaccination opponents or vaccination skeptics had hidden behind the statement that they only wanted to be vaccinated with the dead vaccine. The fact that these people can hardly be dealt with with facts and conclusive arguments is shown again and again in discussions. Therefore, many hope that the dead vaccine Novavax could be the savior.
Novavax corona vaccine: dead vaccine the panacea for opponents of vector or mRNA vaccines such as Biontech or Moderna
Because the Novavax corona vaccine is a so-called dead vaccine, the principle of which is also used in many other vaccinations. Opponents of the mRNA vaccines or vector vaccines, such as those from Biontech or Moderna, claim that these are much more researched.
As a result, many people who oppose these vaccines are more open to an inactivated vaccine. The fact that the inactivated vaccine Novavax, unlike Biontech’s vaccine, can be stored in the refrigerator, had nourished hopes that it would be able to supply poorer countries with it.
Corona inactivated vaccine Novavax is 90 percent effective and provides 100 percent protection against moderate or severe disease
For example, Indonesia approved the vaccine in the summer, followed shortly after by the island nation of the Philippines in Southeast Asia. Applications have been made for approval at the European Medicines Agency of the European Union, EMA, since mid-November. According to the manufacturer, the Novavax inactivated corona vaccine should be 90 percent effective and protect 100 percent against moderate and severe disease. The EU Commission had already ordered 100 million doses of the vaccine in August. Further deliveries are to follow in 2021, 2022 and 2023.
But now there are problems with the delivery of the vaccine and that could also threaten or at least delay the approval on the American market by the FDA – which also affects the EU. In addition, quality standards are said to have not been met, reported Forbes magazine in its US edition. The cracks in global supply chains due to the corona pandemic and the acute shortage of raw materials are contributing to this.
Delivery problems in the USA threaten the approval of corona vaccine Novavax in the European Union – Corona dead vaccine Novavax actually not a dead vaccine at all
The problem, why the delivery problems threaten the approval of the corona vaccine Novavax and why the EU has to wait further, is that there is a vaccine approval only if the manufacturer can deliver without restrictions. As soon as this has been remedied, according to Novavax boss Stanley C. Erck, the first 100 million cans will be sent to the European Union. As it is said, the company wants to produce at least two billion vaccine doses in 2022 alone. To solve the delivery problem, Novavax recently announced that it would enter into a cooperation with the world’s largest vaccine manufacturer Serum Institut of India.
What is the difference between vector, dead or live and mRNA vaccines?
Vector-based vaccines (e.g. AstraZeneca) consist of viruses that are harmless to humans and that have been genetically modified in such a way that their genome contains the genetic sequence with the blueprint for one or more components of the pathogen (antigen) against which the vaccine is directed. The Covid-19 vector vaccine candidates contain harmless, well-studied carrier viruses, into whose genome a gene has been incorporated that contains the blueprint for the SARS-CoV-2 surface protein, the spike protein.
the Dead or living Covid-19 vaccines do not contain any viruses that can replicate. In this respect, they can be equated with dead vaccines. Such dead vaccines are inactivated; they contain killed pathogens or pathogen components that can neither multiply nor trigger a disease.
mRNA vaccines contain gene segments of the SARS-CoV-2 virus in the form of messenger RNA (mRNA for short), which is also known as messenger RNA. Starting from the mRNA, proteins are produced in body cells after inoculation, which then stimulate the immune system to generate specific antibodies against SARS-CoV-2 and a cellular defense against SARS-CoV-2-infected cells, thus generating an immune reaction. Proteins that stimulate an immune response are called antigens. (Source: Robert Koch Institute)
Although the Novavax vaccine is widely criticized as a dead vaccine, if you take it very seriously, that’s not true. Federal Health Minister Karl Lauterbach (SPD) wrote on Twitter that it is much more about a protein vaccine. Novavax also presents this on its own company website. * kreiszeitung.de and merkur.de are offers from IPPEN.MEDIA.
We would like to thank the author of this article for this awesome content
";s:14:"date_timestamp";i:1640400978;}i:1;a:11:{s:5:"title";s:41:"Vegan Potato Salad: Easy and Quick Recipe";s:4:"link";s:65:"http://happynewbaby.com/vegan-potato-salad-easy-and-quick-recipe/";s:2:"dc";a:1:{s:7:"creator";s:15:"Pauline Moonlky";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 02:55:37 +0000";s:8:"category";s:39:"MagazineeasypotatoQuickrecipeSaladvegan";s:4:"guid";s:32:"http://happynewbaby.com/?p=15158";s:11:"description";s:538:"I like to eat potato salad for Christmas or New Year’s Eve. It tastes best to me according to the recipe from Carsten’s mother. As a vegan, I modified it so that it is purely plant-based. Here comes my vegan potato salad, which you can easily prepare. Vegan potato salad with mayonnaise A classic meal ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7217:"
I like to eat potato salad for Christmas or New Year’s Eve. It tastes best to me according to the recipe from Carsten’s mother. As a vegan, I modified it so that it is purely plant-based. Here comes my vegan potato salad, which you can easily prepare.
Vegan potato salad with mayonnaise
A classic meal at Christmas time is potato salad. But what comes in? Opinions are already divided when it comes to mayo or vinegar and oil as a dressing.
Do you know Silesian potato salad? According to Wikipedia, ?Sza?ot? consists of boiled potato squares, carrots, peas, ham, various sausages, pickled fish, boiled eggs and olive oil or mayonnaise.
Carsten’s mother was born in Opole (Opole), in south-western Poland. Your family recipe has already been modified from the original, I’ve veganized it.
Thanks to pickles and apples, the potato salad tastes sweet, sour and fresh. In the vegan version, the mayo is purely plant-based, there are no eggs and you can add vegan meat sausage. I like to eat soy sausages or sausages with pea protein with potato salad.
Delicious food for Christmas or New Years Eve
Incidentally, the hearty recipe is not just for a festive lunch or dinner in winter. The salad also tastes very good as a side dish in summer for grilling.
In the Advent season, however, I am particularly happy about a simple and quick recipe.
Because you can spend a lot of time with Christmas decorations, buying gifts or baking cookies. Then my beloved Christmas films are still waiting for me and we have another look at the Christmas lights in the Mönchengladbach weavers’ settlement.
Here is the recipe for you.
Vegan potato salad recipe
ingredients
for 4 people
1 kg of waxy potatoes
3 pickles
1 apple
2 small onions
2 cloves of garlic
3 tbsp vinegar
300 g Mayonnaise
If necessary, 200 g vegan meat sausage
salt
Pfeffer
preparation
Cover and cook jacket potatoes in salted water for around 20 to 30 minutes, cooking time depending on the size of the potatoes. Quench with cold water, peel and cut into pieces.
Chop the cucumber, apple and onion and add. Press in the garlic with the garlic press.
Add vinegar, mayonnaise and, if necessary, vegan meat sausage.
Season to taste with salt and pepper.
Let the potato salad soak in the fridge overnight.
By the way: If you’re still looking for a Christmas dessert, then take a look at my baked apple recipe.
Newsletter & Social Media
Would you like to be informed about new blog posts? Then subscribe to Travel on Toast via Newsletter. Once a month you will receive inspiration, insider tips and information on competitions. Also like to follow me about Instagram, Facebook, Pinterest, Tik Tok or YouTube. You can find out more about me here.
Vegan potato salad: Note the recipe on Pinterest
The following two tabs change content below.
This travel blog & food blog is about beach holidays, city trips, road trips, holidays with your dog and vegan food. Feel free to follow me on Facebook, Instagram, Pinterest or YouTube.
We would like to say thanks to the author of this write-up for this incredible content
";}s:7:"summary";s:538:"I like to eat potato salad for Christmas or New Year’s Eve. It tastes best to me according to the recipe from Carsten’s mother. As a vegan, I modified it so that it is purely plant-based. Here comes my vegan potato salad, which you can easily prepare. Vegan potato salad with mayonnaise A classic meal ... Read more";s:12:"atom_content";s:7217:"
I like to eat potato salad for Christmas or New Year’s Eve. It tastes best to me according to the recipe from Carsten’s mother. As a vegan, I modified it so that it is purely plant-based. Here comes my vegan potato salad, which you can easily prepare.
Vegan potato salad with mayonnaise
A classic meal at Christmas time is potato salad. But what comes in? Opinions are already divided when it comes to mayo or vinegar and oil as a dressing.
Do you know Silesian potato salad? According to Wikipedia, ?Sza?ot? consists of boiled potato squares, carrots, peas, ham, various sausages, pickled fish, boiled eggs and olive oil or mayonnaise.
Carsten’s mother was born in Opole (Opole), in south-western Poland. Your family recipe has already been modified from the original, I’ve veganized it.
Thanks to pickles and apples, the potato salad tastes sweet, sour and fresh. In the vegan version, the mayo is purely plant-based, there are no eggs and you can add vegan meat sausage. I like to eat soy sausages or sausages with pea protein with potato salad.
Delicious food for Christmas or New Years Eve
Incidentally, the hearty recipe is not just for a festive lunch or dinner in winter. The salad also tastes very good as a side dish in summer for grilling.
In the Advent season, however, I am particularly happy about a simple and quick recipe.
Because you can spend a lot of time with Christmas decorations, buying gifts or baking cookies. Then my beloved Christmas films are still waiting for me and we have another look at the Christmas lights in the Mönchengladbach weavers’ settlement.
Here is the recipe for you.
Vegan potato salad recipe
ingredients
for 4 people
1 kg of waxy potatoes
3 pickles
1 apple
2 small onions
2 cloves of garlic
3 tbsp vinegar
300 g Mayonnaise
If necessary, 200 g vegan meat sausage
salt
Pfeffer
preparation
Cover and cook jacket potatoes in salted water for around 20 to 30 minutes, cooking time depending on the size of the potatoes. Quench with cold water, peel and cut into pieces.
Chop the cucumber, apple and onion and add. Press in the garlic with the garlic press.
Add vinegar, mayonnaise and, if necessary, vegan meat sausage.
Season to taste with salt and pepper.
Let the potato salad soak in the fridge overnight.
By the way: If you’re still looking for a Christmas dessert, then take a look at my baked apple recipe.
Newsletter & Social Media
Would you like to be informed about new blog posts? Then subscribe to Travel on Toast via Newsletter. Once a month you will receive inspiration, insider tips and information on competitions. Also like to follow me about Instagram, Facebook, Pinterest, Tik Tok or YouTube. You can find out more about me here.
Vegan potato salad: Note the recipe on Pinterest
The following two tabs change content below.
This travel blog & food blog is about beach holidays, city trips, road trips, holidays with your dog and vegan food. Feel free to follow me on Facebook, Instagram, Pinterest or YouTube.
