O:9:"MagpieRSS":24:{s:6:"parser";i:0;s:12:"current_item";a:0:{}s:5:"items";a:10:{i:0;a:11:{s:5:"title";s:83:"Guidance on supplemental breast cancer screening for women with dense breast tissue";s:4:"link";s:114:"https://moustachebrothers.com/guidance-on-supplemental-breast-cancer-screening-for-women-with-dense-breast-tissue/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 17:38:08 +0000";s:8:"category";s:75:"Health And SciencebreastcancerdenseGuidancescreeningsupplementaltissuewomen";s:4:"guid";s:36:"https://moustachebrothers.com/?p=733";s:11:"description";s:739:"Journal Reference: Suneela Vegunta, Juliana M. Kling, Bhavika K. Patel. Supplemental Cancer Screening for Women With Dense Breasts: Guidance for Health Care Professionals. Mayo Clinic Proceedings, 2021; DOI: 10.1016/j.mayocp.2021.06.001 Breast cancer is the second most common cause of cancer death in women. Although 1 in 8 women will be affected by breast cancer, early detection ... Read more";s:7:"content";a:1:{s:7:"encoded";s:3136:"
Journal Reference:
Suneela Vegunta, Juliana M. Kling, Bhavika K. Patel. Supplemental Cancer Screening for Women With Dense Breasts: Guidance for Health Care Professionals. Mayo Clinic Proceedings, 2021; DOI: 10.1016/j.mayocp.2021.06.001
Breast cancer is the second most common cause of cancer death in women. Although 1 in 8 women will be affected by breast cancer, early detection leads to improved survival.
?One challenge for some women is dense breast tissue,? says author Suneela Vegunta, M.D., a women?s health specialist at Mayo Clinic. Dr. Vegunta says there are millions of women in the U.S. with dense breast tissue. It?s found in nearly half of women eligible for breast cancer screening, particularly in younger women. She says breast density may decrease after menopause.
?Dense breast tissue is an independent risk factor for breast cancer and may also mask small breast cancers, thereby reducing the sensitivity of a screening mammogram,? says Dr. Vegunta.
She says that since legislation requiring providers to notify women about breast density was passed in several states, more women are aware of their breast density and are reaching out to health care professionals with questions.
?Supplemental breast cancer screening modalities can help diagnose additional cancers that are possibly masked by dense breast tissue on mammograms,? says Dr. Vegunta. ?Our paper provides information and guidance for health care professionals and patients on the benefits and drawbacks of various supplemental screening modalities in the background of using a risk-based stratification of patients with dense breast tissue.?
Dr. Vegunta says that dense breast tissue is only one risk factor for breast cancer. If a patient has additional risk factors, such as family history of breast cancer, experienced early menstruation, has not given birth to a child, or has a prior history of abnormal breast biopsies, she should discuss enhanced surveillance with her health care provider.
Dr. Vegunta says consensus-based guidelines are not available related to screening women with dense breast tissue. Also, randomized controlled studies have not been performed that review the effect of supplemental screening versus mammography alone on breast cancer mortality. She says these studies, along with guidelines for screening women with dense breast tissue, are needed.
We want to say thanks to the writer of this short article for this amazing web content
";}s:7:"summary";s:739:"Journal Reference: Suneela Vegunta, Juliana M. Kling, Bhavika K. Patel. Supplemental Cancer Screening for Women With Dense Breasts: Guidance for Health Care Professionals. Mayo Clinic Proceedings, 2021; DOI: 10.1016/j.mayocp.2021.06.001 Breast cancer is the second most common cause of cancer death in women. Although 1 in 8 women will be affected by breast cancer, early detection ... Read more";s:12:"atom_content";s:3136:"
Journal Reference:
Suneela Vegunta, Juliana M. Kling, Bhavika K. Patel. Supplemental Cancer Screening for Women With Dense Breasts: Guidance for Health Care Professionals. Mayo Clinic Proceedings, 2021; DOI: 10.1016/j.mayocp.2021.06.001
Breast cancer is the second most common cause of cancer death in women. Although 1 in 8 women will be affected by breast cancer, early detection leads to improved survival.
?One challenge for some women is dense breast tissue,? says author Suneela Vegunta, M.D., a women?s health specialist at Mayo Clinic. Dr. Vegunta says there are millions of women in the U.S. with dense breast tissue. It?s found in nearly half of women eligible for breast cancer screening, particularly in younger women. She says breast density may decrease after menopause.
?Dense breast tissue is an independent risk factor for breast cancer and may also mask small breast cancers, thereby reducing the sensitivity of a screening mammogram,? says Dr. Vegunta.
She says that since legislation requiring providers to notify women about breast density was passed in several states, more women are aware of their breast density and are reaching out to health care professionals with questions.
?Supplemental breast cancer screening modalities can help diagnose additional cancers that are possibly masked by dense breast tissue on mammograms,? says Dr. Vegunta. ?Our paper provides information and guidance for health care professionals and patients on the benefits and drawbacks of various supplemental screening modalities in the background of using a risk-based stratification of patients with dense breast tissue.?
Dr. Vegunta says that dense breast tissue is only one risk factor for breast cancer. If a patient has additional risk factors, such as family history of breast cancer, experienced early menstruation, has not given birth to a child, or has a prior history of abnormal breast biopsies, she should discuss enhanced surveillance with her health care provider.
Dr. Vegunta says consensus-based guidelines are not available related to screening women with dense breast tissue. Also, randomized controlled studies have not been performed that review the effect of supplemental screening versus mammography alone on breast cancer mortality. She says these studies, along with guidelines for screening women with dense breast tissue, are needed.
We want to say thanks to the writer of this short article for this amazing web content
";s:14:"date_timestamp";i:1635701888;}i:1;a:11:{s:5:"title";s:113:"Football and padel, a winning understanding. And what challenges between Totti, Albertini, Di Biagio and Candela";s:4:"link";s:139:"https://moustachebrothers.com/football-and-padel-a-winning-understanding-and-what-challenges-between-totti-albertini-di-biagio-and-candela/";s:2:"dc";a:1:{s:7:"creator";s:10:"Kent Miner";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 16:31:20 +0000";s:8:"category";s:76:"TennisAlbertiniBiagioCandelaChallengesfootballpadelTottiunderstandingWinning";s:4:"guid";s:36:"https://moustachebrothers.com/?p=730";s:11:"description";s:778:"The Cupra Padel Tour ends today. Yesterday animated by the (more or less) friendly matches between the former players, paired with the best in the ranking. The former Giallorossi captain won Francesco Pietrella October 31st – ROMA The mood of the tournament can be understood already in the middle of the morning, under the Roman ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6683:"
The Cupra Padel Tour ends today. Yesterday animated by the (more or less) friendly matches between the former players, paired with the best in the ranking. The former Giallorossi captain won
Francesco Pietrella
The mood of the tournament can be understood already in the middle of the morning, under the Roman sun, in front of a couple of beers. Four people at the table, easy to understand who lost and who “gained” a little. “So, do you pay?”. ?Yes, even if that volley didn’t touch the grate??. A classic. And down to discuss recoveries and setbacks, lost points and other lucky ones, always with a smile and respect, while on the “central” of the Pamphili Padel Club the challenge between padel players and former players is staged: Albertini, Gigi Di Biagio, Candela and Totti against ?the Messi and the Cristiano Ronaldo? of the circuit. That is Tello, Cinghotto, Tapia and Pablo Lima, four stars of the Cupra Padel Tour.
SELFIE E GAG
?
When you’ve played football for twenty years, the competition stays inside, and when you lose a point, miss a volley or miss a backhand, something snaps inside. Totti, Di Biagio, Albertini and Candela proved it once again. They called it “exhibition”, “friendly challenge”, but in the end they were given with a racket, trying out shots in front of the “real” padel players. Totti with Lima, Di Biagio with Tello, Candela with Cinghotto and Albertini with Tapia. In between, various sketches with a hint of comedy, obviously with the former Roma captain in the lead. At one point Albertini knocks out a ball that touches the grate and makes. “I can’t ask the public if he is out, everyone here in Rome cheers for you …”. The two have been playing against for some time and it shows. The level is not bad.
DENTAL SHOW
?
Candela’s smashes are for photography, Totti plays a little while standing but takes them all and teases. ?Go and take this?, he says to Demetrius, another who recovers everything. Then at a certain point Di Biagio comes out, straight along the line to a surprised Candela. ?You weren’t expecting that huh? I was a midfielder for twenty years, I have peripheral vision ?. And down cheers. Between one match and another, the former Under 21 coach checks Atalanta-Lazio to stay up to date, then resumes. Play right and recover, a bit like when he went out on the pitch. Totti, on the other hand, tries the shots and invents, by 10. They do not always succeed, but when they enter, applause fly. Candela is more silent, plays with the Roma sweatshirt and moves to the left. The quality is there, the shots as well, even Tello and Lima recognize it.
TOTTI WINS
?
