O:9:"MagpieRSS":24:{s:6:"parser";i:0;s:12:"current_item";a:0:{}s:5:"items";a:10:{i:0;a:11:{s:5:"title";s:100:"They ask for the presence of a coroner and body sniffing dog where they found Brian Laundrie?s items";s:4:"link";s:125:"https://travors.com/news/they-ask-for-the-presence-of-a-coroner-and-body-sniffing-dog-where-they-found-brian-laundries-items/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 17:33:45 +0000";s:8:"category";s:4:"News";s:4:"guid";s:125:"https://travors.com/news/they-ask-for-the-presence-of-a-coroner-and-body-sniffing-dog-where-they-found-brian-laundries-items/";s:11:"description";s:775:"Former FBI agent discusses search for Laundrie 1:45 (CNN) — The Sarasota County coroner and a body sniffing dog were called to a Florida park Wednesday where authorities found several items belonging to Brian Laundrie, Gabby Petito’s missing fiancé.Additional teams of first responders are arriving on the scene at Carlton Reserve as the search for ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5070:"
Former FBI agent discusses search for Laundrie 1:45
(CNN) — The Sarasota County coroner and a body sniffing dog were called to a Florida park Wednesday where authorities found several items belonging to Brian Laundrie, Gabby Petito’s missing fiancé. Additional teams of first responders are arriving on the scene at Carlton Reserve as the search for Brian Laundrie continues.
Laundrie’s parents, Chris and Roberta Laundrie, informed the FBI and the North Port Police Department Tuesday night that they intended to go to the park Wednesday morning to look for him, family attorney Steven Bertolino said. . Police met them there Wednesday morning, he said.
After a “brief search” at a courthouse Laundrie frequented, the family and law enforcement found “some items” that belonged to him, Bertolino said. He did not give further information on what or how many items were found.
Bertolino said police are now conducting a more thorough investigation of that area.
The Sarasota County Medical Examiner confirmed he was called to the scene, and the Pasco County Sheriff’s Office said there was also a body-sniffing dog and two observer dogs at the scene.
North Port Police declined to comment.
The discovery comes amid an exhaustive search for Laundrie’s whereabouts that has spanned over a month.
Could Brian Laundrie still be alive in a forest? 1:22
Almost two months ago, Petito, 22, disappeared while she and Laundrie, 23, were on a road trip through the western United States, documenting their travels on social media. Laundrie returned home to North Point, Florida, where they lived with her parents, without Petito on September 1.
After being unable to contact her, Petito’s family reported her missing 10 days later. Laundrie refused to cooperate with the investigation into his whereabouts, and soon after, he, too, disappeared, with his family telling investigators they believed he had gone to a nearby nature reserve.
Petito’s remains were found in a national forest in Wyoming on Sept. 19 near where the couple had last been seen together. Teton County Medical Examiner Dr. Brent Blue has ruled that he died from strangulation.
Laundrie has not been explicitly linked to Petito’s murder, but he is the subject of a federal arrest warrant for unauthorized use of someone else’s debit card in the days after Petito last spoke to his family.
Petito’s parents talk about Laundrie 2:18
CNN’s Madeleine Holcombe and Randi Kaye contributed to this report.
";}s:7:"summary";s:775:"Former FBI agent discusses search for Laundrie 1:45 (CNN) — The Sarasota County coroner and a body sniffing dog were called to a Florida park Wednesday where authorities found several items belonging to Brian Laundrie, Gabby Petito’s missing fiancé.Additional teams of first responders are arriving on the scene at Carlton Reserve as the search for ... Read more";s:12:"atom_content";s:5070:"
Former FBI agent discusses search for Laundrie 1:45
(CNN) — The Sarasota County coroner and a body sniffing dog were called to a Florida park Wednesday where authorities found several items belonging to Brian Laundrie, Gabby Petito’s missing fiancé. Additional teams of first responders are arriving on the scene at Carlton Reserve as the search for Brian Laundrie continues.
Laundrie’s parents, Chris and Roberta Laundrie, informed the FBI and the North Port Police Department Tuesday night that they intended to go to the park Wednesday morning to look for him, family attorney Steven Bertolino said. . Police met them there Wednesday morning, he said.
After a “brief search” at a courthouse Laundrie frequented, the family and law enforcement found “some items” that belonged to him, Bertolino said. He did not give further information on what or how many items were found.
Bertolino said police are now conducting a more thorough investigation of that area.
The Sarasota County Medical Examiner confirmed he was called to the scene, and the Pasco County Sheriff’s Office said there was also a body-sniffing dog and two observer dogs at the scene.
North Port Police declined to comment.
The discovery comes amid an exhaustive search for Laundrie’s whereabouts that has spanned over a month.
Could Brian Laundrie still be alive in a forest? 1:22
Almost two months ago, Petito, 22, disappeared while she and Laundrie, 23, were on a road trip through the western United States, documenting their travels on social media. Laundrie returned home to North Point, Florida, where they lived with her parents, without Petito on September 1.
After being unable to contact her, Petito’s family reported her missing 10 days later. Laundrie refused to cooperate with the investigation into his whereabouts, and soon after, he, too, disappeared, with his family telling investigators they believed he had gone to a nearby nature reserve.
Petito’s remains were found in a national forest in Wyoming on Sept. 19 near where the couple had last been seen together. Teton County Medical Examiner Dr. Brent Blue has ruled that he died from strangulation.
Laundrie has not been explicitly linked to Petito’s murder, but he is the subject of a federal arrest warrant for unauthorized use of someone else’s debit card in the days after Petito last spoke to his family.
Petito’s parents talk about Laundrie 2:18
CNN’s Madeleine Holcombe and Randi Kaye contributed to this report.
";s:14:"date_timestamp";i:1634751225;}i:1;a:11:{s:5:"title";s:50:"Genes play key role in exercise outcomes ? NovLink";s:4:"link";s:89:"https://travors.com/health-science-news/genes-play-key-role-in-exercise-outcomes-novlink/";s:2:"dc";a:1:{s:7:"creator";s:14:"stephen Henbie";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 16:55:44 +0000";s:8:"category";s:21:"Health & Science News";s:4:"guid";s:89:"https://travors.com/health-science-news/genes-play-key-role-in-exercise-outcomes-novlink/";s:11:"description";s:646:"Journal Reference: Henry C. Chung, Don R. Keiller, Justin D. Roberts, Dan A. Gordon. Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis. PLOS ONE, 2021; 16 (10): e0249501 DOI: 10.1371/journal.pone.0249501 The research, published in the journal PLOS ONE and led by experts from the Cambridge Centre ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4661:"
Journal Reference:
Henry C. Chung, Don R. Keiller, Justin D. Roberts, Dan A. Gordon. Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis. PLOS ONE, 2021; 16 (10): e0249501 DOI: 10.1371/journal.pone.0249501
The research, published in the journal PLOS ONE and led by experts from the Cambridge Centre for Sport & Exercise Sciences at Anglia Ruskin University (ARU) in England, found that up to 72% of the difference between people in performance outcome following a specific exercise can be due to genetic differences.
The scientists analysed results from 3,012 adults aged between 18-55 ? who had not previously taken part in exercise training ? to determine how our genes can affect three important types of physical exercise.
Muscle strength, cardiovascular fitness, and anaerobic power are all key factors in shaping an individual?s fitness, wellbeing, and quality of life, and all participants showed improvements following their exercise training, but to varying degrees, even when performing exactly the same exercise training.