We would like to say thanks to the author of this write-up for this incredible content
";s:14:"date_timestamp";i:1640400937;}i:2;a:11:{s:5:"title";s:78:"?Pop-up? electronic sensors could detect when individual heart cells misbehave";s:4:"link";s:101:"http://happynewbaby.com/pop-up-electronic-sensors-could-detect-when-individual-heart-cells-misbehave/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 02:48:08 +0000";s:8:"category";s:75:"Health And SciencecellsdetectElectronicHEARTindividualmisbehavepopupsensors";s:4:"guid";s:33:"https://happynewbaby.com/?p=15153";s:11:"description";s:687:"Journal Reference: Yue Gu, Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Rohollah Nasiri, Jinfeng Li, Daibo Zhang, Albert Yang, Leo Huan-Hsuan Hsu, Xiaochuan Dai, Jing Mu, Zheyuan Liu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Xingcai Zhang, Samad ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7412:"
Journal Reference:
Yue Gu, Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Rohollah Nasiri, Jinfeng Li, Daibo Zhang, Albert Yang, Leo Huan-Hsuan Hsu, Xiaochuan Dai, Jing Mu, Zheyuan Liu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Xingcai Zhang, Samad Ahadian, Pooja Banik, Liangfang Zhang, Xiaocheng Jiang, Peter J. Burke, Ali Khademhosseini, Andrew D. McCulloch, Sheng Xu. Three-dimensional transistor arrays for intra- and inter-cellular recording. Nature Nanotechnology, 2021; DOI: 10.1038/s41565-021-01040-w
The device, published Dec. 23 in the journal Nature Nanotechnology, could enable scientists to gain more detailed insights into heart disorders and diseases such as arrhythmia (abnormal heart rhythm), heart attack and cardiac fibrosis (stiffening or thickening of heart tissue).
?Studying how an electrical signal propagates between different cells is important to understand the mechanism of cell function and disease,? said first author Yue Gu, who recently received his Ph.D. in materials science and engineering at UC San Diego. ?Irregularities in this signal can be a sign of arrhythmia, for example. If the signal cannot propagate correctly from one part of the heart to another, then some part of the heart cannot receive the signal so it cannot contract.?
?With this device, we can zoom in to the cellular level and get a very high resolution picture of what?s going on in the heart; we can see which cells are malfunctioning, which parts are not synchronized with the others, and pinpoint where the signal is weak,? said senior author Sheng Xu, a professor of nanoengineering at the UC San Diego Jacobs School of Engineering. ?This information could be used to help inform clinicians and enable them to make better diagnoses.?
The device consists of a 3D array of microscopic field effect transistors, or FETs, that are shaped like sharp pointed tips. These tiny FETs pierce through cell membranes without damaging them and are sensitive enough to detect electrical signals ? even very weak ones ? directly inside the cells. To evade being seen as a foreign substance and remain inside the cells for long periods of time, the FETs are coated in a phospholipid bilayer. The FETs can monitor signals from multiple cells at the same time. They can even monitor signals at two different sites inside the same cell.
?That?s what makes this device unique,? said Gu. ?It can have two FET sensors penetrate inside one cell ? with minimal invasiveness ? and allow us to see which way a signal propagates and how fast it goes. This detailed information about signal transportation within a single cell has so far been unknown.?
To build the device, the team first fabricated the FETs as 2D shapes, and then bonded select spots of these shapes onto a pre-stretched elastomer sheet. The researchers then loosened the elastomer sheet, causing the device to buckle and the FETs to fold into a 3D structure so that they can penetrate inside cells.
?It?s like a pop-up book,? said Gu. ?It starts out as a 2D structure, and with compressive force it pops up at some portions and becomes a 3D structure.?
The team tested the device on heart muscle cell cultures and on cardiac tissues that were engineered in the lab. The experiments involved placing either the cell culture or tissue on top of the device and then monitoring the electrical signals that the FET sensors picked up. By seeing which sensors detected a signal first and then measuring the times it took for other sensors to detect the signal, the team could determine which way the signal traveled and its speed. The researchers were able to do this for signals traveling between neighboring cells, and for the first time, for signals traveling within a single heart muscle cell.
What makes this even more exciting, said Xu, is that this is the first time that scientists have been able to measure intracellular signals in 3D tissue constructs. ?So far, only extracellular signals, meaning signals that are outside of the cell membrane, have been measured in these types of tissues. Now, we can actually pick up signals inside the cells that are embedded in the 3D tissue or organoid,? he said.
The team?s experiments led to an interesting observation: signals inside individual heart cells travel almost five times faster than signals between multiple heart cells. Studying these kinds of details could reveal insights on heart abnormalities at the cellular level, said Gu. ?Say you?re measuring the signal speed in one cell, and the signal speed between two cells. If there?s a very big difference between these two speeds ? that is, if the intercellular speed is much, much smaller than the intracellular speed ? then it?s likely that something is wrong at the junction between the cells, possibly due to fibrosis,? he explained.
Biologists could also use this device to study signal transportation between different organelles in a cell, added Gu. A device like this could also be used for testing new drugs and seeing how they affect heart cells and tissues.
The device would also be useful for studying electrical activity inside neurons. This is a direction that the team is looking to explore next. Down the line, the researchers plan to use their device to record electrical activity in real biological tissue in vivo. Xu envisions an implantable device that can be placed on the surface of a beating heart or on the surface of the cortex. But the device is still far from that stage. To get there, the researchers have more work to do including fine-tuning the layout of the FET sensors, optimizing the FET array size and materials, and integrating AI-assisted signal processing algorithms into the device.
Paper: ?Three-dimensional transistor arrays for intra- and inter-cellular recording.? Co-authors include Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Jing Mu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Pooja Banik, Liangfang Zhang and Andrew D. McCulloch, UC San Diego; Rohollah Nasiri, Samad Ahadian and Ali Khademhosseini, Terasaki Institute for Biomedical Innovation; Jinfeng Li and Peter J. Burke, UC Irvine; Leo Huan-Hsuan Hsu, Xiaochuan Dai and Xiaocheng Jiang, Tufts University; Zheyuan Liu, Massachusetts Institute of Technology; and Xingcai Zhang, Harvard University.
This work was supported by the National Institutes of Health (1 R35 GM138250 01).
We would love to give thanks to the writer of this short article for this remarkable material
";}s:7:"summary";s:687:"Journal Reference: Yue Gu, Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Rohollah Nasiri, Jinfeng Li, Daibo Zhang, Albert Yang, Leo Huan-Hsuan Hsu, Xiaochuan Dai, Jing Mu, Zheyuan Liu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Xingcai Zhang, Samad ... Read more";s:12:"atom_content";s:7412:"
Journal Reference:
Yue Gu, Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Rohollah Nasiri, Jinfeng Li, Daibo Zhang, Albert Yang, Leo Huan-Hsuan Hsu, Xiaochuan Dai, Jing Mu, Zheyuan Liu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Xingcai Zhang, Samad Ahadian, Pooja Banik, Liangfang Zhang, Xiaocheng Jiang, Peter J. Burke, Ali Khademhosseini, Andrew D. McCulloch, Sheng Xu. Three-dimensional transistor arrays for intra- and inter-cellular recording. Nature Nanotechnology, 2021; DOI: 10.1038/s41565-021-01040-w
The device, published Dec. 23 in the journal Nature Nanotechnology, could enable scientists to gain more detailed insights into heart disorders and diseases such as arrhythmia (abnormal heart rhythm), heart attack and cardiac fibrosis (stiffening or thickening of heart tissue).
?Studying how an electrical signal propagates between different cells is important to understand the mechanism of cell function and disease,? said first author Yue Gu, who recently received his Ph.D. in materials science and engineering at UC San Diego. ?Irregularities in this signal can be a sign of arrhythmia, for example. If the signal cannot propagate correctly from one part of the heart to another, then some part of the heart cannot receive the signal so it cannot contract.?
?With this device, we can zoom in to the cellular level and get a very high resolution picture of what?s going on in the heart; we can see which cells are malfunctioning, which parts are not synchronized with the others, and pinpoint where the signal is weak,? said senior author Sheng Xu, a professor of nanoengineering at the UC San Diego Jacobs School of Engineering. ?This information could be used to help inform clinicians and enable them to make better diagnoses.?
The device consists of a 3D array of microscopic field effect transistors, or FETs, that are shaped like sharp pointed tips. These tiny FETs pierce through cell membranes without damaging them and are sensitive enough to detect electrical signals ? even very weak ones ? directly inside the cells. To evade being seen as a foreign substance and remain inside the cells for long periods of time, the FETs are coated in a phospholipid bilayer. The FETs can monitor signals from multiple cells at the same time. They can even monitor signals at two different sites inside the same cell.
?That?s what makes this device unique,? said Gu. ?It can have two FET sensors penetrate inside one cell ? with minimal invasiveness ? and allow us to see which way a signal propagates and how fast it goes. This detailed information about signal transportation within a single cell has so far been unknown.?
To build the device, the team first fabricated the FETs as 2D shapes, and then bonded select spots of these shapes onto a pre-stretched elastomer sheet. The researchers then loosened the elastomer sheet, causing the device to buckle and the FETs to fold into a 3D structure so that they can penetrate inside cells.
?It?s like a pop-up book,? said Gu. ?It starts out as a 2D structure, and with compressive force it pops up at some portions and becomes a 3D structure.?
The team tested the device on heart muscle cell cultures and on cardiac tissues that were engineered in the lab. The experiments involved placing either the cell culture or tissue on top of the device and then monitoring the electrical signals that the FET sensors picked up. By seeing which sensors detected a signal first and then measuring the times it took for other sensors to detect the signal, the team could determine which way the signal traveled and its speed. The researchers were able to do this for signals traveling between neighboring cells, and for the first time, for signals traveling within a single heart muscle cell.
What makes this even more exciting, said Xu, is that this is the first time that scientists have been able to measure intracellular signals in 3D tissue constructs. ?So far, only extracellular signals, meaning signals that are outside of the cell membrane, have been measured in these types of tissues. Now, we can actually pick up signals inside the cells that are embedded in the 3D tissue or organoid,? he said.
The team?s experiments led to an interesting observation: signals inside individual heart cells travel almost five times faster than signals between multiple heart cells. Studying these kinds of details could reveal insights on heart abnormalities at the cellular level, said Gu. ?Say you?re measuring the signal speed in one cell, and the signal speed between two cells. If there?s a very big difference between these two speeds ? that is, if the intercellular speed is much, much smaller than the intracellular speed ? then it?s likely that something is wrong at the junction between the cells, possibly due to fibrosis,? he explained.
Biologists could also use this device to study signal transportation between different organelles in a cell, added Gu. A device like this could also be used for testing new drugs and seeing how they affect heart cells and tissues.
The device would also be useful for studying electrical activity inside neurons. This is a direction that the team is looking to explore next. Down the line, the researchers plan to use their device to record electrical activity in real biological tissue in vivo. Xu envisions an implantable device that can be placed on the surface of a beating heart or on the surface of the cortex. But the device is still far from that stage. To get there, the researchers have more work to do including fine-tuning the layout of the FET sensors, optimizing the FET array size and materials, and integrating AI-assisted signal processing algorithms into the device.
Paper: ?Three-dimensional transistor arrays for intra- and inter-cellular recording.? Co-authors include Chunfeng Wang, Namheon Kim, Jingxin Zhang, Tsui Min Wang, Jennifer Stowe, Jing Mu, Muyang Lin, Weixin Li, Chonghe Wang, Hua Gong, Yimu Chen, Yusheng Lei, Hongjie Hu, Yang Li, Lin Zhang, Zhenlong Huang, Pooja Banik, Liangfang Zhang and Andrew D. McCulloch, UC San Diego; Rohollah Nasiri, Samad Ahadian and Ali Khademhosseini, Terasaki Institute for Biomedical Innovation; Jinfeng Li and Peter J. Burke, UC Irvine; Leo Huan-Hsuan Hsu, Xiaochuan Dai and Xiaocheng Jiang, Tufts University; Zheyuan Liu, Massachusetts Institute of Technology; and Xingcai Zhang, Harvard University.