Totti has fun with jokes and gags. At one point he engages in an almost endless exchange with Tapia. The Argentine raises it and Totti tries the ‘bandaja’, a shot to close. One is 22 and the other 45, but the Roma captain resists and holds out. One, two, four, eight times, then Tapia takes home the number 5 point in the ranking. ?These are Martians, they play at 5%?. Even if every now and then someone even surprises the frying pans. A couple of times Di Biagio and Totti, others Albertini and Candela. In the second match Vincent recovers a ball off the pitch and then closes the point with elegance. Applause. In the end Totti and Lima win, rewarded at the end of the game.
Teasing him to his friend Di Biagio – second with Tello – is inevitable, and arrives during the delivery of the ‘cup’ for second place. ?Strike a pose, I’ll take a picture of you?. “Then send it to me.” And laughter. Then Francesco is awarded. ?He is the first to win in padel?. At the end of the match usual selfies among the people, while on the other fields the round of 16 is played. There is also room for an amarcord. A boy stops Totti and tells him he is coming from Cesena. “You scored your last goal as a footballer against us in the Italian Cup, remember?”. “Of course?”. February 2017, 4 years ago. If he had a DeLorean he would go even further back.
TOMORROW THE FINALS
?
The tournament is about to end. After more than three thousand members and dozens of stages throughout Italy, the Pamphili Padel Club degli Argiolas is hosting the final stages. Yesterday the group stage and the round of 16 were staged, today quarterfinals, semifinals and grand final. Sixteen couples left in the competition between the men’s and women’s draws, 8 each. It was played on 11 courts, 8 outdoors and three indoors. And today we return to the field with the last phase of the tournament.
";}s:7:"summary";s:778:"The Cupra Padel Tour ends today. Yesterday animated by the (more or less) friendly matches between the former players, paired with the best in the ranking. The former Giallorossi captain won Francesco Pietrella October 31st – ROMA The mood of the tournament can be understood already in the middle of the morning, under the Roman ... Read more";s:12:"atom_content";s:6683:"
The Cupra Padel Tour ends today. Yesterday animated by the (more or less) friendly matches between the former players, paired with the best in the ranking. The former Giallorossi captain won
Francesco Pietrella
The mood of the tournament can be understood already in the middle of the morning, under the Roman sun, in front of a couple of beers. Four people at the table, easy to understand who lost and who “gained” a little. “So, do you pay?”. ?Yes, even if that volley didn’t touch the grate??. A classic. And down to discuss recoveries and setbacks, lost points and other lucky ones, always with a smile and respect, while on the “central” of the Pamphili Padel Club the challenge between padel players and former players is staged: Albertini, Gigi Di Biagio, Candela and Totti against ?the Messi and the Cristiano Ronaldo? of the circuit. That is Tello, Cinghotto, Tapia and Pablo Lima, four stars of the Cupra Padel Tour.
SELFIE E GAG
?
When you’ve played football for twenty years, the competition stays inside, and when you lose a point, miss a volley or miss a backhand, something snaps inside. Totti, Di Biagio, Albertini and Candela proved it once again. They called it “exhibition”, “friendly challenge”, but in the end they were given with a racket, trying out shots in front of the “real” padel players. Totti with Lima, Di Biagio with Tello, Candela with Cinghotto and Albertini with Tapia. In between, various sketches with a hint of comedy, obviously with the former Roma captain in the lead. At one point Albertini knocks out a ball that touches the grate and makes. “I can’t ask the public if he is out, everyone here in Rome cheers for you …”. The two have been playing against for some time and it shows. The level is not bad.
DENTAL SHOW
?
Candela’s smashes are for photography, Totti plays a little while standing but takes them all and teases. ?Go and take this?, he says to Demetrius, another who recovers everything. Then at a certain point Di Biagio comes out, straight along the line to a surprised Candela. ?You weren’t expecting that huh? I was a midfielder for twenty years, I have peripheral vision ?. And down cheers. Between one match and another, the former Under 21 coach checks Atalanta-Lazio to stay up to date, then resumes. Play right and recover, a bit like when he went out on the pitch. Totti, on the other hand, tries the shots and invents, by 10. They do not always succeed, but when they enter, applause fly. Candela is more silent, plays with the Roma sweatshirt and moves to the left. The quality is there, the shots as well, even Tello and Lima recognize it.
TOTTI WINS
?
Totti has fun with jokes and gags. At one point he engages in an almost endless exchange with Tapia. The Argentine raises it and Totti tries the ‘bandaja’, a shot to close. One is 22 and the other 45, but the Roma captain resists and holds out. One, two, four, eight times, then Tapia takes home the number 5 point in the ranking. ?These are Martians, they play at 5%?. Even if every now and then someone even surprises the frying pans. A couple of times Di Biagio and Totti, others Albertini and Candela. In the second match Vincent recovers a ball off the pitch and then closes the point with elegance. Applause. In the end Totti and Lima win, rewarded at the end of the game.
Teasing him to his friend Di Biagio – second with Tello – is inevitable, and arrives during the delivery of the ‘cup’ for second place. ?Strike a pose, I’ll take a picture of you?. “Then send it to me.” And laughter. Then Francesco is awarded. ?He is the first to win in padel?. At the end of the match usual selfies among the people, while on the other fields the round of 16 is played. There is also room for an amarcord. A boy stops Totti and tells him he is coming from Cesena. “You scored your last goal as a footballer against us in the Italian Cup, remember?”. “Of course?”. February 2017, 4 years ago. If he had a DeLorean he would go even further back.
TOMORROW THE FINALS
?
The tournament is about to end. After more than three thousand members and dozens of stages throughout Italy, the Pamphili Padel Club degli Argiolas is hosting the final stages. Yesterday the group stage and the round of 16 were staged, today quarterfinals, semifinals and grand final. Sixteen couples left in the competition between the men’s and women’s draws, 8 each. It was played on 11 courts, 8 outdoors and three indoors. And today we return to the field with the last phase of the tournament.
";s:14:"date_timestamp";i:1635697880;}i:2;a:11:{s:5:"title";s:66:"The Hawks in Philadelphia don?t fly: what a triumph for the Sixers";s:4:"link";s:95:"https://moustachebrothers.com/the-hawks-in-philadelphia-dont-fly-what-a-triumph-for-the-sixers/";s:2:"dc";a:1:{s:7:"creator";s:10:"Holly June";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 16:25:15 +0000";s:8:"category";s:36:"NBAflyHawksPhiladelphiaSixerstriumph";s:4:"guid";s:36:"https://moustachebrothers.com/?p=726";s:11:"description";s:640:"Gallinari and companions overwhelmed 122-94 in the city of brotherly love. The blue is still running in: only 4 points in 12 ‘ Demonstration of strength. And a little revenge. Philadelphia (4 won-2 lost so far) crushes Atlanta (3-3) in the first cross between the two teams after game-7 of the semifinal in East 2021, ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4958:"
Gallinari and companions overwhelmed 122-94 in the city of brotherly love. The blue is still running in: only 4 points in 12 ‘
Demonstration of strength. And a little revenge. Philadelphia (4 won-2 lost so far) crushes Atlanta (3-3) in the first cross between the two teams after game-7 of the semifinal in East 2021, that of the apotheosis of the Hawks, the collapse of the Sixers and the beginning of the crisis between Ben Simmons and the franchise of the city of brotherly love. With the Australian still in the pits, waiting to decide if and when he wants to return to the field with Philadelphia, this time Doc Rivers’ team does not miss anything, demolishing the certainties of Atlanta, knocked out for the second game in a row. Not even Danilo Gallinari is saved from the greyness of the Hawks: the blue is visibly still running in and closes with 4 points and 4 rebounds in just over 12 ‘.
THE PROBLEMS OF THE HAWKS
?
Atlanta was a disaster, too bad to be true: he shoots with 37.9% from the field, the ball never turns, not even with Trae Young who closes with 10 of the 24 total assists of the team, a number that is not enough to hide his disastrous game. (13 points with 5/16 shooting). “Physically we are healthy, but we still have to find an agreement in attack: we are out of sync, and this is reflected in our defense – explained coach McMillan at the end of the match -. Players have to figure out for themselves what’s wrong. I can say it, I can show it, but until they really understand it there is no way to improve. We have a lot of potential, but until we understand that we have to exploit it as a team there will be no way to use it ?. The least worst was Cam Reddish, who confirmed his excellent start to the season with 16 points. Atlanta, however, played too bad a game to see anything positive.
SIXERS PARTY
?
For Philadelphia, the second success in a row is another step in the right direction. The best was Tobias Harris, 22 points and 11 rebounds: “We still have a lot of work to do – he explains -, we must continue to make progress even through games like these to get to the level we want to play”. Coach Rivers didn’t even need to ask Joel Embiid for overtime, 19 points and 5 rebounds in less than 30 ‘, and used Seth Curry’s third quarter (12 of his 15 points) to dig the decisive furrow. The defense made the difference: Tyrese Maxey (16 points with 6/8 shooting) was practically perfect on Trae Young, showing that he had learned the lessons of his “mentor” Matisse Thybulle, extraordinary in destroying Hawks’ offensive intentions (4 steals and 3 blocks in 23 ‘) and also effective in attack (11 points). ?I’m improving because I have more confidence – says the Australian -. The teammates support me and encourage me to get out of my comfort zone trying to make me feel also in attack ?.