By combining data from 24 separate studies, the researchers discovered that genetic differences are responsible for 72% of the variation in outcomes for people following identical exercises designed to improve muscle strength.
Meanwhile, genetic variations caused 44% of the differences seen following cardiovascular fitness exercises, measured through V?O2max testing, and 10% of the differences in outcomes following exercises to improve anaerobic power, which is key for movement and agility. The remaining variations are influenced by other factors such as diet and nutrition, recovery, and injuries.
Each gene possesses alleles, and the allele type can influence how effective that gene is. The researchers believe it is these alleles that cause people?s bodies to respond differently to the same exercises.
In total, the study identified 13 genes, and associated alleles, as being responsible for how well the body reacts to cardiovascular fitness, muscular strength, and anaerobic power exercises.
The researchers suggest that gene testing could allow exercises to be tailored so they are more effective for each individual, rather than generic exercise for all. This could benefit everyone from hospital patients undergoing rehabilitation to elite sportspeople.
Lead author Henry Chung, a Postgraduate Researcher at Anglia Ruskin University (ARU), said: ?We know that exercise is good for us, but we all improve at different rates, even when following identical training regimes. This means there are other factors at play.
?Our study found 13 genes that have a role in exercise outcomes, and we found that specific alleles contained within these genes are more suited to certain aspects of fitness. For example, with repetition exercises designed to boost muscular strength, genetic differences explained 72% of the variation in outcomes between people following the same training.
?Because everyone?s genetic make-up is different, our bodies respond slightly differently to the same exercises. Therefore, it should be possible to improve the effectiveness of an exercise regime by identifying someone?s genotype and then tailoring a specific training programme just for them.
?This could particularly benefit those who need to see improvements in a short period of time, such as hospital patients, or elite sportspeople, where marginal improvements could mean the difference between success and failure.?
";}s:7:"summary";s:646:"Journal Reference: Henry C. Chung, Don R. Keiller, Justin D. Roberts, Dan A. Gordon. Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis. PLOS ONE, 2021; 16 (10): e0249501 DOI: 10.1371/journal.pone.0249501 The research, published in the journal PLOS ONE and led by experts from the Cambridge Centre ... Read more";s:12:"atom_content";s:4661:"
Journal Reference:
Henry C. Chung, Don R. Keiller, Justin D. Roberts, Dan A. Gordon. Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis. PLOS ONE, 2021; 16 (10): e0249501 DOI: 10.1371/journal.pone.0249501
The research, published in the journal PLOS ONE and led by experts from the Cambridge Centre for Sport & Exercise Sciences at Anglia Ruskin University (ARU) in England, found that up to 72% of the difference between people in performance outcome following a specific exercise can be due to genetic differences.
The scientists analysed results from 3,012 adults aged between 18-55 ? who had not previously taken part in exercise training ? to determine how our genes can affect three important types of physical exercise.
Muscle strength, cardiovascular fitness, and anaerobic power are all key factors in shaping an individual?s fitness, wellbeing, and quality of life, and all participants showed improvements following their exercise training, but to varying degrees, even when performing exactly the same exercise training.
By combining data from 24 separate studies, the researchers discovered that genetic differences are responsible for 72% of the variation in outcomes for people following identical exercises designed to improve muscle strength.
Meanwhile, genetic variations caused 44% of the differences seen following cardiovascular fitness exercises, measured through V?O2max testing, and 10% of the differences in outcomes following exercises to improve anaerobic power, which is key for movement and agility. The remaining variations are influenced by other factors such as diet and nutrition, recovery, and injuries.
Each gene possesses alleles, and the allele type can influence how effective that gene is. The researchers believe it is these alleles that cause people?s bodies to respond differently to the same exercises.
In total, the study identified 13 genes, and associated alleles, as being responsible for how well the body reacts to cardiovascular fitness, muscular strength, and anaerobic power exercises.
The researchers suggest that gene testing could allow exercises to be tailored so they are more effective for each individual, rather than generic exercise for all. This could benefit everyone from hospital patients undergoing rehabilitation to elite sportspeople.
Lead author Henry Chung, a Postgraduate Researcher at Anglia Ruskin University (ARU), said: ?We know that exercise is good for us, but we all improve at different rates, even when following identical training regimes. This means there are other factors at play.
?Our study found 13 genes that have a role in exercise outcomes, and we found that specific alleles contained within these genes are more suited to certain aspects of fitness. For example, with repetition exercises designed to boost muscular strength, genetic differences explained 72% of the variation in outcomes between people following the same training.
?Because everyone?s genetic make-up is different, our bodies respond slightly differently to the same exercises. Therefore, it should be possible to improve the effectiveness of an exercise regime by identifying someone?s genotype and then tailoring a specific training programme just for them.
?This could particularly benefit those who need to see improvements in a short period of time, such as hospital patients, or elite sportspeople, where marginal improvements could mean the difference between success and failure.?
";s:14:"date_timestamp";i:1634748944;}i:2;a:11:{s:5:"title";s:122:"OAS approves, with 26 votes in favor, a resolution that demands an immediate solution to the crisis from the Ortega regime";s:4:"link";s:146:"https://travors.com/news/oas-approves-with-26-votes-in-favor-a-resolution-that-demands-an-immediate-solution-to-the-crisis-from-the-ortega-regime/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 16:50:46 +0000";s:8:"category";s:4:"News";s:4:"guid";s:146:"https://travors.com/news/oas-approves-with-26-votes-in-favor-a-resolution-that-demands-an-immediate-solution-to-the-crisis-from-the-ortega-regime/";s:11:"description";s:825:"The Permanent Council of the Organization of American States (OAS) discussed this Wednesday, October 20, the “situation of Nicaragua”, where the political climate of the country was addressed less than twenty days before the general voting of this country and without any vote in against and seven abstentions was approved with the support of 26 ... Read more";s:7:"content";a:1:{s:7:"encoded";s:10184:"
The Permanent Council of the Organization of American States (OAS) discussed this Wednesday, October 20, the “situation of Nicaragua”, where the political climate of the country was addressed less than twenty days before the general voting of this country and without any vote in against and seven abstentions was approved with the support of 26 countries.
The Government of Nicaragua announced a day before that it would not participate in this session, as a refusal to address “aspects that correspond solely and exclusively to the decision of Nicaraguan citizens,” it said in a written statement. Act that was confirmed at the beginning of the session on Wednesday.
A representative of Nicaragua read a document with the position of rejection of the Daniel Ortega regime to this meeting, in which he expressed, among other things, “that his sovereignty is not discussed” and confirmed that the Nicaraguan representation will not participate in the meeting. .
Resolution on “The Situation of Nicaragua”
In the session, Canada. The United States, Chile, Antigua and Barbuda, Costa Rica and Ecuador presented a Resolution entitled “the situation of Nicaragua”, in which they reiterate their call for “the immediate release of the presidential candidates and political prisoners.”
They also express “their grave concern over the circumstance that the Permanent Council’s attempts to commit the Government of Nicaragua to holding free and fair elections have been ignored.”
They ask to take note “with alarm of the deterioration of the situation of political rights and human rights in Nicaragua and of the commitment of the Nicaraguan Government to undermine the electoral process.”
They also vehemently urge the Government of Nicaragua to implement without delay the principles of the Inter-American Democratic Charter, as well as all internationally recognized standards, including agreed electoral reforms, with a view to holding free, fair and transparent elections as soon as possible. possible, under observation by the OAS and other credible international observation.
The Resolution asks “to adopt, if necessary, other actions in accordance with the Charter of the Organization of American States and the Inter-American Democratic Charter, including an assessment of the November 7 elections during the 51st General Assembly.”