This work was supported by the National Institutes of Health (1 R35 GM138250 01).
We would love to give thanks to the writer of this short article for this remarkable material
";s:14:"date_timestamp";i:1640400488;}i:3;a:11:{s:5:"title";s:48:"Best Christmas Movies & Specials For Sports Fans";s:4:"link";s:71:"http://happynewbaby.com/best-christmas-movies-specials-for-sports-fans/";s:2:"dc";a:1:{s:7:"creator";s:9:"Blue Holt";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 02:35:44 +0000";s:8:"category";s:38:"SportChristmasfansMoviesSpecialsSports";s:4:"guid";s:33:"https://happynewbaby.com/?p=15147";s:11:"description";s:568:"Christmas is just a few days away, which means that Christmas movies and specials are dominating the world of film and television. And while there are classic movies and specials that everyone should see, the real question is, which are the best for sports fans? If there’s one that stands out, it has to be ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5015:"
Christmas is just a few days away, which means that Christmas movies and specials are dominating the world of film and television. And while there are classic movies and specials that everyone should see, the real question is, which are the best for sports fans? If there’s one that stands out, it has to be Rocky IV starring Sylvester Stallone and Dolph Lundgren. It might not be a Christmas movie for the average fan, but Christmas plays a big part in the story.
David Maars of The Daily Squat wrote: ?If your childhood Christmases were like mine, watching two men fight was a frequent occurrence, so nothing puts me in the Christmas spirit like Rocky IV. And whether or not ?Rocky IV? is a Christmas movie that’s not even up for debate. The climactic fight between Rocky Balboa and Ivan Drago takes place on December 25. For the unlit, it’s Christmas Day. ”
Rocky IV is a nontraditional Christmas movie, but there are others on this list that feature WWE Superstars, an iconic hockey team, and a lovable soccer coach. Here’s a look at the best Christmas movies and holiday specials for sports fans.
Holiday special ‘Ted Lasso’
(Photo : Apple TV)
Ted Lasso is a huge hit for Apple TV + because he’s won multiple Emmy Awards. This year, AppleTV + released a five-minute animated special that features the voices of the cast of Ted Lasso, including Jason Sudeikis, Hannah Waddingham, and Brett Goldstein. The special can be seen on AppleTV + or on its YouTube page.
Previous Next
Robbie the Reindeer: Fire Hooves
This animated special follows Robbie, a reindeer looking to join Santa’s sleigh team, just like his father Rudolph. He travels to the North Pole and meets Blitzen, who seeks to “destroy” Robbie.
Previous Next
Santa Claus with muscles
Everyone’s talking about the best Christmas movies? but what about the worst?
Here’s mine: “Santa with Muscles” with Hulk Hogan. pic.twitter.com/QO0uFcoHxk
– Chuck Thomas (@chuckthomasuk) December 22, 2021
As previously mentioned, Santa with Muscles introduces Hulk Hogan, and he plays a self-made billionaire who gets into trouble after playing paintball. He is targeted by the police, which results in him hiding in a shopping mall and wearing a Santa Claus outfit. Hogan’s character bangs his head, causing amnesia and being convinced that he is Santa Claus.
Previous Next
Miracle
It’s not a Christmas movie, but there is a Christmas scene. Miracle is a film based on the United States hockey team shattering Soviet professionals at the 1980 Winter Olympics. The film was well received by critics and grossed $ 64.5 million at the box office .
Previous Next
Rocky IV
Rocky IV is not considered a Christmas movie, but the fight between Rocky and Ivan Drago takes place on Christmas Day. At the end of the fight, Rocky wished his son a Merry Christmas as he celebrated his big win.
Previous Next
Santa’s little helper
WWE’s The Miz starred in the live-action TV movie Santa’s Little Helper and played Dax and a greedy corporate man who gets fired and loses everything. He is then seen again by Bille, an elf from the North Pole, to be Santa’s little helper. Former WWE Superstars Paige and Maryse also star in the film.
Previous Next
Christmas bonus
Prior to Santa’s Little Helper, The Miz also starred in the TV movie Christmas Bounty. It also features Francia Raisa, Will Greenberg and Chelan Simmons.
Previous Next
The Big Show: Christmas
(Photo : Netflix)
WWE’s The Big Show had its own series on Netflix, but it was canceled after one season. In the final episode, the cast of The Big Show Show reunite for a special Christmas episode, which can now be seen on the streaming service.
previous
We want to thank the writer of this post for this remarkable content
";}s:7:"summary";s:568:"Christmas is just a few days away, which means that Christmas movies and specials are dominating the world of film and television. And while there are classic movies and specials that everyone should see, the real question is, which are the best for sports fans? If there’s one that stands out, it has to be ... Read more";s:12:"atom_content";s:5015:"
Christmas is just a few days away, which means that Christmas movies and specials are dominating the world of film and television. And while there are classic movies and specials that everyone should see, the real question is, which are the best for sports fans? If there’s one that stands out, it has to be Rocky IV starring Sylvester Stallone and Dolph Lundgren. It might not be a Christmas movie for the average fan, but Christmas plays a big part in the story.
David Maars of The Daily Squat wrote: ?If your childhood Christmases were like mine, watching two men fight was a frequent occurrence, so nothing puts me in the Christmas spirit like Rocky IV. And whether or not ?Rocky IV? is a Christmas movie that’s not even up for debate. The climactic fight between Rocky Balboa and Ivan Drago takes place on December 25. For the unlit, it’s Christmas Day. ”
Rocky IV is a nontraditional Christmas movie, but there are others on this list that feature WWE Superstars, an iconic hockey team, and a lovable soccer coach. Here’s a look at the best Christmas movies and holiday specials for sports fans.
Holiday special ‘Ted Lasso’
(Photo : Apple TV)
Ted Lasso is a huge hit for Apple TV + because he’s won multiple Emmy Awards. This year, AppleTV + released a five-minute animated special that features the voices of the cast of Ted Lasso, including Jason Sudeikis, Hannah Waddingham, and Brett Goldstein. The special can be seen on AppleTV + or on its YouTube page.
Previous Next
Robbie the Reindeer: Fire Hooves
This animated special follows Robbie, a reindeer looking to join Santa’s sleigh team, just like his father Rudolph. He travels to the North Pole and meets Blitzen, who seeks to “destroy” Robbie.
Previous Next
Santa Claus with muscles
Everyone’s talking about the best Christmas movies? but what about the worst?
Here’s mine: “Santa with Muscles” with Hulk Hogan. pic.twitter.com/QO0uFcoHxk
– Chuck Thomas (@chuckthomasuk) December 22, 2021
As previously mentioned, Santa with Muscles introduces Hulk Hogan, and he plays a self-made billionaire who gets into trouble after playing paintball. He is targeted by the police, which results in him hiding in a shopping mall and wearing a Santa Claus outfit. Hogan’s character bangs his head, causing amnesia and being convinced that he is Santa Claus.
Previous Next
Miracle
It’s not a Christmas movie, but there is a Christmas scene. Miracle is a film based on the United States hockey team shattering Soviet professionals at the 1980 Winter Olympics. The film was well received by critics and grossed $ 64.5 million at the box office .
Previous Next
Rocky IV
Rocky IV is not considered a Christmas movie, but the fight between Rocky and Ivan Drago takes place on Christmas Day. At the end of the fight, Rocky wished his son a Merry Christmas as he celebrated his big win.
Previous Next
Santa’s little helper
WWE’s The Miz starred in the live-action TV movie Santa’s Little Helper and played Dax and a greedy corporate man who gets fired and loses everything. He is then seen again by Bille, an elf from the North Pole, to be Santa’s little helper. Former WWE Superstars Paige and Maryse also star in the film.
Previous Next
Christmas bonus
Prior to Santa’s Little Helper, The Miz also starred in the TV movie Christmas Bounty. It also features Francia Raisa, Will Greenberg and Chelan Simmons.
Previous Next
The Big Show: Christmas
(Photo : Netflix)
WWE’s The Big Show had its own series on Netflix, but it was canceled after one season. In the final episode, the cast of The Big Show Show reunite for a special Christmas episode, which can now be seen on the streaming service.
previous
We want to thank the writer of this post for this remarkable content
";s:14:"date_timestamp";i:1640399744;}i:4;a:11:{s:5:"title";s:95:"Direct Sport CAN 2021 (Algeria / List of 28): the first for the Esperantist Mohamed Amine Touki";s:4:"link";s:115:"http://happynewbaby.com/direct-sport-can-2021-algeria-list-of-28-the-first-for-the-esperantist-mohamed-amine-touki/";s:2:"dc";a:1:{s:7:"creator";s:10:"Lance Kind";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 01:51:08 +0000";s:8:"category";s:55:"SportAlgeriaAminedirectEsperantistlistMohamedsportTouki";s:4:"guid";s:33:"https://happynewbaby.com/?p=15141";s:11:"description";s:716:"Algeria national soccer coach Djamel Belmadi revealed the list of 28 players, who are scheduled to participate in the 2021 Africa Cup of Nations (postponed until 2022, editor’s note) in Cameroon (Jan 9 – Jan 6 February). It should be noted that this is the first of the Tunisian sports defender of Esperance Mohamed Amine ... Read more";s:7:"content";a:1:{s:7:"encoded";s:3718:"
Algeria national soccer coach Djamel Belmadi revealed the list of 28 players, who are scheduled to participate in the 2021 Africa Cup of Nations (postponed until 2022, editor’s note) in Cameroon (Jan 9 – Jan 6 February).
It should be noted that this is the first of the Tunisian sports defender of Esperance Mohamed Amine Touji among the “greens”, after being distinguished with the “A” team, crowning the Arab champion of the 2021 FIFA World Cup in Doha (Qatar) .
Attacking midfielder Yassin Al-Ibrahimi (Al Rayyan / Qatar), the best player in the 2021 Arab Cup, returns to the national team after several months of absence.
On the no-show side, midfielder Hicham Boudaoui (Nice / France) was not selected, as was left winger Rachid Ghazal (Besiktas / Turkey).
15 African champions during the previous edition 2019 in Egypt appear in the list of 28 players, while 13 players participate for the first time in the final stage of the African Cup of Nations.
The Greens are preparing, starting next Monday in Doha (Qatar), with two friendlies on the list: Saturday January 1 against Gambia, and Wednesday January 5 against Ghana, before taking off the following day in favor of Douala .
The option to prepare for Doha was already taken before the recent 2019 African Cup of Nations in Egypt, which Algeria won.
The “Foxes” had played two test matches before leaving Cairo: against Burundi (1-1) and Mali (3-2).
In Group E, their teammates will begin to defend their title, on Tuesday, January 11, 2022, against Sierra Leone, at the Jaboma Stadium in Douala (2 hours), before facing Equatorial Guinea on Sunday, January 16, 2022 in Douala (8:00 am). pm), then Ivory Coast, on Thursday, January 20, 2022, at the same stadium (5:00 p.m.).