THE MATCH
?
Philadelphia takes control of the game with a 14-0 run in the first quarter, in which touch flies to 26-11 with Niang with 52 ?left. Atlanta tries to rectify the situation in the second quarter, shortening with Bogdanovic at 53-46 at 1’36 “from the rest. Phila, however, closes the half with a 7-0 run and at the start of the second half she overflows, dragged by the 12 points in the third period of Seth Curry to 89-69 that the scoreboard marks when the third siren sounds. The last quarter is just garbage time.
";}s:7:"summary";s:640:"Gallinari and companions overwhelmed 122-94 in the city of brotherly love. The blue is still running in: only 4 points in 12 ‘ Demonstration of strength. And a little revenge. Philadelphia (4 won-2 lost so far) crushes Atlanta (3-3) in the first cross between the two teams after game-7 of the semifinal in East 2021, ... Read more";s:12:"atom_content";s:4958:"
Gallinari and companions overwhelmed 122-94 in the city of brotherly love. The blue is still running in: only 4 points in 12 ‘
Demonstration of strength. And a little revenge. Philadelphia (4 won-2 lost so far) crushes Atlanta (3-3) in the first cross between the two teams after game-7 of the semifinal in East 2021, that of the apotheosis of the Hawks, the collapse of the Sixers and the beginning of the crisis between Ben Simmons and the franchise of the city of brotherly love. With the Australian still in the pits, waiting to decide if and when he wants to return to the field with Philadelphia, this time Doc Rivers’ team does not miss anything, demolishing the certainties of Atlanta, knocked out for the second game in a row. Not even Danilo Gallinari is saved from the greyness of the Hawks: the blue is visibly still running in and closes with 4 points and 4 rebounds in just over 12 ‘.
THE PROBLEMS OF THE HAWKS
?
Atlanta was a disaster, too bad to be true: he shoots with 37.9% from the field, the ball never turns, not even with Trae Young who closes with 10 of the 24 total assists of the team, a number that is not enough to hide his disastrous game. (13 points with 5/16 shooting). “Physically we are healthy, but we still have to find an agreement in attack: we are out of sync, and this is reflected in our defense – explained coach McMillan at the end of the match -. Players have to figure out for themselves what’s wrong. I can say it, I can show it, but until they really understand it there is no way to improve. We have a lot of potential, but until we understand that we have to exploit it as a team there will be no way to use it ?. The least worst was Cam Reddish, who confirmed his excellent start to the season with 16 points. Atlanta, however, played too bad a game to see anything positive.
SIXERS PARTY
?
For Philadelphia, the second success in a row is another step in the right direction. The best was Tobias Harris, 22 points and 11 rebounds: “We still have a lot of work to do – he explains -, we must continue to make progress even through games like these to get to the level we want to play”. Coach Rivers didn’t even need to ask Joel Embiid for overtime, 19 points and 5 rebounds in less than 30 ‘, and used Seth Curry’s third quarter (12 of his 15 points) to dig the decisive furrow. The defense made the difference: Tyrese Maxey (16 points with 6/8 shooting) was practically perfect on Trae Young, showing that he had learned the lessons of his “mentor” Matisse Thybulle, extraordinary in destroying Hawks’ offensive intentions (4 steals and 3 blocks in 23 ‘) and also effective in attack (11 points). ?I’m improving because I have more confidence – says the Australian -. The teammates support me and encourage me to get out of my comfort zone trying to make me feel also in attack ?.
THE MATCH
?
Philadelphia takes control of the game with a 14-0 run in the first quarter, in which touch flies to 26-11 with Niang with 52 ?left. Atlanta tries to rectify the situation in the second quarter, shortening with Bogdanovic at 53-46 at 1’36 “from the rest. Phila, however, closes the half with a 7-0 run and at the start of the second half she overflows, dragged by the 12 points in the third period of Seth Curry to 89-69 that the scoreboard marks when the third siren sounds. The last quarter is just garbage time.
";s:14:"date_timestamp";i:1635697515;}i:3;a:11:{s:5:"title";s:84:"Researchers identify genetic cause of endometriosis and reveal potential drug target";s:4:"link";s:115:"https://moustachebrothers.com/researchers-identify-genetic-cause-of-endometriosis-and-reveal-potential-drug-target/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 16:21:14 +0000";s:8:"category";s:82:"Health And SciencedrugendometriosisgeneticidentifyPotentialResearchersrevealtarget";s:4:"guid";s:36:"https://moustachebrothers.com/?p=722";s:11:"description";s:773:"Journal Reference: Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4667:"
Journal Reference:
Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather A. Simmons, Denise Brocklebank, Catherine Shang, Susan Treloar, Graham Wells, Christian M. Becker, Udo Oppermann, Thomas M. Zollner, Stephen H. Kennedy, Joseph W. Kemnitz, Jeffrey Rogers, Krina T. Zondervan. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Science Translational Medicine, 2021; 13 (608): eabd6469 DOI: 10.1126/scitranslmed.abd6469
The researchers performed genetic analyses of humans and rhesus macaques to identify a specific gene, NPSR1, that increases risk of suffering from endometriosis. The results reveal a potential new nonhormonal drug target that may lead to improved therapy. Their results are published in Science Translational Medicine.
The Oxford team, led by corresponding author Dr. Krina T. Zondervan, had previously found a genetic linkage to endometriosis on chromosome 7p13-15 by analyzing DNA from families containing at least three women diagnosed with endometriosis. The Baylor team, led by senior author Dr. Jeffrey Rogers, verified this genetic linkage in the DNA of rhesus monkeys with spontaneous endometriosis at the Wisconsin National Primate Research Center at the University of Wisconsin-Madison. This validation justified further research through in-depth sequencing analysis of the endometriosis families at Oxford, which narrowed down the genetic cause to rare variants in the NPSR1 gene. Most of the women carrying these rare variants had stage III/IV disease. The Baylor researchers similarly sequenced rhesus monkeys and again showed suggestive evidence also in this species. Finally, an Oxford study of more than 11,000 women, including patients with endometriosis and healthy women, identified a specific common variant in the NPSR1 gene also associated with stage III/IV endometriosis.
?This is one of the first examples of DNA sequencing in nonhuman primates to validate results in human studies and the first to make a significant impact on understanding the genetics of common, complex metabolic diseases,? said Rogers, associate professor at the Human Genome Sequencing Center at Baylor. ?The primate research really helped to provide confidence at each step of the genetic analysis in humans and gave us motivation to carry on chasing these particular genes.?
The insights revealed in this genetic analysis point to a potential new drug target. As part of this collaboration, researchers at Bayer, in scientific partnership with Oxford University, used an NPSR1 inhibitor to block protein signaling of that gene in cellular assays and then in mouse models of endometriosis. They found this treatment led to reduced inflammation and abdominal pain, thus identifying a target for future research in treating endometriosis.
?This is an exciting new development in our quest for new treatments of endometriosis, a debilitating and underrecognized disease affecting 190 million women worldwide. We need to do further research on the mechanism of action and the role of the genetic variants in modulation of the gene?s effects in specific tissues. However, we have a promising new nonhormonal target for further investigation and development that appears to address directly the inflammatory and pain components of the disease,? said Zondervan, head of the department of women?s and reproductive health, professor of reproductive and genomic epidemiology and co-director of the Endometriosis CaRe Centre at Oxford.
Dr. Thomas Tapmeier, now at Monash University, is co-corresponding author of the study.
We wish to thank the author of this short article for this outstanding material
";}s:7:"summary";s:773:"Journal Reference: Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather ... Read more";s:12:"atom_content";s:4667:"
Journal Reference:
Thomas T. Tapmeier, Nilufer Rahmioglu, Jianghai Lin, Bianca De Leo, Maik Obendorf, Muthuswamy Raveendran, Oliver M. Fischer, Cemsel Bafligil, Manman Guo, Ronald Alan Harris, Holger Hess-Stumpp, Alexis Laux-Biehlmann, Ernesto Lowy, Gerton Lunter, Jessica Malzahn, Nicholas G. Martin, Fernando O. Martinez, Sanjiv Manek, Stefanie Mesch, Grant W. Montgomery, Andrew P. Morris, Jens Nagel, Heather A. Simmons, Denise Brocklebank, Catherine Shang, Susan Treloar, Graham Wells, Christian M. Becker, Udo Oppermann, Thomas M. Zollner, Stephen H. Kennedy, Joseph W. Kemnitz, Jeffrey Rogers, Krina T. Zondervan. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Science Translational Medicine, 2021; 13 (608): eabd6469 DOI: 10.1126/scitranslmed.abd6469
The researchers performed genetic analyses of humans and rhesus macaques to identify a specific gene, NPSR1, that increases risk of suffering from endometriosis. The results reveal a potential new nonhormonal drug target that may lead to improved therapy. Their results are published in Science Translational Medicine.