The Resolution was approved by 26 countries in favor, none against, only Nicaragua absent and 7 countries abstained from voting.
The countries that voted in favor were: Belize, Brazil, Canada, Colombia, Costa Rica, Dominica, Ecuador, El Salvador, United States, Grenada, Guatemala, Guyana, Haiti, Jamaica, Panama, Paraguay, Peru, Dominican Republic, San Cristóbal and Nieves, Saint Lucia, Suriname, Trinidad and Tobago, Uruguay, Venezuela, Antigua and Barbuda, Bahamas.
The countries that abstained were: Barbados, Bolivia, Honduras, Mexico, Guatemala, Saint Vincent and the Grenadines, and Argentina.
The draft Order of the Day for the ordinary session, which was held in virtual mode, placed the issue of Nicaragua as the second agenda item.
The minute by minute of the session
9:33 am The Secretary General of the OAS, Luis Almagro, recalled Nicaragua’s commitments to the Democratic Charter, including holding free and fair elections, but said that Nicaragua decided the path of authoritarianism. Almagro said that Nicaragua has to hold free and fair elections and has to release political prisoners.
09:29 am United States delegate affirms that the elections are a sham and calls for the release of political prisoners. He warned that his country will continue to use all diplomatic tools to hold those who are at the forefront of the country’s drift accountable. The delegate said that the United States is not invoking the Inter-American Democratic Charter, but the Nicaraguan government itself with its actions. He said that Nicaragua has made the Democratic Charter a “wet paper”:
09:25 am Delegate from Paraguay expresses her support for the resolution and declares that more actions have been lacking from the eastern organizations.
09:13 am Delegate from Uruguay makes a strong criticism of the countries that say that declaring themselves on the situation in Nicaragua is interference. He complains to those countries that if they do not see the case of Sergio Ramírez, who is in exile due to the accusations made against him within that country.
09:10 am Delegate from Argentina said that he cannot agree with that resolution because it represents interference in the internal affairs of a country.
09:07 am Delegate from Bolivia does not share the Resolution and calls the actions of the OAS disastrous when they published a report on the last elections in this country.
09:05 am Delegate from Suriname advocated for the defense of all peaceful possibilities to resolve the crisis in Nicaragua.
09:00 am Delegation of Costa Rica defends the approved Resolution, calls for respect for human rights, institutions and democracy in Nicaragua.
8:55 am Representative of Canada asks for the floor, to contextualize the political situation in Nicaragua and ask for free and fair elections to be held.
08:54 am. The delegation of Ecuador asks for the floor. 8:52 am Mexico asks for the floor, to express its concern about the isolation to which Nicaragua is being subjected and to say that this means the failure of the organization. He reaffirmed his desire for dialogue.
8:51 am 26 votes in favor, none against, 7 abstentions, one delegation absent.
08:33 am Voting begins.
Barbados: Abstains
Belize: In favor
Bolivia: Abstention and reserves the right to justify it.
Brazil: In favor
Canada: In favor
Colombia: In favor
Costa Rica: In favor
Dominica: A favor
Ecuador: In favor
El Salvador: In favor
United States: In favor
Granada: In favor
Guatemala: Abtention
Guyana: A favor
Haiti: A favor
Honduras: Abstention
Jamaica In favor
Mexico: Abstention
Nicaragua: Absent
Panama: In favor
Paraguay: In favor
Peru: In favor
Dominican Republic: In favor
Saint Kitts and Nevis: In favor
Saint Lucia: In favor
Saint Vincent and the Grenadines: Abstains
Suriname: A favor
Trinidad and Tobago: In favor
Uruguay: In favor
Venezuela: In favor
Antigua and Barbuda: In favor
Argentina: Abstention
Bahamas: A favor
8:26 am The Ambassador of Antigua and Barbuda asks for the floor. Robert Sanders rejected the allegations of the Nicaraguan delegation that this session is violating the sovereignty of that country and reminded him that they signed an agreement with this organization. He reiterated that the draft resolution is not a condemnation, but that they are asking him to do the right thing.
8:23 am The representative of Belize spoke to support the resolution.
8:20 am The Ambassador of Chile was the first to speak, to present the draft Resolution supported by Canada, Antigua and Barbuda, Chile, Costa Rica, Ecuador, the United States, Paraguay and Uruguay.
Draft Resolution:
Reiterate its call for the immediate release of the presidential candidates and political prisoners.
Express its grave concern over the circumstance that the Permanent Council’s attempts to commit the Government of Nicaragua to holding free and fair elections have been ignored.
To note with alarm the deterioration of the situation of political rights and human rights in Nicaragua and the commitment of the Government of Nicaragua to undermine the electoral process.
To vehemently urge the Government of Nicaragua to implement without delay the principles of the Inter-American Democratic Charter, as well as all internationally recognized standards, including the agreed electoral reforms, with a view to holding free, fair and transparent elections as soon as possible possible, under OAS observation and other credible international observation.
Adopt, if necessary, other actions in accordance with the Charter of the Organization of American States and the Inter-American Democratic Charter, including an assessment of the November 7 elections during the 51st General Assembly.
08:15 am The Nicaraguan delegation intervenes to establish the position of rejection of the Daniel Ortega regime.
08:14 am Discussion begins on the topic “The situation in Nicaragua”
";}s:7:"summary";s:825:"The Permanent Council of the Organization of American States (OAS) discussed this Wednesday, October 20, the “situation of Nicaragua”, where the political climate of the country was addressed less than twenty days before the general voting of this country and without any vote in against and seven abstentions was approved with the support of 26 ... Read more";s:12:"atom_content";s:10184:"
The Permanent Council of the Organization of American States (OAS) discussed this Wednesday, October 20, the “situation of Nicaragua”, where the political climate of the country was addressed less than twenty days before the general voting of this country and without any vote in against and seven abstentions was approved with the support of 26 countries.
The Government of Nicaragua announced a day before that it would not participate in this session, as a refusal to address “aspects that correspond solely and exclusively to the decision of Nicaraguan citizens,” it said in a written statement. Act that was confirmed at the beginning of the session on Wednesday.
A representative of Nicaragua read a document with the position of rejection of the Daniel Ortega regime to this meeting, in which he expressed, among other things, “that his sovereignty is not discussed” and confirmed that the Nicaraguan representation will not participate in the meeting. .
Resolution on “The Situation of Nicaragua”
In the session, Canada. The United States, Chile, Antigua and Barbuda, Costa Rica and Ecuador presented a Resolution entitled “the situation of Nicaragua”, in which they reiterate their call for “the immediate release of the presidential candidates and political prisoners.”
They also express “their grave concern over the circumstance that the Permanent Council’s attempts to commit the Government of Nicaragua to holding free and fair elections have been ignored.”
They ask to take note “with alarm of the deterioration of the situation of political rights and human rights in Nicaragua and of the commitment of the Nicaraguan Government to undermine the electoral process.”
They also vehemently urge the Government of Nicaragua to implement without delay the principles of the Inter-American Democratic Charter, as well as all internationally recognized standards, including agreed electoral reforms, with a view to holding free, fair and transparent elections as soon as possible. possible, under observation by the OAS and other credible international observation.
The Resolution asks “to adopt, if necessary, other actions in accordance with the Charter of the Organization of American States and the Inter-American Democratic Charter, including an assessment of the November 7 elections during the 51st General Assembly.”
The Resolution was approved by 26 countries in favor, none against, only Nicaragua absent and 7 countries abstained from voting.