28 player roster:
Goalkeepers: Rais Mbolhi (Al-Ettifaq / Saudi Arabia), Alexandre Okija (Metz Club / France), Mustafa Al-Zaghba (DAMAC / Saudi Arabia).
";}s:7:"summary";s:716:"Algeria national soccer coach Djamel Belmadi revealed the list of 28 players, who are scheduled to participate in the 2021 Africa Cup of Nations (postponed until 2022, editor’s note) in Cameroon (Jan 9 – Jan 6 February). It should be noted that this is the first of the Tunisian sports defender of Esperance Mohamed Amine ... Read more";s:12:"atom_content";s:3718:"
Algeria national soccer coach Djamel Belmadi revealed the list of 28 players, who are scheduled to participate in the 2021 Africa Cup of Nations (postponed until 2022, editor’s note) in Cameroon (Jan 9 – Jan 6 February).
It should be noted that this is the first of the Tunisian sports defender of Esperance Mohamed Amine Touji among the “greens”, after being distinguished with the “A” team, crowning the Arab champion of the 2021 FIFA World Cup in Doha (Qatar) .
Attacking midfielder Yassin Al-Ibrahimi (Al Rayyan / Qatar), the best player in the 2021 Arab Cup, returns to the national team after several months of absence.
On the no-show side, midfielder Hicham Boudaoui (Nice / France) was not selected, as was left winger Rachid Ghazal (Besiktas / Turkey).
15 African champions during the previous edition 2019 in Egypt appear in the list of 28 players, while 13 players participate for the first time in the final stage of the African Cup of Nations.
The Greens are preparing, starting next Monday in Doha (Qatar), with two friendlies on the list: Saturday January 1 against Gambia, and Wednesday January 5 against Ghana, before taking off the following day in favor of Douala .
The option to prepare for Doha was already taken before the recent 2019 African Cup of Nations in Egypt, which Algeria won.
The “Foxes” had played two test matches before leaving Cairo: against Burundi (1-1) and Mali (3-2).
In Group E, their teammates will begin to defend their title, on Tuesday, January 11, 2022, against Sierra Leone, at the Jaboma Stadium in Douala (2 hours), before facing Equatorial Guinea on Sunday, January 16, 2022 in Douala (8:00 am). pm), then Ivory Coast, on Thursday, January 20, 2022, at the same stadium (5:00 p.m.).
28 player roster:
Goalkeepers: Rais Mbolhi (Al-Ettifaq / Saudi Arabia), Alexandre Okija (Metz Club / France), Mustafa Al-Zaghba (DAMAC / Saudi Arabia).
";s:14:"date_timestamp";i:1640397068;}i:5;a:11:{s:5:"title";s:57:"COVID-19 infection detected in deer in six Ohio locations";s:4:"link";s:82:"http://happynewbaby.com/covid-19-infection-detected-in-deer-in-six-ohio-locations/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 01:31:19 +0000";s:8:"category";s:59:"Health And ScienceCOVID19deerdetectedInfectionlocationsOhio";s:4:"guid";s:32:"http://happynewbaby.com/?p=15136";s:11:"description";s:682:"Journal Reference: Vanessa L. Hale, Patricia M. Dennis, Dillon S. McBride, Jaqueline M. Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jennifer Grieser, Jenessa Winston, Dusty Lombardi, Stormy Gibson, Linda Saif, Mary L. Killian, Kristina Lantz, Rachel Tell, Mia Torchetti, Suelee Robbe-Austerman, Martha I. Nelson, Seth A. Faith, Andrew S. Bowman. SARS-CoV-2 infection in free-ranging white-tailed ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6008:"
Journal Reference:
Vanessa L. Hale, Patricia M. Dennis, Dillon S. McBride, Jaqueline M. Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jennifer Grieser, Jenessa Winston, Dusty Lombardi, Stormy Gibson, Linda Saif, Mary L. Killian, Kristina Lantz, Rachel Tell, Mia Torchetti, Suelee Robbe-Austerman, Martha I. Nelson, Seth A. Faith, Andrew S. Bowman. SARS-CoV-2 infection in free-ranging white-tailed deer. Nature, Dec. 23, 2021; DOI: 10.1038/s41586-021-04353-x
Previous research led by the U.S. Department of Agriculture had shown evidence of antibodies in wild deer. This study, published today (Dec. 23, 2021) in Nature, details the first report of active COVID-19 infection in white-tailed deer supported by the growth of viral isolates in the lab, indicating researchers had recovered viable samples of the SARS-CoV-2 virus and not only its genetic traces.
Based on genomic sequencing of the samples collected between January and March 2021, researchers determined that variants infecting wild deer matched strains of the SARS-CoV-2 virus that had been prevalent in Ohio COVID-19 patients at the time. Sample collection occurred before the Delta variant was widespread, and that variant was not detected in these deer. The team is testing more samples to check for new variants as well as older variants, whose continued presence would suggest the virus can set up shop and survive in this species.
The fact that wild deer can become infected ?leads toward the idea that we might actually have established a new maintenance host outside humans,? said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and senior author of the paper.
?Based on evidence from other studies, we knew they were being exposed in the wild and that in the lab we could infect them and the virus could transmit from deer to deer. Here, we?re saying that in the wild, they are infected,? Bowman said. ?And if they can maintain it, we have a new potential source of SARS-CoV-2 coming in to humans. That would mean that beyond tracking what?s in people, we?ll need to know what?s in the deer, too.
?It could complicate future mitigation and control plans for COVID-19.?
A lot of unknowns remain: how the deer got infected, whether they can infect humans and other species, how the virus behaves in the animals? body, and whether it?s a transient or long-term infection.
The research team took nasal swabs from 360 white-tailed deer in nine northeast Ohio locations. Using PCR testing methods, the scientists detected genetic material from at least three different strains of the virus in 129 (35.8%) of the deer sampled.
The analysis showed that B.1.2 viruses dominant in Ohio in the early months of 2021 spilled over multiple times into deer populations in different locations.
?The working theory based on our sequences is that humans are giving it to deer, and apparently we gave it to them several times,? Bowman said. ?We have evidence of six different viral introductions into those deer populations. It?s not that a single population got it once and it spread.?
Each site was sampled between one and three times, adding up to a total of 18 sample collection dates. Based on the findings, researchers estimated the prevalence of infection varied from 13.5% to 70% across the nine sites, with the highest prevalence observed in four sites that were surrounded by more densely populated neighborhoods.
White-tailed deer functioning as a viral reservoir of SARS-CoV-2 would likely result in one of two outcomes, Bowman said. The virus could mutate in deer, potentially facilitating transmission of new strains to other species, including humans, or the virus could survive in deer unmutated while it simultaneously continues to evolve in humans, and at some point when humans don?t have immunity to the strains infecting deer, those variants could come spilling back to humans.
How transmission happened initially in these deer, and how it could happen across species, are among the pending questions related to these findings. The research team speculated that white-tailed deer were infected through an environmental pathway ? possibly by drinking contaminated water. Research has shown that the virus is shed in human stool and detectable in wastewater.
The white-tailed deer tested for this study were part of a population control initiative, so they are not a transmission threat.
Though there are an estimated 600,000 white-tailed deer in Ohio and 30 million in the United States, Bowman said this sampling focused on locations close to dense human populations and is not representative of all free-ranging deer.
This work was supported by the Ohio State Infectious Diseases Institute and the National Institute of Allergy and Infectious Diseases. In addition to USDA, NIAID, Ohio Wildlife Center and Cleveland Metroparks contributors, Ohio State co-authors include Vanessa Hale, Patricia Dennis, Dillon McBride, Jacqueline Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jenessa Winston, Dubraska Diaz-Campos, Page Yaxley, Alexis McLaine, Risa Pesapane, Mark Flint, Jaylene Flint, Anastasia Vlasova, Scott Kenney, Qiuhong Wang, Linda Saif and Seth Faith.
We would love to say thanks to the writer of this short article for this amazing web content
";}s:7:"summary";s:682:"Journal Reference: Vanessa L. Hale, Patricia M. Dennis, Dillon S. McBride, Jaqueline M. Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jennifer Grieser, Jenessa Winston, Dusty Lombardi, Stormy Gibson, Linda Saif, Mary L. Killian, Kristina Lantz, Rachel Tell, Mia Torchetti, Suelee Robbe-Austerman, Martha I. Nelson, Seth A. Faith, Andrew S. Bowman. SARS-CoV-2 infection in free-ranging white-tailed ... Read more";s:12:"atom_content";s:6008:"
Journal Reference:
Vanessa L. Hale, Patricia M. Dennis, Dillon S. McBride, Jaqueline M. Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jennifer Grieser, Jenessa Winston, Dusty Lombardi, Stormy Gibson, Linda Saif, Mary L. Killian, Kristina Lantz, Rachel Tell, Mia Torchetti, Suelee Robbe-Austerman, Martha I. Nelson, Seth A. Faith, Andrew S. Bowman. SARS-CoV-2 infection in free-ranging white-tailed deer. Nature, Dec. 23, 2021; DOI: 10.1038/s41586-021-04353-x
Previous research led by the U.S. Department of Agriculture had shown evidence of antibodies in wild deer. This study, published today (Dec. 23, 2021) in Nature, details the first report of active COVID-19 infection in white-tailed deer supported by the growth of viral isolates in the lab, indicating researchers had recovered viable samples of the SARS-CoV-2 virus and not only its genetic traces.
Based on genomic sequencing of the samples collected between January and March 2021, researchers determined that variants infecting wild deer matched strains of the SARS-CoV-2 virus that had been prevalent in Ohio COVID-19 patients at the time. Sample collection occurred before the Delta variant was widespread, and that variant was not detected in these deer. The team is testing more samples to check for new variants as well as older variants, whose continued presence would suggest the virus can set up shop and survive in this species.
The fact that wild deer can become infected ?leads toward the idea that we might actually have established a new maintenance host outside humans,? said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and senior author of the paper.
?Based on evidence from other studies, we knew they were being exposed in the wild and that in the lab we could infect them and the virus could transmit from deer to deer. Here, we?re saying that in the wild, they are infected,? Bowman said. ?And if they can maintain it, we have a new potential source of SARS-CoV-2 coming in to humans. That would mean that beyond tracking what?s in people, we?ll need to know what?s in the deer, too.
?It could complicate future mitigation and control plans for COVID-19.?
A lot of unknowns remain: how the deer got infected, whether they can infect humans and other species, how the virus behaves in the animals? body, and whether it?s a transient or long-term infection.
The research team took nasal swabs from 360 white-tailed deer in nine northeast Ohio locations. Using PCR testing methods, the scientists detected genetic material from at least three different strains of the virus in 129 (35.8%) of the deer sampled.
The analysis showed that B.1.2 viruses dominant in Ohio in the early months of 2021 spilled over multiple times into deer populations in different locations.
?The working theory based on our sequences is that humans are giving it to deer, and apparently we gave it to them several times,? Bowman said. ?We have evidence of six different viral introductions into those deer populations. It?s not that a single population got it once and it spread.?
Each site was sampled between one and three times, adding up to a total of 18 sample collection dates. Based on the findings, researchers estimated the prevalence of infection varied from 13.5% to 70% across the nine sites, with the highest prevalence observed in four sites that were surrounded by more densely populated neighborhoods.