The Oxford team, led by corresponding author Dr. Krina T. Zondervan, had previously found a genetic linkage to endometriosis on chromosome 7p13-15 by analyzing DNA from families containing at least three women diagnosed with endometriosis. The Baylor team, led by senior author Dr. Jeffrey Rogers, verified this genetic linkage in the DNA of rhesus monkeys with spontaneous endometriosis at the Wisconsin National Primate Research Center at the University of Wisconsin-Madison. This validation justified further research through in-depth sequencing analysis of the endometriosis families at Oxford, which narrowed down the genetic cause to rare variants in the NPSR1 gene. Most of the women carrying these rare variants had stage III/IV disease. The Baylor researchers similarly sequenced rhesus monkeys and again showed suggestive evidence also in this species. Finally, an Oxford study of more than 11,000 women, including patients with endometriosis and healthy women, identified a specific common variant in the NPSR1 gene also associated with stage III/IV endometriosis.
?This is one of the first examples of DNA sequencing in nonhuman primates to validate results in human studies and the first to make a significant impact on understanding the genetics of common, complex metabolic diseases,? said Rogers, associate professor at the Human Genome Sequencing Center at Baylor. ?The primate research really helped to provide confidence at each step of the genetic analysis in humans and gave us motivation to carry on chasing these particular genes.?
The insights revealed in this genetic analysis point to a potential new drug target. As part of this collaboration, researchers at Bayer, in scientific partnership with Oxford University, used an NPSR1 inhibitor to block protein signaling of that gene in cellular assays and then in mouse models of endometriosis. They found this treatment led to reduced inflammation and abdominal pain, thus identifying a target for future research in treating endometriosis.
?This is an exciting new development in our quest for new treatments of endometriosis, a debilitating and underrecognized disease affecting 190 million women worldwide. We need to do further research on the mechanism of action and the role of the genetic variants in modulation of the gene?s effects in specific tissues. However, we have a promising new nonhormonal target for further investigation and development that appears to address directly the inflammatory and pain components of the disease,? said Zondervan, head of the department of women?s and reproductive health, professor of reproductive and genomic epidemiology and co-director of the Endometriosis CaRe Centre at Oxford.
Dr. Thomas Tapmeier, now at Monash University, is co-corresponding author of the study.
We wish to thank the author of this short article for this outstanding material
";s:14:"date_timestamp";i:1635697274;}i:4;a:11:{s:5:"title";s:125:"Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming";s:4:"link";s:155:"https://moustachebrothers.com/reducing-tropical-cyclone-impacts-the-double-benefit-of-climate-protection-through-both-limiting-and-delaying-global-warming/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 15:04:08 +0000";s:8:"category";s:107:"Health And SciencebenefitClimatecyclonedelayingdoubleglobalimpactslimitingprotectionReducingtropicalwarming";s:4:"guid";s:36:"https://moustachebrothers.com/?p=717";s:11:"description";s:841:"Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming ? NovLink Home Mash R Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming We would like to give thanks to the writer of this write-up for this awesome content ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7174:"
Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming ? NovLink
We would like to give thanks to the writer of this write-up for this awesome content
";}s:7:"summary";s:841:"Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming ? NovLink Home Mash R Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming We would like to give thanks to the writer of this write-up for this awesome content ... Read more";s:12:"atom_content";s:7174:"
Reducing tropical cyclone impacts: The double benefit of climate protection through both limiting and delaying global warming ? NovLink
We would like to give thanks to the writer of this write-up for this awesome content
";s:14:"date_timestamp";i:1635692648;}i:5;a:11:{s:5:"title";s:99:"Scientists part of team that points to strong connection between climate change, plastics pollution";s:4:"link";s:129:"https://moustachebrothers.com/scientists-part-of-team-that-points-to-strong-connection-between-climate-change-plastics-pollution/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 13:47:12 +0000";s:8:"category";s:78:"Health And SciencechangeClimateconnectionplasticspollutionScientistsstrongteam";s:4:"guid";s:36:"https://moustachebrothers.com/?p=712";s:11:"description";s:745:"Scientists part of team that points to strong connection between climate change, plastics pollution ? NovLink Home Mash Q Scientists part of team that points to strong connection between climate change, plastics pollution We would like to thank the writer of this post for this amazing material Scientists part of team that points to strong ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6900:"
Scientists part of team that points to strong connection between climate change, plastics pollution ? NovLink
We would like to thank the writer of this post for this amazing material
";}s:7:"summary";s:745:"Scientists part of team that points to strong connection between climate change, plastics pollution ? NovLink Home Mash Q Scientists part of team that points to strong connection between climate change, plastics pollution We would like to thank the writer of this post for this amazing material Scientists part of team that points to strong ... Read more";s:12:"atom_content";s:6900:"
Scientists part of team that points to strong connection between climate change, plastics pollution ? NovLink
We would like to thank the writer of this post for this amazing material
";s:14:"date_timestamp";i:1635688032;}i:6;a:11:{s:5:"title";s:57:"Patta, Jacobs, Desalu and Tortu: ?That?s why we won gold?";s:4:"link";s:82:"https://moustachebrothers.com/patta-jacobs-desalu-and-tortu-thats-why-we-won-gold/";s:2:"dc";a:1:{s:7:"creator";s:12:"Paula Hooper";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 13:29:19 +0000";s:8:"category";s:35:"AthleticsDesalugoldJacobsPattaTortu";s:4:"guid";s:36:"https://moustachebrothers.com/?p=706";s:11:"description";s:662:"Great public success for the four heroes of the Olympics with the triumph in 4X100. Jacobs: “We are the opposite of Americans who hate each other …”. Patta: “I was calm, there was no audience, it seemed like a regional match” From our correspondent Valerio Piccioni @vaprap October 10 – TRENTO In Tokyo at one ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5098:"
Great public success for the four heroes of the Olympics with the triumph in 4X100. Jacobs: “We are the opposite of Americans who hate each other …”. Patta: “I was calm, there was no audience, it seemed like a regional match”
From our correspondent Valerio Piccioni
@vaprap
In Tokyo at one point they heard “Volare” and “Magical Nights” from the loudspeaker. This time, in the Santa Chiara Auditorium, an ?Italia, Italia? choir arrives, which was missing at the Olympics without an audience. The Sport Festival embraces the golden relay runners. And first of all Filippo Tortu, the comeback wizard, begins to explain that athletics is an individual sport, but “the relay is the maximum expression of a team”. What is striking is the naturalness with which Lorenzo Patta, Marcell Jacobs and Fausto Desalu, together with Tortu, talk to each other, deliver jokes that enchant the audience, tell in their own way that winning moment that will forever bind their stories. A bit like a musical group, it easily draws on a repertoire that has been tried a thousand times. Already the relay, linked by a real witness and an invisible one, the ability to feel within the same climb. “The opposite of Americans who hate each other,” says papal papal Jacobs.
Curve
?
The evening is a journey that does not want to reach the finish line. Because in the end, people “besiege” the Four Musketeers and don’t let them leave that easily. Lorenzo Patta is “as calm as he was then”, says Tortu. The almost rookie from Tokyo confirms: ?Fear? Absolutely not. I didn’t feel pressure, it seemed like a regional match for me, there was no public and I’m used to competing without an audience ?, says the Sardinian sprinter who admits, as a former football player, that his child idol has always been Francesco Totti. The line of the evening, however, is signed by Fausto Desalu, the fractionist number three. ?Why are you doing so well in the corners?? Ask Margherita Granbassi and Andrea Buongiovanni. He buzzes around the question and then shares: “In fact, if there were 100 meters in the curve, I would be the best!”. There is also a moment of great tenderness, we experience it when Granbassi asks Desalu why she defines sporting activity as ?a job?. Fausto replies that ?behind those 10 or 20 or 45 seconds there is a lot of commitment, no sacrifices, but sacrifices yes. And all this also means that you sweat, that you struggle, that sometimes you cry ?.
Fire
?
Cry. The one who did it the most in Tokyo was undoubtedly Filippo Tortu, ?I couldn’t stop doing it and they obviously made fun of me?. Before, however, there was more: a sensation. “We weren’t favorites, but we felt something, we felt we had more chances to win than to lose.” A sensation that multiplies during the last fraction. ?I was very lucid, I felt like a fire inside, pure competitive spirit?. Jacobs recounts how important Tortu was for his growth: ?It was a great stimulus for me and I took them many times from him. I really have to thank him ?. The last to leave the stage is Desalu, who is full of photos and would like to extend the evening even more: ?If you want, we’ll see you outside and let’s continue?. Another moment, yet another in these days, in which Trento embraces Tokyo and all that it has given us.