The countries that voted in favor were: Belize, Brazil, Canada, Colombia, Costa Rica, Dominica, Ecuador, El Salvador, United States, Grenada, Guatemala, Guyana, Haiti, Jamaica, Panama, Paraguay, Peru, Dominican Republic, San Cristóbal and Nieves, Saint Lucia, Suriname, Trinidad and Tobago, Uruguay, Venezuela, Antigua and Barbuda, Bahamas.
The countries that abstained were: Barbados, Bolivia, Honduras, Mexico, Guatemala, Saint Vincent and the Grenadines, and Argentina.
The draft Order of the Day for the ordinary session, which was held in virtual mode, placed the issue of Nicaragua as the second agenda item.
The minute by minute of the session
9:33 am The Secretary General of the OAS, Luis Almagro, recalled Nicaragua’s commitments to the Democratic Charter, including holding free and fair elections, but said that Nicaragua decided the path of authoritarianism. Almagro said that Nicaragua has to hold free and fair elections and has to release political prisoners.
09:29 am United States delegate affirms that the elections are a sham and calls for the release of political prisoners. He warned that his country will continue to use all diplomatic tools to hold those who are at the forefront of the country’s drift accountable. The delegate said that the United States is not invoking the Inter-American Democratic Charter, but the Nicaraguan government itself with its actions. He said that Nicaragua has made the Democratic Charter a “wet paper”:
09:25 am Delegate from Paraguay expresses her support for the resolution and declares that more actions have been lacking from the eastern organizations.
09:13 am Delegate from Uruguay makes a strong criticism of the countries that say that declaring themselves on the situation in Nicaragua is interference. He complains to those countries that if they do not see the case of Sergio Ramírez, who is in exile due to the accusations made against him within that country.
09:10 am Delegate from Argentina said that he cannot agree with that resolution because it represents interference in the internal affairs of a country.
09:07 am Delegate from Bolivia does not share the Resolution and calls the actions of the OAS disastrous when they published a report on the last elections in this country.
09:05 am Delegate from Suriname advocated for the defense of all peaceful possibilities to resolve the crisis in Nicaragua.
09:00 am Delegation of Costa Rica defends the approved Resolution, calls for respect for human rights, institutions and democracy in Nicaragua.
8:55 am Representative of Canada asks for the floor, to contextualize the political situation in Nicaragua and ask for free and fair elections to be held.
08:54 am. The delegation of Ecuador asks for the floor. 8:52 am Mexico asks for the floor, to express its concern about the isolation to which Nicaragua is being subjected and to say that this means the failure of the organization. He reaffirmed his desire for dialogue.
8:51 am 26 votes in favor, none against, 7 abstentions, one delegation absent.
08:33 am Voting begins.
Barbados: Abstains
Belize: In favor
Bolivia: Abstention and reserves the right to justify it.
Brazil: In favor
Canada: In favor
Colombia: In favor
Costa Rica: In favor
Dominica: A favor
Ecuador: In favor
El Salvador: In favor
United States: In favor
Granada: In favor
Guatemala: Abtention
Guyana: A favor
Haiti: A favor
Honduras: Abstention
Jamaica In favor
Mexico: Abstention
Nicaragua: Absent
Panama: In favor
Paraguay: In favor
Peru: In favor
Dominican Republic: In favor
Saint Kitts and Nevis: In favor
Saint Lucia: In favor
Saint Vincent and the Grenadines: Abstains
Suriname: A favor
Trinidad and Tobago: In favor
Uruguay: In favor
Venezuela: In favor
Antigua and Barbuda: In favor
Argentina: Abstention
Bahamas: A favor
8:26 am The Ambassador of Antigua and Barbuda asks for the floor. Robert Sanders rejected the allegations of the Nicaraguan delegation that this session is violating the sovereignty of that country and reminded him that they signed an agreement with this organization. He reiterated that the draft resolution is not a condemnation, but that they are asking him to do the right thing.
8:23 am The representative of Belize spoke to support the resolution.
8:20 am The Ambassador of Chile was the first to speak, to present the draft Resolution supported by Canada, Antigua and Barbuda, Chile, Costa Rica, Ecuador, the United States, Paraguay and Uruguay.
Draft Resolution:
Reiterate its call for the immediate release of the presidential candidates and political prisoners.
Express its grave concern over the circumstance that the Permanent Council’s attempts to commit the Government of Nicaragua to holding free and fair elections have been ignored.
To note with alarm the deterioration of the situation of political rights and human rights in Nicaragua and the commitment of the Government of Nicaragua to undermine the electoral process.
To vehemently urge the Government of Nicaragua to implement without delay the principles of the Inter-American Democratic Charter, as well as all internationally recognized standards, including the agreed electoral reforms, with a view to holding free, fair and transparent elections as soon as possible possible, under OAS observation and other credible international observation.
Adopt, if necessary, other actions in accordance with the Charter of the Organization of American States and the Inter-American Democratic Charter, including an assessment of the November 7 elections during the 51st General Assembly.
08:15 am The Nicaraguan delegation intervenes to establish the position of rejection of the Daniel Ortega regime.
08:14 am Discussion begins on the topic “The situation in Nicaragua”
";s:14:"date_timestamp";i:1634748646;}i:3;a:11:{s:5:"title";s:61:"Newcastle begins renovation with the departure of Steve Bruce";s:4:"link";s:87:"https://travors.com/news/newcastle-begins-renovation-with-the-departure-of-steve-bruce/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 16:07:38 +0000";s:8:"category";s:4:"News";s:4:"guid";s:87:"https://travors.com/news/newcastle-begins-renovation-with-the-departure-of-steve-bruce/";s:11:"description";s:606:"With the team in penultimate place in the Premier League, Newcastle decided to dispense with the services of manager Steve Bruce, in the first major decision of the Saudi fund The Newcastle United confirmed the departure of Steve Bruce as a team manager, which is the first major decision of the Saudi fund since buying ... Read more";s:7:"content";a:1:{s:7:"encoded";s:3410:"
With the team in penultimate place in the Premier League, Newcastle decided to dispense with the services of manager Steve Bruce, in the first major decision of the Saudi fund
The Newcastle United confirmed the departure of Steve Bruce as a team manager, which is the first major decision of the Saudi fund since buying the club.
“Newcastle can confirm Steve Bruce leaves office by mutual agreement“said the English team in a statement, confirming the departure of Bruce after more than two years in office, in which he finished thirteenth and twelfth in the Premier League.
However, right now the team is penultimate with three points after eight days, which has precipitated the departure of Bruce, who last weekend, in the defeat against him Tottenham Hotspur He completed his 1,000th meeting of his career.
“I am very grateful to Newcastle for giving me the opportunity to lead this club. I would like to thank my coaching staff, the players and all the workers for this time for their great effort. There have been ups and downs, but they have always given their all and they have to be proud, “explained Bruce.
“This is a club with a great mass of fans and I hope that the new owners can take it forward and position it where we all want it to be,” he added.
";}s:7:"summary";s:606:"With the team in penultimate place in the Premier League, Newcastle decided to dispense with the services of manager Steve Bruce, in the first major decision of the Saudi fund The Newcastle United confirmed the departure of Steve Bruce as a team manager, which is the first major decision of the Saudi fund since buying ... Read more";s:12:"atom_content";s:3410:"
With the team in penultimate place in the Premier League, Newcastle decided to dispense with the services of manager Steve Bruce, in the first major decision of the Saudi fund
The Newcastle United confirmed the departure of Steve Bruce as a team manager, which is the first major decision of the Saudi fund since buying the club.