White-tailed deer functioning as a viral reservoir of SARS-CoV-2 would likely result in one of two outcomes, Bowman said. The virus could mutate in deer, potentially facilitating transmission of new strains to other species, including humans, or the virus could survive in deer unmutated while it simultaneously continues to evolve in humans, and at some point when humans don?t have immunity to the strains infecting deer, those variants could come spilling back to humans.
How transmission happened initially in these deer, and how it could happen across species, are among the pending questions related to these findings. The research team speculated that white-tailed deer were infected through an environmental pathway ? possibly by drinking contaminated water. Research has shown that the virus is shed in human stool and detectable in wastewater.
The white-tailed deer tested for this study were part of a population control initiative, so they are not a transmission threat.
Though there are an estimated 600,000 white-tailed deer in Ohio and 30 million in the United States, Bowman said this sampling focused on locations close to dense human populations and is not representative of all free-ranging deer.
This work was supported by the Ohio State Infectious Diseases Institute and the National Institute of Allergy and Infectious Diseases. In addition to USDA, NIAID, Ohio Wildlife Center and Cleveland Metroparks contributors, Ohio State co-authors include Vanessa Hale, Patricia Dennis, Dillon McBride, Jacqueline Nolting, Christopher Madden, Devra Huey, Margot Ehrlich, Jenessa Winston, Dubraska Diaz-Campos, Page Yaxley, Alexis McLaine, Risa Pesapane, Mark Flint, Jaylene Flint, Anastasia Vlasova, Scott Kenney, Qiuhong Wang, Linda Saif and Seth Faith.
We would love to say thanks to the writer of this short article for this amazing web content
";s:14:"date_timestamp";i:1640395879;}i:6;a:11:{s:5:"title";s:74:"Telecommuting, closing bars and support: the measures that come into force";s:4:"link";s:97:"http://happynewbaby.com/telecommuting-closing-bars-and-support-the-measures-that-come-into-force/";s:2:"dc";a:1:{s:7:"creator";s:8:"Ann Moon";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 01:22:12 +0000";s:8:"category";s:48:"Newsbarsclosingforcemeasuressupporttelecommuting";s:4:"guid";s:33:"https://happynewbaby.com/?p=15130";s:11:"description";s:671:"Reduction of capacity in commercial spaces and closing of bars and clubs are contested by associations representing the sectors PUB The period of containment decreed by the Government began this Saturday, which will last until January 9th. From midnight on the 25th, teleworking became mandatory for those who can adopt this modality, valid for the ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5693:"
Reduction of capacity in commercial spaces and closing of bars and clubs are contested by associations representing the sectors
PUB
The period of containment decreed by the Government began this Saturday, which will last until January 9th.
From midnight on the 25th, teleworking became mandatory for those who can adopt this modality, valid for the entire period of retention. The closure of bars and clubs is also decreed, with support given to companies, as well as day care centers and ATL, with due compensation given to families.
PUB
Likewise, a negative test is now mandatory to access tourist establishments and local accommodation, business events, weddings and baptisms, cultural shows and sports venues, the latter unless decided by the DGS.
In commercial spaces, the Government decided to reduce the capacity to one person by 5m2, in order to avoid as much as possible the concentration of people in stores and shopping centers. In addition and for the same reason, sales are prohibited during the entire holding period, from December 25th to January 9th.
For the New Year, there are also specific measures, such as the mandatory negative test for access to parties, the ban on gathering more than 10 people on public roads on New Year’s Eve and the ban on drinking alcoholic beverages on public roads .
PUB
PUB
PUB
Support for parents in the week after Christmas only for those who have children in day care centers and ATL
Support for parents in the week after Christmas, from December 25th to January 1st, will only cover those who have children in crèches or ATL. The information was confirmed by CNN Portugal with the Ministry of Labour. The form to request this support is available. here.
According to a source from the organization, the value of the support will be 66% of the worker’s base salary, paid in equal parts by the employer and by Social Security. In the case of parents sharing assistance, the value can even reach 100% of the basic salary.
The minimum value from which it will be calculated is 705 euros, equal to the national minimum wage, and the maximum of 2115 euros, equivalent to three minimum wages.
The coverage will thus be different from the week of contention announced earlier, which runs from 2 to 9 January. During this period, the support is aimed at workers with children up to 12 years of age and, in case they are teleworking, for parents with children in school up to the 4th grade.
PUB
PUB
PUB
Also on this occasion, support can reach 100% of the base salary if parents share the monitoring for at least two days each.
Bars and clubs contest measures
Speaking to CNN Portugal, the president of the National Discos Association, José Gouveia, confessed that he was concerned about the new restrictions.
?It’s a heavy blow. After 19 months closed and in November the test measure was imposed at the doors of the clubs so that customers could access them, and without the State’s capacity to carry out these same tests, it was the entrepreneurs in this area who created testing centers for the discotheques’ doors, investing in tests and in the payment of health technicians in the last two/three weeks. And now, once again at the last minute, we have not been contemplated with the care that the Government presents in relation to hotels and other sectors”, he said.
José Gouveia even considers these measures ?scandalous?, warning that parties in clubs will be replaced by illegal parties.
PUB
PUB
PUB
?A total inconsistency and it’s scandalous. And is the Government not thinking about opening the hunt to illegal parties? Illegal parties will happen. Discos will be replaced by parties in houses, parties on Thursdays, by parties in various places, where there will be no control of entrances, where there will be no testing screening?, he predicted.
Limitation of customers can be “problematic”
Rodrigo Moita de Deus, president of the Portuguese Association of Shopping Centers, anticipates difficulties with the limitations on capacity in commercial spaces.
“What experience tells us is that each time we impose these measures for a2, we risk creating gatherings outside commercial spaces, which means that we transfer problems from one place to another – or, worse, aggravate the problem. We want to avoid crowding, but every time we limit the number of people, we are creating crowds, queues that cannot be watched.”
We want to say thanks to the writer of this short article for this amazing web content
";}s:7:"summary";s:671:"Reduction of capacity in commercial spaces and closing of bars and clubs are contested by associations representing the sectors PUB The period of containment decreed by the Government began this Saturday, which will last until January 9th. From midnight on the 25th, teleworking became mandatory for those who can adopt this modality, valid for the ... Read more";s:12:"atom_content";s:5693:"
Reduction of capacity in commercial spaces and closing of bars and clubs are contested by associations representing the sectors
PUB
The period of containment decreed by the Government began this Saturday, which will last until January 9th.
From midnight on the 25th, teleworking became mandatory for those who can adopt this modality, valid for the entire period of retention. The closure of bars and clubs is also decreed, with support given to companies, as well as day care centers and ATL, with due compensation given to families.
PUB
Likewise, a negative test is now mandatory to access tourist establishments and local accommodation, business events, weddings and baptisms, cultural shows and sports venues, the latter unless decided by the DGS.
In commercial spaces, the Government decided to reduce the capacity to one person by 5m2, in order to avoid as much as possible the concentration of people in stores and shopping centers. In addition and for the same reason, sales are prohibited during the entire holding period, from December 25th to January 9th.
For the New Year, there are also specific measures, such as the mandatory negative test for access to parties, the ban on gathering more than 10 people on public roads on New Year’s Eve and the ban on drinking alcoholic beverages on public roads .
PUB
PUB
PUB
Support for parents in the week after Christmas only for those who have children in day care centers and ATL
Support for parents in the week after Christmas, from December 25th to January 1st, will only cover those who have children in crèches or ATL. The information was confirmed by CNN Portugal with the Ministry of Labour. The form to request this support is available. here.
According to a source from the organization, the value of the support will be 66% of the worker’s base salary, paid in equal parts by the employer and by Social Security. In the case of parents sharing assistance, the value can even reach 100% of the basic salary.
The minimum value from which it will be calculated is 705 euros, equal to the national minimum wage, and the maximum of 2115 euros, equivalent to three minimum wages.
The coverage will thus be different from the week of contention announced earlier, which runs from 2 to 9 January. During this period, the support is aimed at workers with children up to 12 years of age and, in case they are teleworking, for parents with children in school up to the 4th grade.
PUB
PUB
PUB
Also on this occasion, support can reach 100% of the base salary if parents share the monitoring for at least two days each.
Bars and clubs contest measures
Speaking to CNN Portugal, the president of the National Discos Association, José Gouveia, confessed that he was concerned about the new restrictions.
?It’s a heavy blow. After 19 months closed and in November the test measure was imposed at the doors of the clubs so that customers could access them, and without the State’s capacity to carry out these same tests, it was the entrepreneurs in this area who created testing centers for the discotheques’ doors, investing in tests and in the payment of health technicians in the last two/three weeks. And now, once again at the last minute, we have not been contemplated with the care that the Government presents in relation to hotels and other sectors”, he said.
José Gouveia even considers these measures ?scandalous?, warning that parties in clubs will be replaced by illegal parties.
PUB
PUB
PUB
?A total inconsistency and it’s scandalous. And is the Government not thinking about opening the hunt to illegal parties? Illegal parties will happen. Discos will be replaced by parties in houses, parties on Thursdays, by parties in various places, where there will be no control of entrances, where there will be no testing screening?, he predicted.
Limitation of customers can be “problematic”
Rodrigo Moita de Deus, president of the Portuguese Association of Shopping Centers, anticipates difficulties with the limitations on capacity in commercial spaces.
“What experience tells us is that each time we impose these measures for a2, we risk creating gatherings outside commercial spaces, which means that we transfer problems from one place to another – or, worse, aggravate the problem. We want to avoid crowding, but every time we limit the number of people, we are creating crowds, queues that cannot be watched.”
We want to say thanks to the writer of this short article for this amazing web content
";s:14:"date_timestamp";i:1640395332;}i:7;a:11:{s:5:"title";s:59:"Their love story began one Christmas morning inside a train";s:4:"link";s:84:"http://happynewbaby.com/their-love-story-began-one-christmas-morning-inside-a-train/";s:2:"dc";a:1:{s:7:"creator";s:11:"Peter River";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 01:19:44 +0000";s:8:"category";s:39:"NewsbeganChristmaslovemorningStorytrain";s:4:"guid";s:33:"https://happynewbaby.com/?p=15124";s:11:"description";s:595:"5 stories that made us smile in 2021 2:44 (CNN) ?? On Christmas morning 2011, Linda Wenger caught a Metro-North train at New York’s Grand Central Station to head upstate to Katonah. She was in her 50s and had been divorced for a decade. Her daughters always spent the holidays with their ex-husband: Wenger is ... Read more";s:7:"content";a:1:{s:7:"encoded";s:22901:"
5 stories that made us smile in 2021 2:44
(CNN) ?? On Christmas morning 2011, Linda Wenger caught a Metro-North train at New York’s Grand Central Station to head upstate to Katonah.
She was in her 50s and had been divorced for a decade. Her daughters always spent the holidays with their ex-husband: Wenger is Jewish, so she didn’t have much of an affinity for Christmas, while her ex’s new partner does celebrate the date.
Wenger’s sister’s family also celebrates Christmas. So she always traveled home to Connecticut on December 25th. And she always did it alone.
“It always seemed to me that Christmas Day was a bit lonely, because I was never with my girls,” Wenger now tells CNN Travel.