October 10, 2021 (change October 11, 2021 | 08:16)
";}s:7:"summary";s:662:"Great public success for the four heroes of the Olympics with the triumph in 4X100. Jacobs: “We are the opposite of Americans who hate each other …”. Patta: “I was calm, there was no audience, it seemed like a regional match” From our correspondent Valerio Piccioni @vaprap October 10 – TRENTO In Tokyo at one ... Read more";s:12:"atom_content";s:5098:"
Great public success for the four heroes of the Olympics with the triumph in 4X100. Jacobs: “We are the opposite of Americans who hate each other …”. Patta: “I was calm, there was no audience, it seemed like a regional match”
From our correspondent Valerio Piccioni
@vaprap
In Tokyo at one point they heard “Volare” and “Magical Nights” from the loudspeaker. This time, in the Santa Chiara Auditorium, an ?Italia, Italia? choir arrives, which was missing at the Olympics without an audience. The Sport Festival embraces the golden relay runners. And first of all Filippo Tortu, the comeback wizard, begins to explain that athletics is an individual sport, but “the relay is the maximum expression of a team”. What is striking is the naturalness with which Lorenzo Patta, Marcell Jacobs and Fausto Desalu, together with Tortu, talk to each other, deliver jokes that enchant the audience, tell in their own way that winning moment that will forever bind their stories. A bit like a musical group, it easily draws on a repertoire that has been tried a thousand times. Already the relay, linked by a real witness and an invisible one, the ability to feel within the same climb. “The opposite of Americans who hate each other,” says papal papal Jacobs.
Curve
?
The evening is a journey that does not want to reach the finish line. Because in the end, people “besiege” the Four Musketeers and don’t let them leave that easily. Lorenzo Patta is “as calm as he was then”, says Tortu. The almost rookie from Tokyo confirms: ?Fear? Absolutely not. I didn’t feel pressure, it seemed like a regional match for me, there was no public and I’m used to competing without an audience ?, says the Sardinian sprinter who admits, as a former football player, that his child idol has always been Francesco Totti. The line of the evening, however, is signed by Fausto Desalu, the fractionist number three. ?Why are you doing so well in the corners?? Ask Margherita Granbassi and Andrea Buongiovanni. He buzzes around the question and then shares: “In fact, if there were 100 meters in the curve, I would be the best!”. There is also a moment of great tenderness, we experience it when Granbassi asks Desalu why she defines sporting activity as ?a job?. Fausto replies that ?behind those 10 or 20 or 45 seconds there is a lot of commitment, no sacrifices, but sacrifices yes. And all this also means that you sweat, that you struggle, that sometimes you cry ?.
Fire
?
Cry. The one who did it the most in Tokyo was undoubtedly Filippo Tortu, ?I couldn’t stop doing it and they obviously made fun of me?. Before, however, there was more: a sensation. “We weren’t favorites, but we felt something, we felt we had more chances to win than to lose.” A sensation that multiplies during the last fraction. ?I was very lucid, I felt like a fire inside, pure competitive spirit?. Jacobs recounts how important Tortu was for his growth: ?It was a great stimulus for me and I took them many times from him. I really have to thank him ?. The last to leave the stage is Desalu, who is full of photos and would like to extend the evening even more: ?If you want, we’ll see you outside and let’s continue?. Another moment, yet another in these days, in which Trento embraces Tokyo and all that it has given us.
October 10, 2021 (change October 11, 2021 | 08:16)
";s:14:"date_timestamp";i:1635686959;}i:7;a:11:{s:5:"title";s:58:"Italy A, Marin avoids defeat: Spain folded 13-11 in Madrid";s:4:"link";s:87:"https://moustachebrothers.com/italy-a-marin-avoids-defeat-spain-folded-13-11-in-madrid/";s:2:"dc";a:1:{s:7:"creator";s:10:"Lance Kind";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 13:23:57 +0000";s:8:"category";s:44:"RugbyavoidsdefeatfoldedItalyMadridMarinSpain";s:4:"guid";s:36:"https://moustachebrothers.com/?p=700";s:11:"description";s:592:"A try and the opening kicks allow the Azzurri to beat Leon’s XV in a comeback, despite the goal by Bell and the yellows to Meloncello and Pettinelli had cornered the team entrusted to Troncon If the coach Kieran Crowley expected comforting indications from the match of the National A in Spain to draw men ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6061:"
A try and the opening kicks allow the Azzurri to beat Leon’s XV in a comeback, despite the goal by Bell and the yellows to Meloncello and Pettinelli had cornered the team entrusted to Troncon
If the coach Kieran Crowley expected comforting indications from the match of the National A in Spain to draw men and close the group of 33 players that he will have available for the Autumn Nations Series, he can only find himself disappointed. The Azzurri, entrusted to the leadership of Alessandro Troncon, in fact, in Madrid remedy a possible (sensational) fool by bending Leon’s XV 13-11 in comeback, but then suffering until the final whistle. Tomorrow, however, the Italian coach will inevitably have to sum up and try to understand who among the players who took to the field today will be able to enter the group with which Italy will face the challenges with All Blacks (November 6 in Rome), Argentina (13 in Treviso) and Uruguay (on the 20th in Parma).
Errors
?
It is not a good start for the Azzurri, too hasty and with an excess of aggression that borders on indiscipline, as when a dangerous attack fades for a forward. At the first attack, Spain passes instead: deep touch in the 22, Italy forced to defend itself incorrectly to avoid damage, but at the second infringement (which also costs Tommaso Meloncello a yellow card) Bautista Guemes decides to go for the goalposts and 12 ‘unlocks the result. Five minutes later Italy earns a good free kick, Leonardo Marin goes to find a nice touchout near 5 meters, but the Spanish defense disrupts the maul and causes a turnover. Spain retains possession from the scrum, but instead of kicking they play risky hand in their own 22, first opening to the right, then returning to the left, with great competence, climbing up to halfway. Climb also allowed by a bizarre arrangement of the blue defensive line. Spain takes risks and plays, but also has an individual technical competence that perhaps is not expected, plus Italy continues to grant penalties. And he still risks on 29 ‘, when after a touchdown in the 22 and another good possession, the dive into the ruck of the prop Jon Zabala shatters all the work. The extreme Ange Capuozzo emerges from the Italian mediocrity in the 31st minute, resolving a stalemate in attack with a perfect kick to find a deep touch. The forwards try to make meters, but are promptly rejected and when Marcello Violi tries to give speed, the backs are immediately attacked by the fast climb of the Spanish defense. A foul in the ruck by the Fijian flanker Ilaitia Gavidi allows Marin to find the deep penaltouche, but nothing good comes out of the throw-in, indeed a forward gives possession to the hosts, who immediately overturn the game front. At the end of the blue scrum, much higher, he earns two free kicks, on the second Marin goes into touch at 5 meters: the throw is perfect, the maul is well triggered, but Lorenzo Cannone has the bad idea of ??trying to do everything alone, he exits with the oval to launch himself towards the goal, he is tackled, remains isolated, commits held. Punishment for Spain and end of the first half.
Yellow and comeback
?
And it is not that the second half opens better: captain Pettinelli’s lightness, who sees himself overcome by the extreme John Bell and tries to remedy with a grip in the neck under the eyes of the referee, for an inevitable yellow card. And punctual at 7 ‘the goal arrives: after a scrum around 22 and a blue infraction, the Spaniards play on the advantage, Guemes grubber behind the defense, Meloncello is to cover but in falling back from the dive he incredibly loses the oval , on which Bell launches for a very easy destination. At this point, one might finally say, the blues shake up: at 52 ‘Marin shortens his place, then about ten minutes later, on an uncertain Spanish defense on the blue percussion, the blue number 10 sees a hole in front of him, he slips into it. and fly all alone under the poles. The opening realizes the transformation and then at 64 ‘slips another placed for 13-8. At 68 ‘Guemes answers him from the pitch for -2. Spain from a free-kick in the middle of the field goes to play for the touch, but the maul does not make way and the Azzurri conquer the turnover. There is evident fatigue among the men in the red jersey, but incomprehensibly the Blues prefer to kick and give the ball to their opponents: the choice turns out to be effective, because the defense is finally positive and with excellent pressure prevents the Spaniards from making the way. Indeed, we go to play a touch close to the 22 Spaniards, but after a long attack phase, Andrea Zambonin commits a foul in the breakdown, on the excellent Spanish defense, and goes back. The situation repeats itself just when you enter the last minute: possession regained, but kept blue and last possession to Spain, which tries to the limit, but a last forward on 10 meters condemns her to defeat.