“Newcastle can confirm Steve Bruce leaves office by mutual agreement“said the English team in a statement, confirming the departure of Bruce after more than two years in office, in which he finished thirteenth and twelfth in the Premier League.
However, right now the team is penultimate with three points after eight days, which has precipitated the departure of Bruce, who last weekend, in the defeat against him Tottenham Hotspur He completed his 1,000th meeting of his career.
“I am very grateful to Newcastle for giving me the opportunity to lead this club. I would like to thank my coaching staff, the players and all the workers for this time for their great effort. There have been ups and downs, but they have always given their all and they have to be proud, “explained Bruce.
“This is a club with a great mass of fans and I hope that the new owners can take it forward and position it where we all want it to be,” he added.
";s:14:"date_timestamp";i:1634746058;}i:4;a:11:{s:5:"title";s:44:"Pollution?s impact on child health ? NovLink";s:4:"link";s:82:"https://travors.com/health-science-news/pollutions-impact-on-child-health-novlink/";s:2:"dc";a:1:{s:7:"creator";s:14:"stephen Henbie";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 15:54:55 +0000";s:8:"category";s:21:"Health & Science News";s:4:"guid";s:82:"https://travors.com/health-science-news/pollutions-impact-on-child-health-novlink/";s:11:"description";s:668:"Journal Reference: Allison R. Sherris, Bilkis A. Begum, Michael Baiocchi, Doli Goswami, Philip K. Hopke, W. Abdullah Brooks, Stephen P. Luby. Associations between ambient fine particulate matter and child respiratory infection: The role of particulate matter source composition in Dhaka, Bangladesh. Environmental Pollution, 2021; 290: 118073 DOI: 10.1016/j.envpol.2021.118073 A Stanford-led study reveals a link between ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6627:"
Journal Reference:
Allison R. Sherris, Bilkis A. Begum, Michael Baiocchi, Doli Goswami, Philip K. Hopke, W. Abdullah Brooks, Stephen P. Luby. Associations between ambient fine particulate matter and child respiratory infection: The role of particulate matter source composition in Dhaka, Bangladesh. Environmental Pollution, 2021; 290: 118073 DOI: 10.1016/j.envpol.2021.118073
A Stanford-led study reveals a link between tiny airborne particles and child health in South Asia, a region beset with air pollution and more than 40 percent of global pneumonia cases. The analysis, published in Environmental Pollution, estimates the effect of increased particulate on child pneumonia hospitalizations is about twice as much as previously thought, and indicates a particular industry may play an outsized role in the problem.
The findings could help public health officials and policymakers better target emissions reduction programs to improve child health.
?Everybody wants to protect kids? health,? said study lead author Allison Sherris, a postdoctoral research fellow in Earth system science at Stanford?s School of Earth, Energy & Environmental Sciences. ?Now, we have evidence of a clear health benefit to children from reducing ambient PM2.5 emissions in Dhaka.?
For many of the 21 million residents of Dhaka, Bangladesh ? the study?s focus area ? air pollution is an all-too-regular part of life, especially in winter, when coal-burning brick kilns around the city operate. Of special concern is PM2.5, airborne particles 2.5 micrometers wide or smaller. The larger of these particles are about one-thirtieth the width of a human hair, small enough to inhale deep into the lungs.
Once inside the lungs, these particles can cause inflammation and impair the body?s ability to fight infection. But particles from different sources can have different shape, size and chemical composition, and it?s not clear what specific components of PM2.5 might be most harmful.
Few studies have evaluated the health effects of PM2.5 in infants and young children, especially in low-income countries where children are more than 60 times as likely to die from air pollution exposure as children in high-income countries, according to the World Bank. Among studies that have, most focused on the indoor environment, where the use of biomass-burning cookstoves has been associated with child respiratory infection.
?Specifying the impact of industry-generated air pollution on child health provides compelling evidence to support interventions to reduce pollution,? said study senior author Stephen Luby, a professor of infectious diseases at Stanford University. ?This is often more salient to politicians than the marginal contribution of emissions to global climate change.?
Sherris, Luby and their colleagues analyzed long-term PM2.5 monitoring data alongside community health surveillance of respiratory infections from the Atomic Energy Centre, Dhaka, and the International Centre for Diarrhoeal Disease Research, Bangladesh. They found pneumonia incidence among children under 5 increased by 3.2 percent for every PM2.5 increase of 10 micrograms per cubic meter of air ? a standard measure in air pollution analysis.
The mean PM2.5 level in Dhaka was on average over three times higher than the World Health Organization standard. The association between air pollution and child pneumonia suggests that air pollution is a major contributor to the leading cause of child death in Bangladesh and across South Asia.
That difference equates to more than 200,000 additional child pneumonia cases in Bangladesh each year, and nearly two million additional cases across South Asia. The increase is also approximately double similar prior estimates of pneumonia hospitalizations associated with increased PM2.5 and about 10 times more than such estimates for outpatient visits.
The difference from previous findings may reflect the young age of the study population ? most children in the study were two or younger ? the source composition of particulate matter in Dhaka, and the fact that the study included nearly all community infection cases, rather than just focusing on cases that made it to clinics and hospitals.
Prior studies by researchers at the Atomic Energy Centre, Dhaka found that biomass burning contributed the most to outdoor PM2.5 levels, followed by brick kiln emissions and soil dust. However, on days when brick kilns contributed a heavier than-usual amount of PM2.5 to the mix of bad air, the link between PM2.5 and child pneumonia was stronger.
The findings are among the first evidence that communities and policymakers can point to that suggests a measurable impact of brick kilns on child health. Considering 9 out of 10 people live in areas with air pollution exceeding World Health Organization guidelines, further investigation into whether particles from brick kilns and other sources have different health impacts could inform health and environmental interventions around the world. Luby leads a collaboration among public health experts, industry stakeholders, technology consultants and government agencies to improve the industry. He received funding for related work focused on brick kilns and other industries, funded by the Sustainability Initiative that gave rise to Stanford?s new school focused on climate and sustainability.
?We?re still only looking at a small slice of the potential health outcomes that might be linked to this kind of air pollution, and we still lack perfect measurements of exposure to it,? said Sherris. ?The true health burden is likely much greater.
";}s:7:"summary";s:668:"Journal Reference: Allison R. Sherris, Bilkis A. Begum, Michael Baiocchi, Doli Goswami, Philip K. Hopke, W. Abdullah Brooks, Stephen P. Luby. Associations between ambient fine particulate matter and child respiratory infection: The role of particulate matter source composition in Dhaka, Bangladesh. Environmental Pollution, 2021; 290: 118073 DOI: 10.1016/j.envpol.2021.118073 A Stanford-led study reveals a link between ... Read more";s:12:"atom_content";s:6627:"
Journal Reference:
Allison R. Sherris, Bilkis A. Begum, Michael Baiocchi, Doli Goswami, Philip K. Hopke, W. Abdullah Brooks, Stephen P. Luby. Associations between ambient fine particulate matter and child respiratory infection: The role of particulate matter source composition in Dhaka, Bangladesh. Environmental Pollution, 2021; 290: 118073 DOI: 10.1016/j.envpol.2021.118073
A Stanford-led study reveals a link between tiny airborne particles and child health in South Asia, a region beset with air pollution and more than 40 percent of global pneumonia cases. The analysis, published in Environmental Pollution, estimates the effect of increased particulate on child pneumonia hospitalizations is about twice as much as previously thought, and indicates a particular industry may play an outsized role in the problem.