Wenger had a very successful career in marketing for a non-profit organization. She was happy with her professional side and her life in New York.
But when the train left the Manhattan terminal, he found himself pondering all this.
“I could have been a bit melancholic,” Wenger recalls.
There were only a handful of other people in Wenger’s car. Among them, a man of a similar age to hers, who was sitting opposite.
She watched him remove wallpaper and paint swatches from a bag, as he spread them out on the table in front of him.
“I just got this good vibe from him,” Wenger recalls. “I thought, ‘He’s kind of cute. And he’s alone on Christmas day.’
She thought that he had probably sat across from her to start a friendly conversation. But he seemed quite absorbed in his task.
As the city retreated into the distance, Wenger considered whether he should strike up a conversation.
Then the stranger brought out a particular floral wallpaper.
“Oh, that’s William Morris, right?” she said, recognizing one of the intricate patterns that characterize the Victorian artist’s work.
The man looked up and smiled.
It was Michael McTwigan, a New Yorker in his 60s who had separated from his wife a year or so ago.
I was on my way to volunteer at a Christmas food drive in Katonah. His boss lived in that area, and he had told him about the event, which sought to feed about 300 people during the festivities.
“It was Christmas Day and I thought, ‘Well, it would be nice to do something and I’m alone, so what can I do that is useful?'” McTwigan now tells CNN Travel.
I was looking at the wallpaper swatches to pass the time on the train and do a favor for a friend who wanted a print to match the paint color in her apartment. McTwigan, a former art critic with an aesthetic eye, had offered to help.
When Wenger mentioned William Morris, McTwigan was shocked. He suggested that she must have some artistic training to recognize the print.
Wenger explained that he had studied art history in college. McTwigan told him about his art background, adding that he was now in the marketing part.
Wenger said he also worked in marketing, specifically for a large lung cancer research charity. They began to chat about the joys, and the difficulties, of the profession they shared.
As they chatted about their lives and their respective plans for Christmas Day, the two realized that they shared a love of art, similar careers, and a drive to help others: Wenger through their work and McTwigan through of your volunteering.
“When he told me what he was going to do, I said, ‘OMG, that must be the best character benchmark I’ve ever seen. Right? Someone is going to do something so generous on Christmas Day,'” Wenger notes.
McTwigan was just as enthralled with Wenger – he’d noticed that while she didn’t downplay her career, she talked more about her connections with people than her accomplishments.
He felt that she was “very sensitive and intuitive”.
“Sensitive in the sense of being aware of other people’s feelings or moods, or whatever, and open to understanding what other people are feeling,” she says now. “She put people first, somehow that was more important than anything else.”
Once the two started talking, the conversation didn’t stop. And as the train passed through the New York countryside, they found that they enjoyed each other’s company immensely.
“He had a very kind and sweet vibe,” Wenger says. “And I thought, ‘Okay, this is something.’ I felt something between us. ‘
The trip from Grand Central to Katonah takes just over an hour. In no time they were entering Katonah’s small platform, shrouded in trees.
When the train stopped, Wenger reached into her purse and handed McTwigan her business card.
The two then got off the train together and down the station stairs to ground level, where Wenger’s mother was waiting to pick her up.
Wenger and McTwigan shook hands to say goodbye. When their hands touched, McTwigan touched up on Wenger’s arm and held him for a moment.
“Nice to meet you,” he said, smiling.
Wenger refers to this gesture as “the sweetest thing.”
“It definitely made my heart pound with it,” he says now.
When Wenger got into his mother’s car – and later, while chatting with his sister and the rest of his family – he recounted what had happened on the train.
“I met this really interesting man,” he explained.
“Yes, there was something going on between you,” Wenger’s mother said, laughing. She had seen the prolonged handshake from the car.
“I was a little excited about it,” Wenger says.
McTwigan also kept thinking about that meeting on the train.
“I really wanted to see Linda again,” he says. “There was no question in my mind about it.”
A first date in New York
Over the Christmas and New Years period, the two exchanged a few emails.
McTwigan then asked if Wenger would like to see each other when they are both back in town. He suggested a live event in New York, led by storytellers group The Moth.
As real people took the stage and told their stories, Wenger and McTwigan picked up their conversation right where they left off at the Katonah station.
They had a series of subsequent dates in New York City. Some, they say, more successful than others: a pop-up guitar gig suggested by McTwigan turned a bit awkward when they realized the music was quite experimental.
“We didn’t know each other well enough to say, ‘This is really awful,’ right away,” Wenger recalls, laughing.
But then the two of them went to Joe’s Pub in the East Village, where a jazz singer serenaded the audience.
“We were laughing and dancing, and that completely broke the ice,” says Wenger.
They say they took their flirting day by day and tried not to have expectations.
They were both married before, and they approached falling in love again with excitement and fear.
“‘Let’s go slow and see what happens, because, after all, we know the dangers of choosing wrong,’ was his mantra, says McTwigan.
“But especially as we lived more experiences together, all the similarities – the similar feelings and values ??- became clear to each of us, I think. We got closer,” he adds.
“We were both very happy together, which was something we hadn’t had in a long time, both of us,” says Wenger. “Much happiness, that becomes very addictive.”
The relationship just felt natural, they say, and that was part of the appeal, too: They enjoyed spending time together and loved each other’s friends and family.
A return trip
Here are McTwigan and Wenger on the Metro-North train on Christmas Day 2012, the first anniversary of their meeting. (Credit: Linda Wenger)
On Christmas Day 2012, the two boarded the Metro-North train at Grand Station to Katonah, just as they had done the year before. But, with the difference that 12 months ago they were strangers and now they were a couple who traveled together to visit Wenger’s family.
Instead of sitting across from each other, they sat together, shoulder to shoulder.
They asked another passenger to take their picture, which started a tradition.
“Every year when we would get on that train, we would take a picture or ask someone to do it,” Wenger says.
“Every year was like an anniversary, it was wonderful,” says McTwigan.
The two soon moved in together. Wenger crossed the Hudson River from his base in Manhattan to live with McTwigan in Brooklyn.
They were in Brooklyn for six years, traveling every Christmas to Katonah, before moving to Connecticut in 2018.
They love the community in their new neighborhood and enjoy the evenings spent in their garden. The only downside is that when Christmas rolls around, the two of them no longer need to take the train to Wenger’s sister’s house, as they are close enough to drive.
“A Christmas miracle”
Here are McTwigan and Wenger on Christmas Day 2015, once again on the train to Katonah. (Credit: Linda Wenger)
Wenger and McTwigan tied the knot in July 2018, at their Connecticut home.
“We just did it together,” Wenger says. And he explains that they took advantage of a moment when Wenger’s eldest daughter, whose family lives abroad, was back in the United States.
It was a warm and relaxed event, the two say. Friends and family filled the rooms of his house, eating smoked meat. One of McTwigan’s longtime friends officiated at the service.
“I think what we talked about next was that it felt like an outpouring of love for us,” Wenger says. “People were so happy that we had met. So it was a wonderful day for us.”
In their vows, the two celebrated the “Christmas miracle” that brought them together: “A Christmas miracle for a Jewish girl,” as Wenger puts it.
“It’s crazy to meet someone in such a random way, with whom you have so much happiness, peace and so much in common,” he says.
Everyone who knows them loves the story, he says.
“It was an unusual chance encounter,” says McTwigan.
“But I mean, we didn’t meet in Paris,” Wenger adds, laughing. “We met at Metro-North, a commuter train. But it worked.”
10 years later
Here are Wenger and McTwigan on vacation in Capri, Italy, in 2015. (Credit: Linda Wenger)
This Christmas marks 10 years since Wenger and McTwigan sat across from each other on the train.
Unfortunately, the two will not be able to visit Wenger’s sister in Connecticut this year. The annual Christmas gathering was canceled on December 22, when Wenger’s niece tested positive for COVID-19.
Instead, Wenger and McTwigan will celebrate together at home, just the two of them, eating all the appetizers they prepared for the family reunion that would be the largest.
While they will miss their family and the pandemic is a concern, they both say they love spending time in each other’s company. So they will make the most of the day together, as they do every day, feeling grateful that they met and took a risk.
The two hope their story inspires people to open up to new experiences and take advantage of the moments that come their way, no matter how unexpected.
“Always be prepared to take an opportunity, because you never know where it will lead, some will work and some will not, and that’s okay,” says McTwigan. “But you should not go through life with a narrow focus, but look around you and take in everything that surrounds you and enjoy it. That is my conclusion.”
“Yes, have an open heart,” says Wenger. “And also, I think that a lot of people who are alone and don’t want to be alone can have the feeling that nothing is going to change. And I went through a very long time being alone.”
“I always had the attitude that something could change, something good could happen, and I wouldn’t be alone. And maybe that’s what made me the type of person who walks up to a stranger and asks a question, to make this happen. […] I kept my heart open. ”
We would like to thank the writer of this write-up for this outstanding content
";}s:7:"summary";s:595:"5 stories that made us smile in 2021 2:44 (CNN) ?? On Christmas morning 2011, Linda Wenger caught a Metro-North train at New York’s Grand Central Station to head upstate to Katonah. She was in her 50s and had been divorced for a decade. Her daughters always spent the holidays with their ex-husband: Wenger is ... Read more";s:12:"atom_content";s:22901:"
5 stories that made us smile in 2021 2:44
(CNN) ?? On Christmas morning 2011, Linda Wenger caught a Metro-North train at New York’s Grand Central Station to head upstate to Katonah.
She was in her 50s and had been divorced for a decade. Her daughters always spent the holidays with their ex-husband: Wenger is Jewish, so she didn’t have much of an affinity for Christmas, while her ex’s new partner does celebrate the date.
Wenger’s sister’s family also celebrates Christmas. So she always traveled home to Connecticut on December 25th. And she always did it alone.
“It always seemed to me that Christmas Day was a bit lonely, because I was never with my girls,” Wenger now tells CNN Travel.
Wenger had a very successful career in marketing for a non-profit organization. She was happy with her professional side and her life in New York.
But when the train left the Manhattan terminal, he found himself pondering all this.
“I could have been a bit melancholic,” Wenger recalls.
There were only a handful of other people in Wenger’s car. Among them, a man of a similar age to hers, who was sitting opposite.
She watched him remove wallpaper and paint swatches from a bag, as he spread them out on the table in front of him.
“I just got this good vibe from him,” Wenger recalls. “I thought, ‘He’s kind of cute. And he’s alone on Christmas day.’
She thought that he had probably sat across from her to start a friendly conversation. But he seemed quite absorbed in his task.
As the city retreated into the distance, Wenger considered whether he should strike up a conversation.
Then the stranger brought out a particular floral wallpaper.
“Oh, that’s William Morris, right?” she said, recognizing one of the intricate patterns that characterize the Victorian artist’s work.
The man looked up and smiled.
It was Michael McTwigan, a New Yorker in his 60s who had separated from his wife a year or so ago.
I was on my way to volunteer at a Christmas food drive in Katonah. His boss lived in that area, and he had told him about the event, which sought to feed about 300 people during the festivities.
“It was Christmas Day and I thought, ‘Well, it would be nice to do something and I’m alone, so what can I do that is useful?'” McTwigan now tells CNN Travel.