October 30, 2021 (change October 30, 2021 | 19:11)
";}s:7:"summary";s:592:"A try and the opening kicks allow the Azzurri to beat Leon’s XV in a comeback, despite the goal by Bell and the yellows to Meloncello and Pettinelli had cornered the team entrusted to Troncon If the coach Kieran Crowley expected comforting indications from the match of the National A in Spain to draw men ... Read more";s:12:"atom_content";s:6061:"
A try and the opening kicks allow the Azzurri to beat Leon’s XV in a comeback, despite the goal by Bell and the yellows to Meloncello and Pettinelli had cornered the team entrusted to Troncon
If the coach Kieran Crowley expected comforting indications from the match of the National A in Spain to draw men and close the group of 33 players that he will have available for the Autumn Nations Series, he can only find himself disappointed. The Azzurri, entrusted to the leadership of Alessandro Troncon, in fact, in Madrid remedy a possible (sensational) fool by bending Leon’s XV 13-11 in comeback, but then suffering until the final whistle. Tomorrow, however, the Italian coach will inevitably have to sum up and try to understand who among the players who took to the field today will be able to enter the group with which Italy will face the challenges with All Blacks (November 6 in Rome), Argentina (13 in Treviso) and Uruguay (on the 20th in Parma).
Errors
?
It is not a good start for the Azzurri, too hasty and with an excess of aggression that borders on indiscipline, as when a dangerous attack fades for a forward. At the first attack, Spain passes instead: deep touch in the 22, Italy forced to defend itself incorrectly to avoid damage, but at the second infringement (which also costs Tommaso Meloncello a yellow card) Bautista Guemes decides to go for the goalposts and 12 ‘unlocks the result. Five minutes later Italy earns a good free kick, Leonardo Marin goes to find a nice touchout near 5 meters, but the Spanish defense disrupts the maul and causes a turnover. Spain retains possession from the scrum, but instead of kicking they play risky hand in their own 22, first opening to the right, then returning to the left, with great competence, climbing up to halfway. Climb also allowed by a bizarre arrangement of the blue defensive line. Spain takes risks and plays, but also has an individual technical competence that perhaps is not expected, plus Italy continues to grant penalties. And he still risks on 29 ‘, when after a touchdown in the 22 and another good possession, the dive into the ruck of the prop Jon Zabala shatters all the work. The extreme Ange Capuozzo emerges from the Italian mediocrity in the 31st minute, resolving a stalemate in attack with a perfect kick to find a deep touch. The forwards try to make meters, but are promptly rejected and when Marcello Violi tries to give speed, the backs are immediately attacked by the fast climb of the Spanish defense. A foul in the ruck by the Fijian flanker Ilaitia Gavidi allows Marin to find the deep penaltouche, but nothing good comes out of the throw-in, indeed a forward gives possession to the hosts, who immediately overturn the game front. At the end of the blue scrum, much higher, he earns two free kicks, on the second Marin goes into touch at 5 meters: the throw is perfect, the maul is well triggered, but Lorenzo Cannone has the bad idea of ??trying to do everything alone, he exits with the oval to launch himself towards the goal, he is tackled, remains isolated, commits held. Punishment for Spain and end of the first half.
Yellow and comeback
?
And it is not that the second half opens better: captain Pettinelli’s lightness, who sees himself overcome by the extreme John Bell and tries to remedy with a grip in the neck under the eyes of the referee, for an inevitable yellow card. And punctual at 7 ‘the goal arrives: after a scrum around 22 and a blue infraction, the Spaniards play on the advantage, Guemes grubber behind the defense, Meloncello is to cover but in falling back from the dive he incredibly loses the oval , on which Bell launches for a very easy destination. At this point, one might finally say, the blues shake up: at 52 ‘Marin shortens his place, then about ten minutes later, on an uncertain Spanish defense on the blue percussion, the blue number 10 sees a hole in front of him, he slips into it. and fly all alone under the poles. The opening realizes the transformation and then at 64 ‘slips another placed for 13-8. At 68 ‘Guemes answers him from the pitch for -2. Spain from a free-kick in the middle of the field goes to play for the touch, but the maul does not make way and the Azzurri conquer the turnover. There is evident fatigue among the men in the red jersey, but incomprehensibly the Blues prefer to kick and give the ball to their opponents: the choice turns out to be effective, because the defense is finally positive and with excellent pressure prevents the Spaniards from making the way. Indeed, we go to play a touch close to the 22 Spaniards, but after a long attack phase, Andrea Zambonin commits a foul in the breakdown, on the excellent Spanish defense, and goes back. The situation repeats itself just when you enter the last minute: possession regained, but kept blue and last possession to Spain, which tries to the limit, but a last forward on 10 meters condemns her to defeat.
October 30, 2021 (change October 30, 2021 | 19:11)
";s:14:"date_timestamp";i:1635686637;}i:8;a:11:{s:5:"title";s:78:"Assassin?s Creed Valhalla, Year 2 revealed: ?Isu language explains everything?";s:4:"link";s:104:"https://moustachebrothers.com/assassins-creed-valhalla-year-2-revealed-isu-language-explains-everything/";s:2:"dc";a:1:{s:7:"creator";s:11:"Toby Peters";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 13:22:42 +0000";s:8:"category";s:54:"SportAssassinsCreedexplainsIsulanguagerevealedValhalla";s:4:"guid";s:36:"https://moustachebrothers.com/?p=696";s:11:"description";s:724:"Discovering the future of Assassin’s Creed with Access the Animus, the most popular community born around the Ubisoft series. Paolo Sirio 24 October 2021 For the first time in the history of the series, Assassin’s Creed Valhalla will receive a Year 2, with more expansions than those launched after the main game’s release. A rather ... Read more";s:7:"content";a:1:{s:7:"encoded";s:12913:"
Discovering the future of Assassin’s Creed with Access the Animus, the most popular community born around the Ubisoft series.
Paolo Sirio
24 October 2021
For the first time in the history of the series, Assassin’s Creed Valhalla will receive a Year 2, with more expansions than those launched after the main game’s release. A rather curious circumstance, mainly dictated by the additional time required by the next chapter of the saga. Additional time needed for two reasons: the difficulties encountered in video game development during the pandemic and the ambitions placed in the project that will follow Valhalla, the still mysterious Assassin’s Creed Infinity. Infinity will be a significantly different title from Valhalla: the subject of rumors and then confirmed by Ubisoft itself, it will be an online platform that will contain multiple experiences, among which it is rumored that remakes of old chapters and, perhaps, a recovery of multiplayer will be found.
The experts –
But the times are not yet ripe and this is how Assassin’s Creed Valhalla comes back into play, which is about to extend its expected life cycle with a new, and unpredictable, round of content. We talked about it with the experts of Access the Animus, the most recognized and appreciated AC community in the world, with dozens of videos, very popular social accounts and many collaborations with Ubisoft itself. In particular, the commitment to decipher the Isu Language, an authentic language coined specifically for the Assassin’s Creed universe, has caused a stir among fans and insiders. The development house has invited them several times to its offices in Montreal and Quebec City (where the two leading teams in the production of the main games of the saga reside): the level of trust in them is so high that it has allowed them to participate in test of the titles in preview to be able to collect the opinion. Also for this reason, it becomes very interesting to find out what they think and what their speculations are (with some spoiler on the plot of Valhalla, you have been warned) on the first Year 2 in the history of the series.
Year 1 –
Before entering into the merits of Year 2, it is time to give a look at Year 1, which brought as a dowry, in addition to a series of free updates such as river raids, two paid expansions: The Wrath of the Druids and The Siege of Paris. According to the Access the Animus team, the DLCs are “decent”, with positive aspects concerning the settings (the first is set in Ireland) and the historical fidelity to the events of the time. However, four inconsistencies are evident, experts explain. First of all, both DLCs ?although historically set years after the last historical events of the main game, are considered as if they were happening in parallel with the first narrative arcs of the main game itself. So there are DLC characters who say they have talked or interacted with other characters who have actually been historically dead for some time ?.
Both in The Wrath of the Druids and in The Siege of Paris, then the enemies belong to two religious orders and not to the Templars, historical enemies of the saga and the Assassins, on the other hand, are practically absent in both contents. But it is the plot of the series in general that does not get too much hands on it: “the events related to the First Civilization”, the ancient race that preceded human beings as they are known today, in the language of the saga, “are also in this case limited in DLC “. Overall, the post-launch period of Assassin’s Creed Odyssey, the previous chapter, is considered superior especially in terms of paid expansions.
Assassin’s Creed Valhalla Year 2 –
That should change dramatically with the second year of Assassin’s Creed Valhalla, though. According to Access the Animus, it will be “the setting that will amaze, because we know, or at least we can hypothesize with a certain degree of confidence, that at least the first DLC of Year 2 will be mythological”. A hypothesis confirmed by this week’s leak about Dawn of Ragnarok, which seems to be set in the realm of the dwarves, Svartalfheim; after all, in June, Ubisoft had explained that “Eivor has not finished with Odin yet”.
?In fact, the two sequences of the main game of Valhalla with a mythological setting (Asgard and Jotunheim) have Odin as the main protagonist and this is due to the fact that Eivor is a reincarnation of the Isu Odin who lived about 75,000 years earlier. Thanks to this, Eivor is able to see some of the memories of the Isu Odin, but through the “mythological filter” with which as a child she learned about the Norse gods, and that is why we do not see the events related to Odin in a pure Isu setting, but in the aforementioned mythological settings ?, say the experts. “Self Eivor isn’t done with Odin yet, it will mean that Eivor will relive other memories of Odin in a similar way to what was done in the main game. They will be memories of the Isu / First Civilization era (and therefore will be of great interest to hardcore fans, always very attracted to these themes) but set in mythological locations “.