The findings could help public health officials and policymakers better target emissions reduction programs to improve child health.
?Everybody wants to protect kids? health,? said study lead author Allison Sherris, a postdoctoral research fellow in Earth system science at Stanford?s School of Earth, Energy & Environmental Sciences. ?Now, we have evidence of a clear health benefit to children from reducing ambient PM2.5 emissions in Dhaka.?
For many of the 21 million residents of Dhaka, Bangladesh ? the study?s focus area ? air pollution is an all-too-regular part of life, especially in winter, when coal-burning brick kilns around the city operate. Of special concern is PM2.5, airborne particles 2.5 micrometers wide or smaller. The larger of these particles are about one-thirtieth the width of a human hair, small enough to inhale deep into the lungs.
Once inside the lungs, these particles can cause inflammation and impair the body?s ability to fight infection. But particles from different sources can have different shape, size and chemical composition, and it?s not clear what specific components of PM2.5 might be most harmful.
Few studies have evaluated the health effects of PM2.5 in infants and young children, especially in low-income countries where children are more than 60 times as likely to die from air pollution exposure as children in high-income countries, according to the World Bank. Among studies that have, most focused on the indoor environment, where the use of biomass-burning cookstoves has been associated with child respiratory infection.
?Specifying the impact of industry-generated air pollution on child health provides compelling evidence to support interventions to reduce pollution,? said study senior author Stephen Luby, a professor of infectious diseases at Stanford University. ?This is often more salient to politicians than the marginal contribution of emissions to global climate change.?
Sherris, Luby and their colleagues analyzed long-term PM2.5 monitoring data alongside community health surveillance of respiratory infections from the Atomic Energy Centre, Dhaka, and the International Centre for Diarrhoeal Disease Research, Bangladesh. They found pneumonia incidence among children under 5 increased by 3.2 percent for every PM2.5 increase of 10 micrograms per cubic meter of air ? a standard measure in air pollution analysis.
The mean PM2.5 level in Dhaka was on average over three times higher than the World Health Organization standard. The association between air pollution and child pneumonia suggests that air pollution is a major contributor to the leading cause of child death in Bangladesh and across South Asia.
That difference equates to more than 200,000 additional child pneumonia cases in Bangladesh each year, and nearly two million additional cases across South Asia. The increase is also approximately double similar prior estimates of pneumonia hospitalizations associated with increased PM2.5 and about 10 times more than such estimates for outpatient visits.
The difference from previous findings may reflect the young age of the study population ? most children in the study were two or younger ? the source composition of particulate matter in Dhaka, and the fact that the study included nearly all community infection cases, rather than just focusing on cases that made it to clinics and hospitals.
Prior studies by researchers at the Atomic Energy Centre, Dhaka found that biomass burning contributed the most to outdoor PM2.5 levels, followed by brick kiln emissions and soil dust. However, on days when brick kilns contributed a heavier than-usual amount of PM2.5 to the mix of bad air, the link between PM2.5 and child pneumonia was stronger.
The findings are among the first evidence that communities and policymakers can point to that suggests a measurable impact of brick kilns on child health. Considering 9 out of 10 people live in areas with air pollution exceeding World Health Organization guidelines, further investigation into whether particles from brick kilns and other sources have different health impacts could inform health and environmental interventions around the world. Luby leads a collaboration among public health experts, industry stakeholders, technology consultants and government agencies to improve the industry. He received funding for related work focused on brick kilns and other industries, funded by the Sustainability Initiative that gave rise to Stanford?s new school focused on climate and sustainability.
?We?re still only looking at a small slice of the potential health outcomes that might be linked to this kind of air pollution, and we still lack perfect measurements of exposure to it,? said Sherris. ?The true health burden is likely much greater.
";s:14:"date_timestamp";i:1634745295;}i:5;a:11:{s:5:"title";s:124:"The White House unveils its vaccination plan against covid-19 for children from 5 to 11 years old | Univision Politics News";s:4:"link";s:147:"https://travors.com/news/the-white-house-unveils-its-vaccination-plan-against-covid-19-for-children-from-5-to-11-years-old-univision-politics-news/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 15:24:51 +0000";s:8:"category";s:4:"News";s:4:"guid";s:147:"https://travors.com/news/the-white-house-unveils-its-vaccination-plan-against-covid-19-for-children-from-5-to-11-years-old-univision-politics-news/";s:11:"description";s:820:"The White House announced this Wednesday its vaccination plan against the coronavirus to children from 5 to 11 years old while awaiting approval from the Food and Drug Administration (FDA), whose decision is scheduled for sometime next week. The government of the president Joe Biden indicated that there are enough doses of the Pfizer / ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4735:"
The White House announced this Wednesday its vaccination plan against the coronavirus to children from 5 to 11 years old while awaiting approval from the Food and Drug Administration (FDA), whose decision is scheduled for sometime next week.
The government of the president Joe Biden indicated that there are enough doses of the Pfizer / BioNTech vaccine to 28 million children belonging to that age group.
?Today, the Biden Administration announces a plan to ensure that, if a vaccine is licensed for children ages 5 to 11, it is distributed quickly and is conveniently and equitably available to families across the country?Said the White House in a statement.
The FDA’s expert advisory group is expected to meet Oct. 26 to hear data on the safety and efficacy of the Pfizer-BioNTech pediatric vaccine.
For its part, a vaccine advisory panel from the Centers for Disease Control and Prevention (CDC) meets on November 2 and 3 to evaluate a recommendation for use. If the CDC director approves a recommendation for use, the vaccine can be given to children.
As indicated by the White House, the Department of Health and Human Services also conduct a national public education campaign in order to “reach parents and guardians with accurate and culturally sensitive information about the vaccine and the risks that covid-19 poses to children.”
FDA vaccine advisers are scheduled to meet next week to consider Pfizer’s application to license that vaccine.
If he finally gives the go-ahead, this would be the first covid-19 vaccine for the smallest in the country. The Pfizer / BioNTech vaccine is currently approved for individuals 16 years of age and older and has emergency authorization for children 12-15 years of age.
The vaccine in children will be distributed quickly
The White House has promised that, once authorized, quickly distribute vaccines throughout the country, with more than 25,000 pediatric offices and primary care centers, as well as hospitals. White House officials said they are conducting “operational readiness calls” with local jurisdictions.
The White House says in the statement that, as with vaccination for those over 12 years of age, “the success of this program will depend largely on the states, tribes and territories to help implement a smooth implementation.”
Millions of adolescents between 12 and 17 years have been safely vaccinated so far. “We know that vaccines work. Fully vaccinated people are 10 times less likely to be hospitalized with COVID-19 and have a high degree of protection, even against the Delta variant,” the statement added.
The White House recalled that the consequences of a case of covid-19 pediatric conditions can be serious and potentially last for months.
";}s:7:"summary";s:820:"The White House announced this Wednesday its vaccination plan against the coronavirus to children from 5 to 11 years old while awaiting approval from the Food and Drug Administration (FDA), whose decision is scheduled for sometime next week. The government of the president Joe Biden indicated that there are enough doses of the Pfizer / ... Read more";s:12:"atom_content";s:4735:"
The White House announced this Wednesday its vaccination plan against the coronavirus to children from 5 to 11 years old while awaiting approval from the Food and Drug Administration (FDA), whose decision is scheduled for sometime next week.
The government of the president Joe Biden indicated that there are enough doses of the Pfizer / BioNTech vaccine to 28 million children belonging to that age group.