I was looking at the wallpaper swatches to pass the time on the train and do a favor for a friend who wanted a print to match the paint color in her apartment. McTwigan, a former art critic with an aesthetic eye, had offered to help.
When Wenger mentioned William Morris, McTwigan was shocked. He suggested that she must have some artistic training to recognize the print.
Wenger explained that he had studied art history in college. McTwigan told him about his art background, adding that he was now in the marketing part.
Wenger said he also worked in marketing, specifically for a large lung cancer research charity. They began to chat about the joys, and the difficulties, of the profession they shared.
As they chatted about their lives and their respective plans for Christmas Day, the two realized that they shared a love of art, similar careers, and a drive to help others: Wenger through their work and McTwigan through of your volunteering.
“When he told me what he was going to do, I said, ‘OMG, that must be the best character benchmark I’ve ever seen. Right? Someone is going to do something so generous on Christmas Day,'” Wenger notes.
McTwigan was just as enthralled with Wenger – he’d noticed that while she didn’t downplay her career, she talked more about her connections with people than her accomplishments.
He felt that she was “very sensitive and intuitive”.
“Sensitive in the sense of being aware of other people’s feelings or moods, or whatever, and open to understanding what other people are feeling,” she says now. “She put people first, somehow that was more important than anything else.”
Once the two started talking, the conversation didn’t stop. And as the train passed through the New York countryside, they found that they enjoyed each other’s company immensely.
“He had a very kind and sweet vibe,” Wenger says. “And I thought, ‘Okay, this is something.’ I felt something between us. ‘
The trip from Grand Central to Katonah takes just over an hour. In no time they were entering Katonah’s small platform, shrouded in trees.
When the train stopped, Wenger reached into her purse and handed McTwigan her business card.
The two then got off the train together and down the station stairs to ground level, where Wenger’s mother was waiting to pick her up.
Wenger and McTwigan shook hands to say goodbye. When their hands touched, McTwigan touched up on Wenger’s arm and held him for a moment.
“Nice to meet you,” he said, smiling.
Wenger refers to this gesture as “the sweetest thing.”
“It definitely made my heart pound with it,” he says now.
When Wenger got into his mother’s car – and later, while chatting with his sister and the rest of his family – he recounted what had happened on the train.
“I met this really interesting man,” he explained.
“Yes, there was something going on between you,” Wenger’s mother said, laughing. She had seen the prolonged handshake from the car.
“I was a little excited about it,” Wenger says.
McTwigan also kept thinking about that meeting on the train.
“I really wanted to see Linda again,” he says. “There was no question in my mind about it.”
A first date in New York
Over the Christmas and New Years period, the two exchanged a few emails.
McTwigan then asked if Wenger would like to see each other when they are both back in town. He suggested a live event in New York, led by storytellers group The Moth.
As real people took the stage and told their stories, Wenger and McTwigan picked up their conversation right where they left off at the Katonah station.
They had a series of subsequent dates in New York City. Some, they say, more successful than others: a pop-up guitar gig suggested by McTwigan turned a bit awkward when they realized the music was quite experimental.
“We didn’t know each other well enough to say, ‘This is really awful,’ right away,” Wenger recalls, laughing.
But then the two of them went to Joe’s Pub in the East Village, where a jazz singer serenaded the audience.
“We were laughing and dancing, and that completely broke the ice,” says Wenger.
They say they took their flirting day by day and tried not to have expectations.
They were both married before, and they approached falling in love again with excitement and fear.
“‘Let’s go slow and see what happens, because, after all, we know the dangers of choosing wrong,’ was his mantra, says McTwigan.
“But especially as we lived more experiences together, all the similarities – the similar feelings and values ??- became clear to each of us, I think. We got closer,” he adds.
“We were both very happy together, which was something we hadn’t had in a long time, both of us,” says Wenger. “Much happiness, that becomes very addictive.”
The relationship just felt natural, they say, and that was part of the appeal, too: They enjoyed spending time together and loved each other’s friends and family.
A return trip
Here are McTwigan and Wenger on the Metro-North train on Christmas Day 2012, the first anniversary of their meeting. (Credit: Linda Wenger)
On Christmas Day 2012, the two boarded the Metro-North train at Grand Station to Katonah, just as they had done the year before. But, with the difference that 12 months ago they were strangers and now they were a couple who traveled together to visit Wenger’s family.
Instead of sitting across from each other, they sat together, shoulder to shoulder.
They asked another passenger to take their picture, which started a tradition.
“Every year when we would get on that train, we would take a picture or ask someone to do it,” Wenger says.
“Every year was like an anniversary, it was wonderful,” says McTwigan.
The two soon moved in together. Wenger crossed the Hudson River from his base in Manhattan to live with McTwigan in Brooklyn.
They were in Brooklyn for six years, traveling every Christmas to Katonah, before moving to Connecticut in 2018.
They love the community in their new neighborhood and enjoy the evenings spent in their garden. The only downside is that when Christmas rolls around, the two of them no longer need to take the train to Wenger’s sister’s house, as they are close enough to drive.
“A Christmas miracle”
Here are McTwigan and Wenger on Christmas Day 2015, once again on the train to Katonah. (Credit: Linda Wenger)
Wenger and McTwigan tied the knot in July 2018, at their Connecticut home.
“We just did it together,” Wenger says. And he explains that they took advantage of a moment when Wenger’s eldest daughter, whose family lives abroad, was back in the United States.
It was a warm and relaxed event, the two say. Friends and family filled the rooms of his house, eating smoked meat. One of McTwigan’s longtime friends officiated at the service.
“I think what we talked about next was that it felt like an outpouring of love for us,” Wenger says. “People were so happy that we had met. So it was a wonderful day for us.”
In their vows, the two celebrated the “Christmas miracle” that brought them together: “A Christmas miracle for a Jewish girl,” as Wenger puts it.
“It’s crazy to meet someone in such a random way, with whom you have so much happiness, peace and so much in common,” he says.
Everyone who knows them loves the story, he says.
“It was an unusual chance encounter,” says McTwigan.
“But I mean, we didn’t meet in Paris,” Wenger adds, laughing. “We met at Metro-North, a commuter train. But it worked.”
10 years later
Here are Wenger and McTwigan on vacation in Capri, Italy, in 2015. (Credit: Linda Wenger)
This Christmas marks 10 years since Wenger and McTwigan sat across from each other on the train.
Unfortunately, the two will not be able to visit Wenger’s sister in Connecticut this year. The annual Christmas gathering was canceled on December 22, when Wenger’s niece tested positive for COVID-19.
Instead, Wenger and McTwigan will celebrate together at home, just the two of them, eating all the appetizers they prepared for the family reunion that would be the largest.
While they will miss their family and the pandemic is a concern, they both say they love spending time in each other’s company. So they will make the most of the day together, as they do every day, feeling grateful that they met and took a risk.
The two hope their story inspires people to open up to new experiences and take advantage of the moments that come their way, no matter how unexpected.
“Always be prepared to take an opportunity, because you never know where it will lead, some will work and some will not, and that’s okay,” says McTwigan. “But you should not go through life with a narrow focus, but look around you and take in everything that surrounds you and enjoy it. That is my conclusion.”
“Yes, have an open heart,” says Wenger. “And also, I think that a lot of people who are alone and don’t want to be alone can have the feeling that nothing is going to change. And I went through a very long time being alone.”
“I always had the attitude that something could change, something good could happen, and I wouldn’t be alone. And maybe that’s what made me the type of person who walks up to a stranger and asks a question, to make this happen. […] I kept my heart open. ”
We would like to thank the writer of this write-up for this outstanding content
";s:14:"date_timestamp";i:1640395184;}i:8;a:11:{s:5:"title";s:57:"In game to meet the table, Flamengo only draws with Sport";s:4:"link";s:81:"http://happynewbaby.com/in-game-to-meet-the-table-flamengo-only-draws-with-sport/";s:2:"dc";a:1:{s:7:"creator";s:9:"Jet Tyler";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 01:19:11 +0000";s:8:"category";s:36:"SportdrawsFlamengoGameMeetsporttable";s:4:"guid";s:33:"https://happynewbaby.com/?p=15118";s:11:"description";s:588:"In a busy match, Sport and Flamengo were tied by 1-1, this Friday, in Recife. With the result, the cariocas reached 71 points. Pernambucans, on the other hand, were ranked 34th. Flamengo was superior in the first half and opened the scoring with Michael. In the final stage, Sport drew with Gustavo Oliveira. In the ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5957:"
In a busy match, Sport and Flamengo were tied by 1-1, this Friday, in Recife. With the result, the cariocas reached 71 points. Pernambucans, on the other hand, were ranked 34th.
Flamengo was superior in the first half and opened the scoring with Michael. In the final stage, Sport drew with Gustavo Oliveira.
In the next round, Flamengo will host Santos, this Monday, at Maracanã. On the same day, Sport played a relegated duel with Chapecoense, at Arena Condá.
In game to meet the table, Flamengo only draws with Sport
Photo: Marlon Costa / Futura Press
The game
The confrontation started at high speed. So much so that Flamengo almost opened the scoring after two minutes. Vitinho made a good play and crossed to Michael, who sent him through the end line. Only Sport responded to the six. Hernanes took advantage of a cross and submitted it to a great defense by Hugo Souza.
The match continued with both teams facing the attack. The cariocas had a good chance in the tenth minute, when Pedro saw Maílson ahead and tried from far away. Only the ball went over the end line.
From there, the duel was more concentrated in the middle. Flamengo had more possession and almost scored in the 28th minute. Michael took advantage of the rebound by goalkeeper Maílson, but again missed the target. After so much insisting, Michael opened the scoreboard to the Cariocas. The striker took advantage of Pedro’s cross and sent it to the net.
Even ahead in the marker, Flamengo continued with the offensive posture in the final minutes. So much so that in stoppage time, Pedro submitted with a chest, but saw Maílson Save Sport before the break.
Sport returned with another posture in the second half. So much so that within five minutes, the owners of the house tied in Recife. Gustavo Oliveira took advantage of Matheuzinho’s failure, beat Rodrigo Caio and kicked Hugo Souza out.
Flamengo took a while, but began to dominate the game again. However, cariocas had difficulty creating good chances. Sport almost turned in the 28th minute. Mikael took advantage of a cross and headed for a great defense by Hugo Souza.
The bid excited the owners of the house. So much so that Sport almost scored in the 36th minute. Sander played for Zé Welison, who finished for goal. But David Luiz appeared to save Flamengo.
In the final minutes, the two teams pursued the attack without much organization. Flamengo still ended up with a player less because Michael felt an injury and the Cariocas had already made the substitutions.