The portal –
In announcement trailer in Year 2 a mysterious portal is shown fleetingly. But what is it about? “It is not known at the moment what function it has in terms of plot, but for the purposes of the teaser the portal is important because there are two types of runes and writings on it,” they explain from ATA. ?Mainly what you see written on the portal is a type of language called Isu language, which in essence is the written language of the Isu / First Civilization (which therefore acts as a further clue to make it clear that the next DLC will show memories of the Isu era, but in a mythological sauce) ?.
The experts add that “at the top, in the center of the portal, there is another symbol that does not belong to the Isu language: it is a Nordic-Germanic rune called m-rune or Mannaz and which in several cases has been used to represent one of the nine realms of Norse mythology, that is Muspelheim, the land of flames and home of the fire giants and their leader Surtr. ?. The latest leaks seem to confirm that the first DLC of Year 2 should not be set in the kingdom of Muspelheim but a Svartalfheim; however, the plot should also feature Muspelheim and in particular an attack on the realm of the dwarves, and this may be enough to justify the rune on the portal.
The “translation” of Assassin’s Creed Valhalla –
On the portal, Access the Animus decrypted (by collecting compliments from Ubisoft) Isu language that anticipates an important role for Loki. ?Our translation of the Isu language on the portal is ‘Forsennato, what have you done?’, Where ‘The Forsennato’, within the plot of Valhalla is the name given to Odin by Loki and his partner Aletheia, during the Isu era. The hypothesis is that here it is Loki or his partner who is talking and that therefore in the next DLC Odin does something extremely serious or wrong. That said, it is possible that other Isu called Odin ‘The Forsennato’, so it may have been other characters who uttered this phrase ?.
The translation work required was massive and it’s interesting to take a look behind the scenes. “We passed from another Isu language phrase hidden in the teaser in none other than a repeated sound that is heard in its final and obtainable analyzing the spectrogram of this sound. This other sentence read: ‘What do you really understand? Would a blind man, trying to see, go mad? ‘ In this case, the sentence was also signed, by Loki: the ‘blind’ is in all probability Odin, notoriously blind in one eye in Norse mythology and equally blind in one eye also in the Isu plot of Valhalla. So, the hypothesis we extract from these sentences is that, sometime during Year 2, we may again be faced with some kind of confrontation between Loki and Odin ?.
The Isu language –
As experts say, the Isu language was created specifically by the developers of Assassin’s Creed and in particular by Antoine Henry, associate game director of Ubisoft Singapore. “Starting from the main game of Valhalla it was introduced to represent the written and spoken language of the First Civilization, the civilization of super-technological beings lived in the past that have permeated the saga since its creation” and, as a true language and own, contains “grammatical rules, words with roots and endings, grammatical cases that indicate the various complements, verbs with different endings to indicate the subject and the tense, adverbs “.
The Isu language is also referred to as a “progenitor language from which, within the lore of the saga, all the Indo-European languages, such as Latin, Greek and Sanskrit, which then led to the languages ??we speak now ?and the developers have even inserted common words between the languages ??in order to increase the credibility of their link. “The Isu language is also created as if it were an enigma to be solved: the developers have never published rules and it is up to the fans to understand and translate each new sentence released using those already translated previously”.
The fact that the intertwining of Isu and Norse mythology is more involved in the story suggests a closure with a bang for Assassin’s Creed Valhalla. After an interlocutory Year 1 and in view of the reopening of the games with the next Infinity, is just what it would take: both for the fans, whose passion is bearing ever more surprising fruits, as demonstrated by Access the Animus, and for the Ubisoft series.
";}s:7:"summary";s:724:"Discovering the future of Assassin’s Creed with Access the Animus, the most popular community born around the Ubisoft series. Paolo Sirio 24 October 2021 For the first time in the history of the series, Assassin’s Creed Valhalla will receive a Year 2, with more expansions than those launched after the main game’s release. A rather ... Read more";s:12:"atom_content";s:12913:"
Discovering the future of Assassin’s Creed with Access the Animus, the most popular community born around the Ubisoft series.
Paolo Sirio
24 October 2021
For the first time in the history of the series, Assassin’s Creed Valhalla will receive a Year 2, with more expansions than those launched after the main game’s release. A rather curious circumstance, mainly dictated by the additional time required by the next chapter of the saga. Additional time needed for two reasons: the difficulties encountered in video game development during the pandemic and the ambitions placed in the project that will follow Valhalla, the still mysterious Assassin’s Creed Infinity. Infinity will be a significantly different title from Valhalla: the subject of rumors and then confirmed by Ubisoft itself, it will be an online platform that will contain multiple experiences, among which it is rumored that remakes of old chapters and, perhaps, a recovery of multiplayer will be found.
The experts –
But the times are not yet ripe and this is how Assassin’s Creed Valhalla comes back into play, which is about to extend its expected life cycle with a new, and unpredictable, round of content. We talked about it with the experts of Access the Animus, the most recognized and appreciated AC community in the world, with dozens of videos, very popular social accounts and many collaborations with Ubisoft itself. In particular, the commitment to decipher the Isu Language, an authentic language coined specifically for the Assassin’s Creed universe, has caused a stir among fans and insiders. The development house has invited them several times to its offices in Montreal and Quebec City (where the two leading teams in the production of the main games of the saga reside): the level of trust in them is so high that it has allowed them to participate in test of the titles in preview to be able to collect the opinion. Also for this reason, it becomes very interesting to find out what they think and what their speculations are (with some spoiler on the plot of Valhalla, you have been warned) on the first Year 2 in the history of the series.
Year 1 –
Before entering into the merits of Year 2, it is time to give a look at Year 1, which brought as a dowry, in addition to a series of free updates such as river raids, two paid expansions: The Wrath of the Druids and The Siege of Paris. According to the Access the Animus team, the DLCs are “decent”, with positive aspects concerning the settings (the first is set in Ireland) and the historical fidelity to the events of the time. However, four inconsistencies are evident, experts explain. First of all, both DLCs ?although historically set years after the last historical events of the main game, are considered as if they were happening in parallel with the first narrative arcs of the main game itself. So there are DLC characters who say they have talked or interacted with other characters who have actually been historically dead for some time ?.
Both in The Wrath of the Druids and in The Siege of Paris, then the enemies belong to two religious orders and not to the Templars, historical enemies of the saga and the Assassins, on the other hand, are practically absent in both contents. But it is the plot of the series in general that does not get too much hands on it: “the events related to the First Civilization”, the ancient race that preceded human beings as they are known today, in the language of the saga, “are also in this case limited in DLC “. Overall, the post-launch period of Assassin’s Creed Odyssey, the previous chapter, is considered superior especially in terms of paid expansions.
Assassin’s Creed Valhalla Year 2 –
That should change dramatically with the second year of Assassin’s Creed Valhalla, though. According to Access the Animus, it will be “the setting that will amaze, because we know, or at least we can hypothesize with a certain degree of confidence, that at least the first DLC of Year 2 will be mythological”. A hypothesis confirmed by this week’s leak about Dawn of Ragnarok, which seems to be set in the realm of the dwarves, Svartalfheim; after all, in June, Ubisoft had explained that “Eivor has not finished with Odin yet”.
?In fact, the two sequences of the main game of Valhalla with a mythological setting (Asgard and Jotunheim) have Odin as the main protagonist and this is due to the fact that Eivor is a reincarnation of the Isu Odin who lived about 75,000 years earlier. Thanks to this, Eivor is able to see some of the memories of the Isu Odin, but through the “mythological filter” with which as a child she learned about the Norse gods, and that is why we do not see the events related to Odin in a pure Isu setting, but in the aforementioned mythological settings ?, say the experts. “Self Eivor isn’t done with Odin yet, it will mean that Eivor will relive other memories of Odin in a similar way to what was done in the main game. They will be memories of the Isu / First Civilization era (and therefore will be of great interest to hardcore fans, always very attracted to these themes) but set in mythological locations “.
The portal –
In announcement trailer in Year 2 a mysterious portal is shown fleetingly. But what is it about? “It is not known at the moment what function it has in terms of plot, but for the purposes of the teaser the portal is important because there are two types of runes and writings on it,” they explain from ATA. ?Mainly what you see written on the portal is a type of language called Isu language, which in essence is the written language of the Isu / First Civilization (which therefore acts as a further clue to make it clear that the next DLC will show memories of the Isu era, but in a mythological sauce) ?.
The experts add that “at the top, in the center of the portal, there is another symbol that does not belong to the Isu language: it is a Nordic-Germanic rune called m-rune or Mannaz and which in several cases has been used to represent one of the nine realms of Norse mythology, that is Muspelheim, the land of flames and home of the fire giants and their leader Surtr. ?. The latest leaks seem to confirm that the first DLC of Year 2 should not be set in the kingdom of Muspelheim but a Svartalfheim; however, the plot should also feature Muspelheim and in particular an attack on the realm of the dwarves, and this may be enough to justify the rune on the portal.