?Today, the Biden Administration announces a plan to ensure that, if a vaccine is licensed for children ages 5 to 11, it is distributed quickly and is conveniently and equitably available to families across the country?Said the White House in a statement.
The FDA’s expert advisory group is expected to meet Oct. 26 to hear data on the safety and efficacy of the Pfizer-BioNTech pediatric vaccine.
For its part, a vaccine advisory panel from the Centers for Disease Control and Prevention (CDC) meets on November 2 and 3 to evaluate a recommendation for use. If the CDC director approves a recommendation for use, the vaccine can be given to children.
As indicated by the White House, the Department of Health and Human Services also conduct a national public education campaign in order to “reach parents and guardians with accurate and culturally sensitive information about the vaccine and the risks that covid-19 poses to children.”
FDA vaccine advisers are scheduled to meet next week to consider Pfizer’s application to license that vaccine.
If he finally gives the go-ahead, this would be the first covid-19 vaccine for the smallest in the country. The Pfizer / BioNTech vaccine is currently approved for individuals 16 years of age and older and has emergency authorization for children 12-15 years of age.
The vaccine in children will be distributed quickly
The White House has promised that, once authorized, quickly distribute vaccines throughout the country, with more than 25,000 pediatric offices and primary care centers, as well as hospitals. White House officials said they are conducting “operational readiness calls” with local jurisdictions.
The White House says in the statement that, as with vaccination for those over 12 years of age, “the success of this program will depend largely on the states, tribes and territories to help implement a smooth implementation.”
Millions of adolescents between 12 and 17 years have been safely vaccinated so far. “We know that vaccines work. Fully vaccinated people are 10 times less likely to be hospitalized with COVID-19 and have a high degree of protection, even against the Delta variant,” the statement added.
The White House recalled that the consequences of a case of covid-19 pediatric conditions can be serious and potentially last for months.
";s:14:"date_timestamp";i:1634743491;}i:6;a:11:{s:5:"title";s:97:"Researchers develop proof-of-concept treatment that elevates adult and fetal hemoglobin ? NovLink";s:4:"link";s:136:"https://travors.com/health-science-news/researchers-develop-proof-of-concept-treatment-that-elevates-adult-and-fetal-hemoglobin-novlink/";s:2:"dc";a:1:{s:7:"creator";s:14:"stephen Henbie";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 14:53:53 +0000";s:8:"category";s:21:"Health & Science News";s:4:"guid";s:136:"https://travors.com/health-science-news/researchers-develop-proof-of-concept-treatment-that-elevates-adult-and-fetal-hemoglobin-novlink/";s:11:"description";s:838:"Journal Reference: Silvia Pires Lourenco, Danuta Jarocha, Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella. Inclusion of a shRNA targeting BCL11A into a ?-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica, 2021; DOI: ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5165:"
Journal Reference:
Silvia Pires Lourenco, Danuta Jarocha, Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella. Inclusion of a shRNA targeting BCL11A into a ?-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica, 2021; DOI: 10.3324/haematol.2020.276634
?Until now, researchers have been exploring one of two approaches to treating blood disorders like sickle cell disease or beta-thalassemia: adding a functional copy of the adult hemoglobin gene, or increasing production of fetal hemoglobin,? said senior author Stefano Rivella, PhD, Kwame Ohene-Frempong Chair on Sickle Cell Anemia and Professor of Pediatrics at CHOP. ?In this study, we have done both simultaneously, which provides an opportunity to produce more hemoglobin per vector in these patients.?
Sickle cell disease and beta-thalassemia are genetic blood disorders caused by errors in the genes for hemoglobin, a protein that is found in red blood cells and carries oxygen from the lungs to tissues throughout the body. In utero, the gamma-globin gene produces fetal hemoglobin, but after birth, this gene is switched off and the beta-globin gene is turned on, producing adult hemoglobin. Patients with sickle cell disease and beta-thalassemia have mutations in the beta-globin gene, which leads to mutant hemoglobin production and, as a consequence, serious health complications, ranging from delayed growth and jaundice to pain crises, pulmonary hypertension, and stroke.
Current research has focused on treating these blood disorders by either increasing fetal hemoglobin, which is not mutated in these conditions, or adding back a functional copy of adult hemoglobin via gene therapy, using an engineered vehicle known as a viral vector to supply new genetic material. However, there are limitations to both of these approaches, and neither has been established as a fully curative approach.
In order to increase hemoglobin levels in one therapy, the researchers ? led by co-first authors Danuta Jarocha, PhD and Silvia Lourenco, PhD ? combined the two tactics into a single gene therapy vector. To do so, they focused on a transcription factor called BCL11A, which effectively operates the switch that turns off the production of fetal hemoglobin and turns on the production of adult hemoglobin. The researchers hypothesized that if they could use an engineered vector to repress BCL11A, which would keep fetal hemoglobin production turned on and turn off the production of mutant adult hemoglobin, while also adding back a functional copy of the beta-globin gene, they could induce greater hemoglobin production.
Working in cell lines of patients with sickle cell disease and beta-thalassemia, the researchers tested their vector ? which included a gene coding for adult hemoglobin and a microRNA sequence that would target BCL11A ? and found that the vector was able to elevate fetal and adult hemoglobin simultaneously in vitro. Although BCL11A was not completely knocked down, the suppression was sufficient to reduce production of the mutant adult hemoglobin. By elevating both fetal and functional adult hemoglobin, the vector was able to induce more functional hemoglobin production than that of a vector expressing beta-globin alone.
?Future studies will evaluate this approach using an even stronger vector that we developed in our lab and published on recently,? Rivella said. ?Combining these two technologies, we hope to make an even more powerful vector that can provide curative levels of hemoglobin to these patients.?
This research was supported by the CuRED Frontier Program at CHOP, which is dedicated to finding new and improved curative therapies for blood disorders like sickle cell disease and beta-thalassemia.
";}s:7:"summary";s:838:"Journal Reference: Silvia Pires Lourenco, Danuta Jarocha, Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella. Inclusion of a shRNA targeting BCL11A into a ?-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica, 2021; DOI: ... Read more";s:12:"atom_content";s:5165:"
Journal Reference:
Silvia Pires Lourenco, Danuta Jarocha, Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella. Inclusion of a shRNA targeting BCL11A into a ?-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica, 2021; DOI: 10.3324/haematol.2020.276634
?Until now, researchers have been exploring one of two approaches to treating blood disorders like sickle cell disease or beta-thalassemia: adding a functional copy of the adult hemoglobin gene, or increasing production of fetal hemoglobin,? said senior author Stefano Rivella, PhD, Kwame Ohene-Frempong Chair on Sickle Cell Anemia and Professor of Pediatrics at CHOP. ?In this study, we have done both simultaneously, which provides an opportunity to produce more hemoglobin per vector in these patients.?
Sickle cell disease and beta-thalassemia are genetic blood disorders caused by errors in the genes for hemoglobin, a protein that is found in red blood cells and carries oxygen from the lungs to tissues throughout the body. In utero, the gamma-globin gene produces fetal hemoglobin, but after birth, this gene is switched off and the beta-globin gene is turned on, producing adult hemoglobin. Patients with sickle cell disease and beta-thalassemia have mutations in the beta-globin gene, which leads to mutant hemoglobin production and, as a consequence, serious health complications, ranging from delayed growth and jaundice to pain crises, pulmonary hypertension, and stroke.