DATASHEET SPORT 1 X 1 FLAMENGO
Local: Arena Pernambuco, in São Lourenço da Mata (PE) Data: Friday, December 3, 2021 Hour: 8:00 pm (Brasilia) Referee: Leandro Pedro Vuaden (RS) Assistants: Jorge Eduardo Bernardi (RS) and José Eduardo Calza (RS) WHERE: Jean Pierre Gonçalves Lima (RS) Yellow cards: Hernanes and Paulinho Moccelin (Sport); Renê, Bruno Viana and Pedro (Flemish)
GOALS SPORT: Gustavo Oliveira, at 5min of the second half FLAMENGO: Michael, at 39 min of the first half
SPORT: Mailson, Ewerthon (Rhayner), Rafael Thyere, Sabino and Sander; Marcão Silva, José Wellison, Gustavo Oliveira (Tréllez), Hernanes (Paulinho Moccelin) and Everton Felipe (Ronaldo); Mikael Technical: Gustavo Florentin
FLAMENGO: Hugo Souza, Matheuzinho (Rodinei), Rodrigo Caio, David Luiz and Renê (Ramon); Thiago Maia (Bruno Viana), Diego (João Gomes) and Vitinho (Kenedy); Michael, Pedro and Bruno Henrique Technical: Mauricio Souza
We want to say thanks to the author of this write-up for this remarkable web content
";}s:7:"summary";s:588:"In a busy match, Sport and Flamengo were tied by 1-1, this Friday, in Recife. With the result, the cariocas reached 71 points. Pernambucans, on the other hand, were ranked 34th. Flamengo was superior in the first half and opened the scoring with Michael. In the final stage, Sport drew with Gustavo Oliveira. In the ... Read more";s:12:"atom_content";s:5957:"
In a busy match, Sport and Flamengo were tied by 1-1, this Friday, in Recife. With the result, the cariocas reached 71 points. Pernambucans, on the other hand, were ranked 34th.
Flamengo was superior in the first half and opened the scoring with Michael. In the final stage, Sport drew with Gustavo Oliveira.
In the next round, Flamengo will host Santos, this Monday, at Maracanã. On the same day, Sport played a relegated duel with Chapecoense, at Arena Condá.
In game to meet the table, Flamengo only draws with Sport
Photo: Marlon Costa / Futura Press
The game
The confrontation started at high speed. So much so that Flamengo almost opened the scoring after two minutes. Vitinho made a good play and crossed to Michael, who sent him through the end line. Only Sport responded to the six. Hernanes took advantage of a cross and submitted it to a great defense by Hugo Souza.
The match continued with both teams facing the attack. The cariocas had a good chance in the tenth minute, when Pedro saw Maílson ahead and tried from far away. Only the ball went over the end line.
From there, the duel was more concentrated in the middle. Flamengo had more possession and almost scored in the 28th minute. Michael took advantage of the rebound by goalkeeper Maílson, but again missed the target. After so much insisting, Michael opened the scoreboard to the Cariocas. The striker took advantage of Pedro’s cross and sent it to the net.
Even ahead in the marker, Flamengo continued with the offensive posture in the final minutes. So much so that in stoppage time, Pedro submitted with a chest, but saw Maílson Save Sport before the break.
Sport returned with another posture in the second half. So much so that within five minutes, the owners of the house tied in Recife. Gustavo Oliveira took advantage of Matheuzinho’s failure, beat Rodrigo Caio and kicked Hugo Souza out.
Flamengo took a while, but began to dominate the game again. However, cariocas had difficulty creating good chances. Sport almost turned in the 28th minute. Mikael took advantage of a cross and headed for a great defense by Hugo Souza.
The bid excited the owners of the house. So much so that Sport almost scored in the 36th minute. Sander played for Zé Welison, who finished for goal. But David Luiz appeared to save Flamengo.
In the final minutes, the two teams pursued the attack without much organization. Flamengo still ended up with a player less because Michael felt an injury and the Cariocas had already made the substitutions.
DATASHEET SPORT 1 X 1 FLAMENGO
Local: Arena Pernambuco, in São Lourenço da Mata (PE) Data: Friday, December 3, 2021 Hour: 8:00 pm (Brasilia) Referee: Leandro Pedro Vuaden (RS) Assistants: Jorge Eduardo Bernardi (RS) and José Eduardo Calza (RS) WHERE: Jean Pierre Gonçalves Lima (RS) Yellow cards: Hernanes and Paulinho Moccelin (Sport); Renê, Bruno Viana and Pedro (Flemish)
GOALS SPORT: Gustavo Oliveira, at 5min of the second half FLAMENGO: Michael, at 39 min of the first half
SPORT: Mailson, Ewerthon (Rhayner), Rafael Thyere, Sabino and Sander; Marcão Silva, José Wellison, Gustavo Oliveira (Tréllez), Hernanes (Paulinho Moccelin) and Everton Felipe (Ronaldo); Mikael Technical: Gustavo Florentin
FLAMENGO: Hugo Souza, Matheuzinho (Rodinei), Rodrigo Caio, David Luiz and Renê (Ramon); Thiago Maia (Bruno Viana), Diego (João Gomes) and Vitinho (Kenedy); Michael, Pedro and Bruno Henrique Technical: Mauricio Souza
We want to say thanks to the author of this write-up for this remarkable web content
";s:14:"date_timestamp";i:1640395151;}i:9;a:11:{s:5:"title";s:53:"First model to predict lifetime risk of heart failure";s:4:"link";s:78:"http://happynewbaby.com/first-model-to-predict-lifetime-risk-of-heart-failure/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sat, 25 Dec 2021 00:13:43 +0000";s:8:"category";s:54:"Health And SciencefailureHEARTlifetimemodelpredictrisk";s:4:"guid";s:32:"http://happynewbaby.com/?p=15113";s:11:"description";s:645:"Journal Reference: Sadiya S Khan, Hongyan Ning, Norrina B Allen, Mercedes Carnethon, Clyde W Yancy, Sanjiv J Shah, John T Wilkins, Lu Tian, Donald Lloyd-Jones. Development and Validation of A Long-Term Incident Heart Failure Risk Model. Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.121.319595 Such a model now exists, thanks to a new Northwestern Medicine study, which derived ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4052:"
Journal Reference:
Sadiya S Khan, Hongyan Ning, Norrina B Allen, Mercedes Carnethon, Clyde W Yancy, Sanjiv J Shah, John T Wilkins, Lu Tian, Donald Lloyd-Jones. Development and Validation of A Long-Term Incident Heart Failure Risk Model. Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.121.319595
Such a model now exists, thanks to a new Northwestern Medicine study, which derived and validated the first set of risk prediction models for lifetime risk of heart failure.
The ability to identify who is at greatest risk for heart failure ? especially among high-risk young adult populations ? will allow physicians to start prevention measures sooner.
?Once someone develops symptoms of heart failure, the window for prevention has closed, which is a missed opportunity, given that the risk of dying in the five years after diagnosis is 50%, similar to a cancer diagnosis,? said corresponding study author Dr. Sadiya Khan, assistant professor of cardiology and epidemiology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician.
Prior to this work, no models existed for estimating long-term risk for heart failure. Short-term models exist that estimate heart-failure risk in the next five to 10 years, But those aren?t as effective for young adults who may not develop heart failure until they are older.
Now, for the first time, the model will allow doctors to estimate a person?s risk of developing heart failure in the next 30 years based on their current risk factor levels, such as body mass index, blood pressure, cholesterol, diabetes and smoking status. The scientists are currently working on an online tool that could be used by physicians.
The study was recently published in Circulation Research, a journal of the American Heart Association.
Heart failure is the primary cause of one million hospitalizations and contributes to 300,000 deaths annually in the United States. That trend is only continuing to rise, Khan said.
Not all people with hypertension or obesity have the same risk for heart failure, Khan said. Currently, there are effective strategies to reduce a person?s risk of heart failure. These include lowering blood pressure or blood sugar with specific medications combined with diet and exercise. But without being able to quantify a person?s risk of developing heart failure, it is difficult to identify who should receive these prevention measures.
?These new models offer the opportunity for clinicians and patients to begin discussions at the individual level for opportunities to start prevention earlier in the life course,? Khan said. ?This moves the field forward by offering a precision approach to prevention and moving beyond risk associated with having or not having hypertension or diabetes.?
Since it is well known that risk of heart failure differs between Black and white men and women, the risk-prediction models were derived in each individual demographic subgroup, Khan said.
For example, in an average 40-year-old non-smoker with an untreated systolic blood pressure of 140 mm Hg, which is high, and body mass index of 30 kg/m2 , which is considered obese, the risk of developing heart failure was estimated to be 22.8% in a Black man, 13.7% in a white man, 13.0% in a Black woman, and 12.1% in a white woman.
We would like to give thanks to the writer of this article for this remarkable material
";}s:7:"summary";s:645:"Journal Reference: Sadiya S Khan, Hongyan Ning, Norrina B Allen, Mercedes Carnethon, Clyde W Yancy, Sanjiv J Shah, John T Wilkins, Lu Tian, Donald Lloyd-Jones. Development and Validation of A Long-Term Incident Heart Failure Risk Model. Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.121.319595 Such a model now exists, thanks to a new Northwestern Medicine study, which derived ... Read more";s:12:"atom_content";s:4052:"
Journal Reference:
Sadiya S Khan, Hongyan Ning, Norrina B Allen, Mercedes Carnethon, Clyde W Yancy, Sanjiv J Shah, John T Wilkins, Lu Tian, Donald Lloyd-Jones. Development and Validation of A Long-Term Incident Heart Failure Risk Model. Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.121.319595
Such a model now exists, thanks to a new Northwestern Medicine study, which derived and validated the first set of risk prediction models for lifetime risk of heart failure.
The ability to identify who is at greatest risk for heart failure ? especially among high-risk young adult populations ? will allow physicians to start prevention measures sooner.
?Once someone develops symptoms of heart failure, the window for prevention has closed, which is a missed opportunity, given that the risk of dying in the five years after diagnosis is 50%, similar to a cancer diagnosis,? said corresponding study author Dr. Sadiya Khan, assistant professor of cardiology and epidemiology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician.
Prior to this work, no models existed for estimating long-term risk for heart failure. Short-term models exist that estimate heart-failure risk in the next five to 10 years, But those aren?t as effective for young adults who may not develop heart failure until they are older.
Now, for the first time, the model will allow doctors to estimate a person?s risk of developing heart failure in the next 30 years based on their current risk factor levels, such as body mass index, blood pressure, cholesterol, diabetes and smoking status. The scientists are currently working on an online tool that could be used by physicians.
The study was recently published in Circulation Research, a journal of the American Heart Association.
Heart failure is the primary cause of one million hospitalizations and contributes to 300,000 deaths annually in the United States. That trend is only continuing to rise, Khan said.
Not all people with hypertension or obesity have the same risk for heart failure, Khan said. Currently, there are effective strategies to reduce a person?s risk of heart failure. These include lowering blood pressure or blood sugar with specific medications combined with diet and exercise. But without being able to quantify a person?s risk of developing heart failure, it is difficult to identify who should receive these prevention measures.
?These new models offer the opportunity for clinicians and patients to begin discussions at the individual level for opportunities to start prevention earlier in the life course,? Khan said. ?This moves the field forward by offering a precision approach to prevention and moving beyond risk associated with having or not having hypertension or diabetes.?
Since it is well known that risk of heart failure differs between Black and white men and women, the risk-prediction models were derived in each individual demographic subgroup, Khan said.
For example, in an average 40-year-old non-smoker with an untreated systolic blood pressure of 140 mm Hg, which is high, and body mass index of 30 kg/m2 , which is considered obese, the risk of developing heart failure was estimated to be 22.8% in a Black man, 13.7% in a white man, 13.0% in a Black woman, and 12.1% in a white woman.
We would like to give thanks to the writer of this article for this remarkable material
ingredients