The “translation” of Assassin’s Creed Valhalla –
On the portal, Access the Animus decrypted (by collecting compliments from Ubisoft) Isu language that anticipates an important role for Loki. ?Our translation of the Isu language on the portal is ‘Forsennato, what have you done?’, Where ‘The Forsennato’, within the plot of Valhalla is the name given to Odin by Loki and his partner Aletheia, during the Isu era. The hypothesis is that here it is Loki or his partner who is talking and that therefore in the next DLC Odin does something extremely serious or wrong. That said, it is possible that other Isu called Odin ‘The Forsennato’, so it may have been other characters who uttered this phrase ?.
The translation work required was massive and it’s interesting to take a look behind the scenes. “We passed from another Isu language phrase hidden in the teaser in none other than a repeated sound that is heard in its final and obtainable analyzing the spectrogram of this sound. This other sentence read: ‘What do you really understand? Would a blind man, trying to see, go mad? ‘ In this case, the sentence was also signed, by Loki: the ‘blind’ is in all probability Odin, notoriously blind in one eye in Norse mythology and equally blind in one eye also in the Isu plot of Valhalla. So, the hypothesis we extract from these sentences is that, sometime during Year 2, we may again be faced with some kind of confrontation between Loki and Odin ?.
The Isu language –
As experts say, the Isu language was created specifically by the developers of Assassin’s Creed and in particular by Antoine Henry, associate game director of Ubisoft Singapore. “Starting from the main game of Valhalla it was introduced to represent the written and spoken language of the First Civilization, the civilization of super-technological beings lived in the past that have permeated the saga since its creation” and, as a true language and own, contains “grammatical rules, words with roots and endings, grammatical cases that indicate the various complements, verbs with different endings to indicate the subject and the tense, adverbs “.
The Isu language is also referred to as a “progenitor language from which, within the lore of the saga, all the Indo-European languages, such as Latin, Greek and Sanskrit, which then led to the languages ??we speak now ?and the developers have even inserted common words between the languages ??in order to increase the credibility of their link. “The Isu language is also created as if it were an enigma to be solved: the developers have never published rules and it is up to the fans to understand and translate each new sentence released using those already translated previously”.
The fact that the intertwining of Isu and Norse mythology is more involved in the story suggests a closure with a bang for Assassin’s Creed Valhalla. After an interlocutory Year 1 and in view of the reopening of the games with the next Infinity, is just what it would take: both for the fans, whose passion is bearing ever more surprising fruits, as demonstrated by Access the Animus, and for the Ubisoft series.
";s:14:"date_timestamp";i:1635686562;}i:9;a:11:{s:5:"title";s:64:"Allegri?s sticks (even to himself) and the 4 keys to start again";s:4:"link";s:92:"https://moustachebrothers.com/allegris-sticks-even-to-himself-and-the-4-keys-to-start-again/";s:2:"dc";a:1:{s:7:"creator";s:10:"Debby Kent";}s:7:"pubdate";s:31:"Sun, 31 Oct 2021 13:21:23 +0000";s:8:"category";s:27:"MotoringAllegrisStartsticks";s:4:"guid";s:36:"https://moustachebrothers.com/?p=692";s:11:"description";s:659:"Shame, silence, humility and determination: this is the recipe that the technician indicates the way out of the crisis The awareness of the reality of the dramatic ranking, far from expectations, pushes Allegri to ask his players for silence. Responsibilities are at all levels, and involve the coach first: it couldn’t be otherwise. But there ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4577:"
Shame, silence, humility and determination: this is the recipe that the technician indicates the way out of the crisis
The awareness of the reality of the dramatic ranking, far from expectations, pushes Allegri to ask his players for silence. Responsibilities are at all levels, and involve the coach first: it couldn’t be otherwise. But there are several significant passages in Max’s sentences after the defeat in Verona, which invite the Juventus reality to a precise reflection. Most of the solutions to today’s problems could already be found at home.
SHAME
?
?Right now you have to feel the shame of having only 15 points in the standings?, Allegri’s first whack. Who does not withdraw from criticism, but continues to evidently not see the team spirit he would like from his own. Equally significant were the words of Nedved, in support of the coach: ?For what we did on the pitch, we expected a few more points. Max also needs time, he has an advantage because he already knew the environment, but he has different players compared to two years ago ?.
ALL SHUT UP
?
The Juve coach calls everyone to maximum commitment in training and above all to a long period of reconstruction of the team spirit. “The only medicine you need is to work and keep quiet”. And again: “In a few months, when playing with another spirit we will be in a different position, maybe we will raise our heads”. Juve seemed to have found the right way thanks to the nine useful results up to San Siro with Inter, but they crumbled again in the last week against two small-medium formations, returning to the mistakes of the beginning of the season with Udinese and Empoli.
HUMILITY
?
That’s why Allegri’s sharpest sentence in the scorching post-match Bentegodi turns the spotlight on the attitude of his players. “There is no great team that wins without having respect for the opponent”. A strong call to humility, to make it clear that there is no advantage to be gained from wearing the Old Lady’s jersey without showing the competitive aggression necessary to face any team, whether it is more or less of little value. Max asks his team for a mental leap.
SOCCER, NOT FOIL
?
This is why the Juventus coach points out ?with the utmost respect, football is not foil. If you meet a team that has greater intensity, you have to put yourself on their level, on the spirit, on chasing, on running towards the opponent, on going after him ?. Hellas Verona closed the match by committing twenty-two fouls, Juve only eight: it is also from these details that a player is judged.
MID RANKING
?
Allegri is the highest paid manager in Serie A and has the team with the highest salary. He knows well, as all footballers know, that this Juve is not in the middle of the table. But without a bath of humility for everyone, without a process of self-criticism functional to reconstruct the priority identity, it will be difficult to get to the bottom of it. Here: thinking as a mid-table team, which does not have to race on the others but only on itself, and finding within it the desire to improve day after day, can be a good way to change the course. Now it is really necessary.
October 31, 2021 (change October 31, 2021 | 12:45 pm)
";}s:7:"summary";s:659:"Shame, silence, humility and determination: this is the recipe that the technician indicates the way out of the crisis The awareness of the reality of the dramatic ranking, far from expectations, pushes Allegri to ask his players for silence. Responsibilities are at all levels, and involve the coach first: it couldn’t be otherwise. But there ... Read more";s:12:"atom_content";s:4577:"
Shame, silence, humility and determination: this is the recipe that the technician indicates the way out of the crisis
The awareness of the reality of the dramatic ranking, far from expectations, pushes Allegri to ask his players for silence. Responsibilities are at all levels, and involve the coach first: it couldn’t be otherwise. But there are several significant passages in Max’s sentences after the defeat in Verona, which invite the Juventus reality to a precise reflection. Most of the solutions to today’s problems could already be found at home.
SHAME
?
?Right now you have to feel the shame of having only 15 points in the standings?, Allegri’s first whack. Who does not withdraw from criticism, but continues to evidently not see the team spirit he would like from his own. Equally significant were the words of Nedved, in support of the coach: ?For what we did on the pitch, we expected a few more points. Max also needs time, he has an advantage because he already knew the environment, but he has different players compared to two years ago ?.
ALL SHUT UP
?
The Juve coach calls everyone to maximum commitment in training and above all to a long period of reconstruction of the team spirit. “The only medicine you need is to work and keep quiet”. And again: “In a few months, when playing with another spirit we will be in a different position, maybe we will raise our heads”. Juve seemed to have found the right way thanks to the nine useful results up to San Siro with Inter, but they crumbled again in the last week against two small-medium formations, returning to the mistakes of the beginning of the season with Udinese and Empoli.
HUMILITY
?
That’s why Allegri’s sharpest sentence in the scorching post-match Bentegodi turns the spotlight on the attitude of his players. “There is no great team that wins without having respect for the opponent”. A strong call to humility, to make it clear that there is no advantage to be gained from wearing the Old Lady’s jersey without showing the competitive aggression necessary to face any team, whether it is more or less of little value. Max asks his team for a mental leap.
SOCCER, NOT FOIL
?
This is why the Juventus coach points out ?with the utmost respect, football is not foil. If you meet a team that has greater intensity, you have to put yourself on their level, on the spirit, on chasing, on running towards the opponent, on going after him ?. Hellas Verona closed the match by committing twenty-two fouls, Juve only eight: it is also from these details that a player is judged.
MID RANKING
?
Allegri is the highest paid manager in Serie A and has the team with the highest salary. He knows well, as all footballers know, that this Juve is not in the middle of the table. But without a bath of humility for everyone, without a process of self-criticism functional to reconstruct the priority identity, it will be difficult to get to the bottom of it. Here: thinking as a mid-table team, which does not have to race on the others but only on itself, and finding within it the desire to improve day after day, can be a good way to change the course. Now it is really necessary.
October 31, 2021 (change October 31, 2021 | 12:45 pm)