Current research has focused on treating these blood disorders by either increasing fetal hemoglobin, which is not mutated in these conditions, or adding back a functional copy of adult hemoglobin via gene therapy, using an engineered vehicle known as a viral vector to supply new genetic material. However, there are limitations to both of these approaches, and neither has been established as a fully curative approach.
In order to increase hemoglobin levels in one therapy, the researchers ? led by co-first authors Danuta Jarocha, PhD and Silvia Lourenco, PhD ? combined the two tactics into a single gene therapy vector. To do so, they focused on a transcription factor called BCL11A, which effectively operates the switch that turns off the production of fetal hemoglobin and turns on the production of adult hemoglobin. The researchers hypothesized that if they could use an engineered vector to repress BCL11A, which would keep fetal hemoglobin production turned on and turn off the production of mutant adult hemoglobin, while also adding back a functional copy of the beta-globin gene, they could induce greater hemoglobin production.
Working in cell lines of patients with sickle cell disease and beta-thalassemia, the researchers tested their vector ? which included a gene coding for adult hemoglobin and a microRNA sequence that would target BCL11A ? and found that the vector was able to elevate fetal and adult hemoglobin simultaneously in vitro. Although BCL11A was not completely knocked down, the suppression was sufficient to reduce production of the mutant adult hemoglobin. By elevating both fetal and functional adult hemoglobin, the vector was able to induce more functional hemoglobin production than that of a vector expressing beta-globin alone.
?Future studies will evaluate this approach using an even stronger vector that we developed in our lab and published on recently,? Rivella said. ?Combining these two technologies, we hope to make an even more powerful vector that can provide curative levels of hemoglobin to these patients.?
This research was supported by the CuRED Frontier Program at CHOP, which is dedicated to finding new and improved curative therapies for blood disorders like sickle cell disease and beta-thalassemia.
";s:14:"date_timestamp";i:1634741633;}i:7;a:11:{s:5:"title";s:55:"Extradition to the US of Hugo Carvajal Barrios approved";s:4:"link";s:81:"https://travors.com/news/extradition-to-the-us-of-hugo-carvajal-barrios-approved/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 14:41:43 +0000";s:8:"category";s:4:"News";s:4:"guid";s:81:"https://travors.com/news/extradition-to-the-us-of-hugo-carvajal-barrios-approved/";s:11:"description";s:670:"Hugo “Pollo” Carvajal, former head of intelligence of Venezuela. (CNN) — Spain’s high court approved the extradition of former Venezuelan intelligence director Hugo Armando Carvajal Barrios, also known as “El Pollo,” to the United States, a court spokesman told CNN on Wednesday. Carvajal was arrested in Madrid last month for his alleged involvement in large-scale ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7144:"
Hugo “Pollo” Carvajal, former head of intelligence of Venezuela.
(CNN) — Spain’s high court approved the extradition of former Venezuelan intelligence director Hugo Armando Carvajal Barrios, also known as “El Pollo,” to the United States, a court spokesman told CNN on Wednesday.
Carvajal was arrested in Madrid last month for his alleged involvement in large-scale drug trafficking activities, the United States Department of Justice said at the time.
He was indicted last year in the Southern District of New York for allegedly participating in a narco-terrorism conspiracy and a conspiracy to import cocaine into the United States, including a 5.6-ton shipment of cocaine transported from Venezuela to Mexico in April 2006. He also faces crimes related to firearms.
Arrest of Hugo Carvajal in Madrid
Carvajal was Hugo Chávez’s trusted man and one of his closest collaborators.
His link with the late leader of Venezuela dates back to 1992, the year in which both participated in an attempted coup against then-President Carlos Andrés Pérez and ended up in prison.
";}s:7:"summary";s:670:"Hugo “Pollo” Carvajal, former head of intelligence of Venezuela. (CNN) — Spain’s high court approved the extradition of former Venezuelan intelligence director Hugo Armando Carvajal Barrios, also known as “El Pollo,” to the United States, a court spokesman told CNN on Wednesday. Carvajal was arrested in Madrid last month for his alleged involvement in large-scale ... Read more";s:12:"atom_content";s:7144:"
Hugo “Pollo” Carvajal, former head of intelligence of Venezuela.
(CNN) — Spain’s high court approved the extradition of former Venezuelan intelligence director Hugo Armando Carvajal Barrios, also known as “El Pollo,” to the United States, a court spokesman told CNN on Wednesday.
Carvajal was arrested in Madrid last month for his alleged involvement in large-scale drug trafficking activities, the United States Department of Justice said at the time.
He was indicted last year in the Southern District of New York for allegedly participating in a narco-terrorism conspiracy and a conspiracy to import cocaine into the United States, including a 5.6-ton shipment of cocaine transported from Venezuela to Mexico in April 2006. He also faces crimes related to firearms.
Arrest of Hugo Carvajal in Madrid
Carvajal was Hugo Chávez’s trusted man and one of his closest collaborators.
His link with the late leader of Venezuela dates back to 1992, the year in which both participated in an attempted coup against then-President Carlos Andrés Pérez and ended up in prison.
";s:14:"date_timestamp";i:1634740903;}i:8;a:11:{s:5:"title";s:66:"The morning news, Wednesday, October 20, 2021 ? Noticias Telemundo";s:4:"link";s:87:"https://travors.com/news/the-morning-news-wednesday-october-20-2021-noticias-telemundo/";s:2:"dc";a:1:{s:7:"creator";s:24:"First Name 1 Last Name 1";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 13:58:49 +0000";s:8:"category";s:4:"News";s:4:"guid";s:87:"https://travors.com/news/the-morning-news-wednesday-october-20-2021-noticias-telemundo/";s:11:"description";s:727:"The morning news, wednesday, october 20, 2021 Telemundo News Goodbye to Facebook: Mark Zuckerberg plans to change the name of the social network The confidential Facebook plans to change its name, according to a report CNN Facebook prepares its own Alphabet: it will change its name because the metaverse already matters more than the networks … Engadget Facebook will ... Read more";s:7:"content";a:1:{s:7:"encoded";s:1777:"
";}s:7:"summary";s:727:"The morning news, wednesday, october 20, 2021 Telemundo News Goodbye to Facebook: Mark Zuckerberg plans to change the name of the social network The confidential Facebook plans to change its name, according to a report CNN Facebook prepares its own Alphabet: it will change its name because the metaverse already matters more than the networks … Engadget Facebook will ... Read more";s:12:"atom_content";s:1777:"
";s:14:"date_timestamp";i:1634738329;}i:9;a:11:{s:5:"title";s:114:"Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands ? NovLink";s:4:"link";s:153:"https://travors.com/health-science-news/lake-formation-and-expansion-due-to-sea-level-rise-causes-freshwater-resource-depletion-on-small-islands-novlink/";s:2:"dc";a:1:{s:7:"creator";s:14:"stephen Henbie";}s:7:"pubdate";s:31:"Wed, 20 Oct 2021 13:52:50 +0000";s:8:"category";s:21:"Health & Science News";s:4:"guid";s:153:"https://travors.com/health-science-news/lake-formation-and-expansion-due-to-sea-level-rise-causes-freshwater-resource-depletion-on-small-islands-novlink/";s:11:"description";s:336:"Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands ? NovLink Home Mash Q Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands";s:7:"content";a:1:{s:7:"encoded";s:7452:"
Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands ? NovLink
";}s:7:"summary";s:336:"Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands ? NovLink Home Mash Q Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands";s:12:"atom_content";s:7452:"
Lake formation and expansion due to sea-level rise causes freshwater resource depletion on small islands ? NovLink
